2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC11-IN-4

HDAC11-IN-4 is a potent and selective HDAC11 inhibitor with an IC50 of 13.49 nM and a Ki of 2.2 nM. HDAC11-IN-4 exhibits extremely high selectivity for HDAC11 over other defatty-acylases such as SIRT2, SIRT3, SIRT6, and HDAC8 (SI >10,000). HDAC11-IN-4 can be used for the research of cancer.

For research use only. We do not sell to patients.

HDAC11-IN-4

HDAC11-IN-4 Chemical Structure

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Based on 1 publication(s) in Google Scholar

HDAC11-IN-4 Related Antibodies

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View All HDAC Isoform Specific Products:

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC11-IN-4 is a potent and selective HDAC11 inhibitor with an IC50 of 13.49 nM and a Ki of 2.2 nM. HDAC11-IN-4 exhibits extremely high selectivity for HDAC11 over other defatty-acylases such as SIRT2, SIRT3, SIRT6, and HDAC8 (SI >10,000). HDAC11-IN-4 can be used for the research of cancer[1].

IC50 & Target[1]

HDAC11

13.49 nM (IC50)

HDAC11

2.2 nM (Ki)

Molecular Weight

527.76

Formula

C26H49N5O4S
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCSC[C@H](C(NCCCC[C@@H]1NC([C@@H](NC1=O)CCC(N)=O)=O)=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (189.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8948 mL 9.4740 mL 18.9480 mL
5 mM 0.3790 mL 1.8948 mL 3.7896 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8948 mL 9.4740 mL 18.9480 mL 47.3700 mL
5 mM 0.3790 mL 1.8948 mL 3.7896 mL 9.4740 mL
10 mM 0.1895 mL 0.9474 mL 1.8948 mL 4.7370 mL
15 mM 0.1263 mL 0.6316 mL 1.2632 mL 3.1580 mL
20 mM 0.0947 mL 0.4737 mL 0.9474 mL 2.3685 mL
25 mM 0.0758 mL 0.3790 mL 0.7579 mL 1.8948 mL
30 mM 0.0632 mL 0.3158 mL 0.6316 mL 1.5790 mL
40 mM 0.0474 mL 0.2369 mL 0.4737 mL 1.1843 mL
50 mM 0.0379 mL 0.1895 mL 0.3790 mL 0.9474 mL
60 mM 0.0316 mL 0.1579 mL 0.3158 mL 0.7895 mL
80 mM 0.0237 mL 0.1184 mL 0.2369 mL 0.5921 mL
100 mM 0.0189 mL 0.0947 mL 0.1895 mL 0.4737 mL
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HDAC11-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC11-IN-4HDACHistone deacetylasesHDAC11SIRT2SIRT3SIRT6and HDAC8cancerInhibitorinhibitorinhibit

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