Gipr - gastric inhibitory polypeptide receptor Gene

Also Known as GIP-R; Gm160; Gm1081

Species: Mus musculus

Gene Type: protein coding
Gene ID: 381853

Summary

Predicted to enable G protein-coupled peptide receptor activity; gastric inhibitory peptide receptor activity; and glucagon family peptide binding activity. Acts upstream of or within endocrine pancreas development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in foregut-midgut junction; pancreas; and pancreas primordium. Human ortholog(s) of this gene implicated in cardiovascular system disease; diabetes mellitus; obesity; and type 2 diabetes mellitus. Orthologous to human GIPR (gastric inhibitory polypeptide receptor). [provided by Alliance of Genome Resources, Apr 2022]

Gipr Products (1)

mRNA Protein Name
NM_001080815.1 NP_001074284.1 gastric inhibitory polypeptide receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables gastric inhibitory peptide receptor activity IDA
IDA: Inferred from direct assay
17971513 MGI
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
15111503 MGI
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
23099862 MGI
acts upstream of or within endocrine pancreas development IMP
IMP: Inferred from mutant phenotype
21270265 MGI
involved in positive regulation of insulin secretion IGI
IGI: Inferred from genetic interaction
15111503 MGI
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
23099862 MGI
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
17971513 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gastric inhibitory polypeptide receptor

  • glucose-dependent insulinotropic polypeptide receptor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-P11672 Poterepatide Agonist 99.78% Phase 3
HY-P3506B Retatrutide acetate Agonist 99.69% Phase 3
HY-164535 Maridebart cafraglutide 99.24% Phase 1
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990047 Maridebart Inhibitor 99.90% Phase 3

Pre-clinical Phase

Bioactive Molecules (28)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3506 Retatrutide Agonist 99.96% Unkown
HY-P10735 GIP (mouse) 98.79% Unkown
HY-P3506A Retatrutide TFA Agonist 99.47% Unkown
HY-P10736A AMG133 peptide payload TFA Agonist 99.70% Unkown
HY-P10736 AMG133 peptide payload 99.94% Unkown
HY-P10302A GLP-1R/GIPR agonist-1 (soduim) Agonist 98.24% Unkown
HY-P10271 RG7697 Agonist 99.90% Unkown
HY-P11321A IUB0271 hydrochloride 98.67% Unkown
HY-P3584A (Pro3) GIP, human TFA 99.89% Unkown
HY-P10031 SAR441255 Agonist 99.84% Unkown
HY-P10031A SAR441255 TFA Agonist 99.93% Unkown
HY-186050 GIPR antagonist 2 Agonist 99.48% Unkown
HY-P10302 GLP-1R/GIPR agonist-1 Agonist / Unkown
HY-P3584 (Pro3) GIP, human Agonist 99.79% Unkown
HY-171302 GLP-1R/GIPR agonist-2 Agonist / Unkown
HY-173479 GLP-1R agonist 30 Agonist / Unkown
HY-179332 GIPR antagonist 1 / Unkown
HY-181709 TPM003 Agonist / Unkown
HY-182580 HBK001 / Unkown
HY-P11275 TC4 Agonist / Unkown
HY-P11279 TC2 Agonist / Unkown
HY-P11321 IUB0271 / Unkown
HY-P11487 UTG-4 Agonist / Unkown
HY-P11818 GIPR/GLP-1R/GCGR agonist-1 / Unkown
HY-P11880 LY3324954 Agonist / Unkown
HY-RS05437 GIPR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17884 Gipr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24353 Gipr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gipr NCBI NCBI:2696