Cdk8 - cyclin-dependent kinase 8 Gene

Also Known as RGD1560888

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 498140

About Cdk8

Primary_assembly 12: 8,737,262-8,804,177 reverse strand.mRatBN7.2:CM026985.1

This gene has 2 transcripts (splice variants), 217 orthologues and 24 paralogues. Biased expression in Lung (RPKM 121.4), Kidney (RPKM 18.9) and 9 other tissues.

Summary

Contributes to ubiquitin protein Ligase activity. Involved in negative regulation of triglyceride metabolic process and protein ubiquitination. Part of ubiquitin Ligase complex. Orthologous to human CDK8 (cyclin dependent kinase 8). [provided by Alliance of Genome Resources, Apr 2022]

Cdk8 Products (1)

mRNA Protein Name
NM_001109061.1 NP_001102531.1 cyclin-dependent kinase 8

Cdk8 Protein Structure

STKc_CDK8

STKc_CDK8: cd07868 (2 - 334)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 464 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 8

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-X0009 Tambiciclib Inhibitor 99.68% Phase 2
HY-137478 KB-0742 Inhibitor 99.63% Phase 2
HY-101800 Senexin B Inhibitor 99.09% Phase 1
HY-111388B Romaciclib hydrochloride Inhibitor 99.98% Phase 1

Pre-clinical Phase

Bioactive Molecules (53)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0400 Wogonin Inhibitor 99.83% Unkown
HY-120350 BI-1347 Inhibitor 99.85% Unkown
HY-126675A AS2863619 Inhibitor 98.02% Unkown
HY-111388A Romaciclib monohydrochloride Inhibitor 99.29% Unkown
HY-15681 Senexin A Inhibitor 99.58% Unkown
HY-101611 MSC2530818 Inhibitor 99.62% Unkown
HY-137478A KB-0742 dihydrochloride Inhibitor 98.77% Unkown
HY-19984 CCT-251921 Inhibitor 99.12% Unkown
HY-122586 BRD6989 Inhibitor 99.54% Unkown
HY-145121 DS96432529 Inhibitor 99.93% Unkown
HY-12280 THZ2 Inhibitor 99.03% Unkown
HY-156366 SNX7886 Degrader 99.71% Unkown
HY-126675 AS2863619 free base Inhibitor 99.87% Unkown
HY-111518 JH-XI-10-02 Inhibitor 99.65% Unkown
HY-149209 LL-K8-22 Degrader 99.06% Unkown
HY-139875 JH-XVI-178 Inhibitor 98.87% Unkown
HY-12293 LY2857785 Inhibitor 99.21% Unkown
HY-143889 Senexin C Inhibitor 99.19% Unkown
HY-149974 CDK8-IN-13 Inhibitor 99.14% Unkown
HY-168683 CDK8 ligand 1 Degrader 99.88% Unkown
HY-151463 CDK8-IN-11 Inhibitor 98.18% Unkown
HY-111388 SEL120-34A Inhibitor 99.49% Unkown
HY-178861 dCDK9-202 Modulator 99.25% Unkown
HY-111427 CDK8/19-IN-1 Inhibitor 98.08% Unkown
HY-X0009A Tambiciclib dimaleate Inhibitor 99.55% Unkown
HY-170813 P162-0948 Inhibitor 99.39% Unkown
HY-103492 CDK8-IN-1 Inhibitor 98.62% Unkown
HY-148561 CDK8-IN-12 Inhibitor 99.74% Unkown
HY-125001 JH-VIII-49 Inhibitor / Unkown
HY-15681A Senexin A hydrochloride Inhibitor / Unkown
HY-168846 CDK8/19-IN-3 Inhibitor / Unkown
HY-182986 LS-Q2 Inhibitor / Unkown
HY-147716 CDK8-IN-6 Inhibitor / Unkown
HY-137478B KB-0742 hydrochloride Inhibitor / Unkown
HY-114178 CDK8-IN-2 Inhibitor / Unkown
HY-176281 PI3Kα-IN-26 Inhibitor / Unkown
HY-158377 CDK8/19-IN-2 Inhibitor / Unkown
HY-169541 CDK8-IN-18 Inhibitor / Unkown
HY-184727 CDK8/BRD4-IN-1 Inhibitor / Unkown
HY-169633 CDK8-IN-17 Inhibitor / Unkown
HY-176282 CDK8-IN-19 Inhibitor / Unkown
HY-162600 CDK8-IN-15 Inhibitor / Unkown
HY-187035 SNX631 Inhibitor / Unkown
HY-183074 RO8323 Inhibitor / Unkown
HY-180124 CDK8-IN-20 Inhibitor / Unkown
HY-187688 SW393109 Inhibitor / Unkown
HY-N0400R Wogonin (Standard) Inhibitor 98.70% Unkown
HY-147527 CDK8-IN-5 Inhibitor / Unkown
HY-147717 CDK8-IN-7 Inhibitor / Unkown
HY-151371 CDK8-IN-10 Inhibitor / Unkown
HY-184544 CDK8 ligand 2 / Unkown
HY-171174 CDK8-IN-16 Inhibitor / Unkown
HY-183423 MK256 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk8 NCBI NCBI:1024