Parp14 - poly (ADP-ribose) polymerase family, member 14 Gene

Also Known as ARTD8; CoaSt6; mKIAA1268; 1600029O10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 547253

About Parp14

Chromosome 16: 35,653,244-35,691,914 reverse strand.GRCm39:CM001009.3

This gene has 3 transcripts (splice variants), 295 orthologues, 7 paralogues and is associated with 7 phenotypes. Broad expression in large intestine adult (RPKM 6.), bladder adult (RPKM 4.4) and 21 other tissues.

Summary

Predicted to enable several functions, including NAD+ binding activity; pentosyltransferase activity; and transcription corepressor activity. Involved in negative regulation of interferon-gamma-mediated signaling pathway and positive regulation of interleukin-4-mediated signaling pathway. Located in cytoplasm. Is expressed in Peyer's patch; hemolymphoid system; intestine; and urogenital sinus. Orthologous to human PARP14 (poly(ADP-ribose) polymerase family member 14). [provided by Alliance of Genome Resources, Apr 2022]

Parp14 Products (1)

mRNA Protein Name
NM_001039530.3 NP_001034619.2 protein mono-ADP-ribosyltransferase PARP14

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16537510 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of type II interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
27796300 MGI
involved in positive regulation of interleukin-4-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
27796300 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23473667 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Parp14 Protein Structure

RRM1_PAR14

RRM1_PAR14: cd12300 (5 - 86)

RRM_SF

RRM_SF: cl17169 (225 - 299)

Macro_Af1521_BAL-like

Macro_Af1521_BAL-like: cd02907 (811 - 969)

Macro_BAL-like

Macro_BAL-like: cd02903 (1021 - 1200)

Macro_BAL-like

Macro_BAL-like: cd02903 (1230 - 1396)

TCCD_inducible_PARP_like

TCCD_inducible_PARP_like: cd01439 (1694 - 1814)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1817 a.a.
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase PARP14

  • ADP-ribosyltransferase diphtheria toxin-like 8

  • PARP-14

  • collaborator of STAT6

  • poly [ADP-ribose] polymerase 14

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136979 RBN012759 Inhibitor 99.33% Unkown
HY-148566 OUL232 Inhibitor 99.86% Unkown
HY-150207 RBN-3143 Inhibitor 99.29% Unkown
HY-117889 PARP14 inhibitor H10 Inhibitor 99.46% Unkown
HY-108708 GeA-69 Inhibitor 99.91% Unkown
HY-148754 PARP10-IN-3 Inhibitor 98.72% Unkown
HY-173679 RBN012811 Degrader 98.79% Unkown
HY-155993 YCH1899 Inhibitor 99.39% Unkown
HY-148753 PARP10-IN-2 Inhibitor 98.02% Unkown
HY-121719 TIQ-A Inhibitor 99.85% Unkown
HY-143338 ART-IN-1 Inhibitor 98.91% Unkown
HY-W294889 OUL245 Inhibitor / Unkown
HY-172806 PARP14 inhibitor 1 Inhibitor / Unkown
HY-148709 ARTD10/PARP10-IN-1 Inhibitor / Unkown
HY-148710 ARTD10/PARP10-IN-2 Inhibitor / Unkown
HY-176456 PARP14 inhibitor 2 Inhibitor / Unkown
HY-183548 XW-17 Ligand / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Parp14 NCBI NCBI:54625