2. Gene
  3. Cdk8 - cyclin-dependent kinase 8 Gene

Cdk8 - cyclin-dependent kinase 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1560888

Gene ID: 498140 | Gene type: protein coding

About Cdk8

Primary_assembly 12: 8,737,262-8,804,177 reverse strand.mRatBN7.2:CM026985.1

This gene has 2 transcripts (splice variants), 217 orthologues and 24 paralogues. Biased expression in Lung (RPKM 121.4), Kidney (RPKM 18.9) and 9 other tissues.

Summary

Contributes to ubiquitin protein ligase activity. Involved in negative regulation of triglyceride metabolic process and protein ubiquitination. Part of ubiquitin ligase complex. Orthologous to human CDK8 (cyclin dependent kinase 8). [provided by Alliance of Genome Resources, Apr 2022]

Cdk8 Products(1)

mRNA Protein Name
NM_001109061.1 NP_001102531.1 cyclin-dependent kinase 8

Cdk8 Protein Structure

STKc_CDK8

STKc_CDK8: cd07868 (2 - 334)

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  • 464 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 8

Related Agents

Pre-clinical Phase
Bioactive Molecules (30)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0400 Wogonin Inhibitor 99.92% Unkown
HY-120350 BI-1347 Inhibitor 98.95% Unkown
HY-126675A AS2863619 Inhibitor 99.94% Unkown
HY-111388A SEL120-34A monohydrochloride Inhibitor 98.69% Unkown
HY-101611 MSC2530818 Inhibitor 99.67% Unkown
HY-19984 CCT-251921 Inhibitor 98.86% Unkown
HY-15681 Senexin A Inhibitor 99.85% Unkown
HY-111518 JH-XI-10-02 Inhibitor 99.82% Unkown
HY-12293 LY2857785 Inhibitor 99.92% Unkown
HY-122586 BRD6989 Inhibitor 99.56% Unkown
HY-12280 THZ2 Inhibitor 99.03% Unkown
HY-145121 DS96432529 Inhibitor 99.79% Unkown
HY-111388B SEL120-34A hydrochloride Inhibitor 99.98% Unkown
HY-126675 AS2863619 free base Inhibitor 99.87% Unkown
HY-139875 JH-XVI-178 Inhibitor 98.16% Unkown
HY-103492 CDK8-IN-1 Inhibitor 99.77% Unkown
HY-101800 Senexin B Inhibitor 99.72% Unkown
HY-143889 Senexin C Inhibitor 98.06% Unkown
HY-111427 CDK8/19-IN-1 Inhibitor 98.03% Unkown
HY-149974 CDK8-IN-13 Inhibitor 99.14% Unkown
HY-149209 LL-K8-22 Degrader 99.76% Unkown
HY-151463 CDK8-IN-11 Inhibitor 98.20% Unkown
HY-111388 SEL120-34A Inhibitor / Unkown
HY-15681A Senexin A hydrochloride Inhibitor / Unkown
HY-147716 CDK8-IN-6 Inhibitor / Unkown
HY-147527 CDK8-IN-5 Inhibitor / Unkown
HY-147717 CDK8-IN-7 Inhibitor / Unkown
HY-148561 CDK8-IN-12 Inhibitor / Unkown
HY-N0400R Wogonin (Standard) Inhibitor / Unkown
HY-151371 CDK8-IN-10 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk8 NCBI NCBI:1024