Si - sucrase-isomaltase Gene

Also Known as SUCIMAL

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 497756

Summary

Enables beta-fructofuranosidase activity and oligo-1,6-glucosidase activity. Involved in several processes, including response to fructose; response to sucrose; and response to vitamin A. Located in brush border and membrane raft. Biomarker of colitis. Human ortholog(s) of this gene implicated in congenital sucrase-isomaltase deficiency. Orthologous to human SI (sucrase-isomaltase). [provided by Alliance of Genome Resources, Apr 2022]

Si Products (1)

mRNA Protein Name
NM_001389226.1 NP_001376155.1 sucrase-isomaltase, intestinal

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-fructofuranosidase activity IDA
IDA: Inferred from direct assay
6802834 RGD
enables oligo-1,6-glucosidase activity IDA
IDA: Inferred from direct assay
6802834 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15138292 RGD
Biological Process GO Annotation Evidence References Source
involved in response to fructose IEP
IEP: Inferred from expression pattern
15539244 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
9618286 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
9585003 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
7873573 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
10864000 RGD
involved in response to sucrose IEP
IEP: Inferred from expression pattern
8890076 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
15309444 RGD
Cellular Component GO Annotation Evidence References Source
located in brush border IDA
IDA: Inferred from direct assay
15138292 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sucrase-isomaltase, intestinal

  • sucrase-isomaltase (alpha-glucosidase)

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99676 Izalontamab Inhibitor 99.89% Phase 3

Pre-clinical Phase

Bioactive Molecules (87)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139426 ML-SI3 Inhibitor 99.91% Unkown
HY-129602 SD-36 99.73% Unkown
HY-134818 ML-SI1 Inhibitor 99.80% Unkown
HY-D0175 3-Aminopropyltriethoxysilane 99.83% Unkown
HY-126247 BI-2852 Inhibitor 99.46% Unkown
HY-134819A (1R,2R)-ML-SI3 Inhibitor 99.79% Unkown
HY-129603 SI-109 Inhibitor 99.91% Unkown
HY-101447A SI-2 hydrochloride Inhibitor 98.06% Unkown
HY-139426A (rel)-ML-SI3 98.94% Unkown
HY-117357 SI-113 Inhibitor 98.09% Unkown
HY-130812 Gemcitabine-O-Si(di-iso)-O-Mc 98.82% Unkown
HY-134819 (1S,2S)-ML-SI3 Inhibitor 99.96% Unkown
HY-121537 CAY10404 99.40% Unkown
HY-126247B (R)-BI-2852 Control 97.32% Unkown
HY-130818 N-(5-Hydroxypentyl)maleimide 99.49% Unkown
HY-163469 SRC-3-IN-2 Inhibitor 96.32% Unkown
HY-137498 EBOV/MARV-IN-1 Inhibitor 99.14% Unkown
HY-174066 SI-W052 98.0% Unkown
HY-175703 RANKL-IN-1 Inhibitor / Unkown
HY-178970 HDAC11-IN-4 Inhibitor 95.0% Unkown
HY-150927 G12Si-2 Inhibitor / Unkown
HY-101447 SI-2 / Unkown
HY-115929 DENV-IN-4 Inhibitor / Unkown
HY-115989 HCV-IN-38 Inhibitor / Unkown
HY-119396 DY3002 / Unkown
HY-121582 (E)-SI-2 / Unkown
HY-131559 N-Deacetyl-SI-109-(OEt)2 / Unkown
HY-131721 14,15-EET-SI Activator / Unkown
HY-133135 CHIKV-IN-1 Inhibitor / Unkown
HY-139845 Antiviral agent 9 Inhibitor / Unkown
HY-144749 AKR1C3-IN-5 / Unkown
HY-145432 PI3K-IN-28 Inhibitor / Unkown
HY-146815 CP19 / Unkown
HY-150554 Antitubercular agent-29 Inhibitor / Unkown
HY-150895 SI-191 Ligand / Unkown
HY-151174 PDE4-IN-12 Inhibitor / Unkown
HY-151612 Anti-infective agent 6 Inhibitor / Unkown
HY-153162A (-)-IHCH7041 Agonist / Unkown
HY-162833 Antileishmanial agent-30 Inhibitor / Unkown
HY-163468 SRC-3-IN-1 Inhibitor / Unkown
HY-168301 CL-13 Inhibitor / Unkown
HY-169968 E3 ligase Ligand 41 / Unkown
HY-170958 Scr-IN-1 / Unkown
HY-173368 Antiproliferative agent-67 Inhibitor / Unkown
HY-175518 PADI4-IN-1 Inhibitor / Unkown
HY-175531 EGFR-IN-169 / Unkown
HY-175703A RANKL-IN-1 formate Inhibitor 99.74% Unkown
HY-176285S Silicon-29, metal particles / Unkown
HY-176285S1 Silicon-30, metal particles / Unkown
HY-176286S Silica-29Si / Unkown
HY-176286S1 Silica-30Si / Unkown
HY-178141 AChE/BuChE-IN-7 Inhibitor / Unkown
HY-178454 Multitarget AD-IN-3 Inhibitor / Unkown
HY-179251 BDGR-651 Inhibitor / Unkown
HY-179348 DPP9-IN-2 / Unkown
HY-179363 BChE-IN-46 Inhibitor / Unkown
HY-179723 GSK3β-IN-4 Inhibitor / Unkown
HY-180142 XYDC2050 Antagonist / Unkown
HY-180171 USP11-IN-1 Inhibitor / Unkown
HY-184381 MAO-B-IN-61 Inhibitor / Unkown
HY-B0389S20 D-Glucose-13C,d-1 99.7% Unkown
HY-B0389S22 D-Glucose-13C2,d2 / Unkown
HY-D3360 JF630-HTL Chemical / Unkown
HY-D3409 Si-DMA / Unkown
HY-E71514 2-Dehydropantolactone reductase / Unkown
HY-E71514B 2-Dehydropantolactone reductase (Si-specific) / Unkown
HY-E71717B 3α-Hydroxysteroid 3-dehydrogenase (Si-specific) / Unkown
HY-RS10760 PMEL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12889 SI Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W026467 MMV665916 Inhibitor / Unkown
HY-121914 (2-Chlorophenyl)diphenylmethanol Inhibitor 99.92% Unkown
HY-159915 Se2h Inhibitor / Unkown
HY-164527 Si306 Inhibitor / Unkown
HY-165603 Si5-N14 Inhibitor / Unkown
HY-169920 HIV-1 inhibitor-79 Inhibitor / Unkown
HY-170922 SARS-CoV-2-IN-110 Inhibitor / Unkown
HY-170940 Dyrk1A-IN-12 Inhibitor / Unkown
HY-174782 Human ACVR2B mRNA / Unkown
HY-175016 NADH-IN-3 Inhibitor / Unkown
HY-175724 MBL-IN-6 Inhibitor / Unkown
HY-178994 DENV-IN-14 Inhibitor / Unkown
HY-179710 SET-12 / Unkown
HY-180217 WGU55 Inhibitor / Unkown
HY-180673 Mpro/RdRp-IN-1 Inhibitor / Unkown
HY-RS18892 Ebp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23315 Si Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24785 Eef1a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Si NCBI NCBI:6476