Atr - ATR serine/threonine kinase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 685055

About Atr

Primary_assembly 8: 96,426,724-96,524,136 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 209 orthologues, 5 paralogues and is associated with 19 phenotypes. Biased expression in Testes (RPKM 162.8), Thymus (RPKM 69.6) and 9 other tissues.

Summary

Predicted to enable MutLalpha complex binding activity; MutSalpha complex binding activity; and protein serine/threonine kinase activity. Involved in response to arsenic-containing substance and response to xenobiotic stimulus. Predicted to be located in Golgi apparatus; PML body; and XY body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic Cancer. Orthologous to human ATR (ATR serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Atr Products (3)

mRNA Protein Name
XM_006243600.4 XP_006243662.1 serine/threonine-protein kinase ATR isoform X2
XM_039082561.1 XP_038938489.1 serine/threonine-protein kinase ATR isoform X2
XM_003750561.5 XP_003750609.1 serine/threonine-protein kinase ATR isoform X1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in response to arsenic-containing substance IEP
IEP: Inferred from expression pattern
29097844 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19263217 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Atr Protein Structure

UME

UME: smart00802 (1119 - 1225)

FAT

FAT: pfam02259 (1765 - 2086)

TEL1

TEL1: cl34875 (2117 - 2635)

PIKKc_ATR

PIKKc_ATR: cd00892 (2284 - 2558)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2500
  • 2636 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase ATR

  • ataxia telangiectasia and Rad3 related

  • ataxia telangiectasia and rad3 related-like

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-19323 Ceralasertib Inhibitor 99.76% Phase 3
HY-13902 Berzosertib Inhibitor 99.67% Phase 2
HY-101566 Elimusertib Inhibitor 99.91% Phase 2
HY-139609 Camonsertib Inhibitor 99.99% Phase 2
HY-101566A Elimusertib hydrochloride Inhibitor 99.85% Phase 2

Pre-clinical Phase

Bioactive Molecules (31)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-14731 VE-821 Inhibitor 99.67% Unkown
HY-136270 Gartisertib Inhibitor 99.77% Unkown
HY-15557 AZ20 Inhibitor 99.40% Unkown
HY-15520 CGK733 Inhibitor 99.71% Unkown
HY-15521 ETP-46464 Inhibitor 99.54% Unkown
HY-N6954 Garcinone C Activator 99.51% Unkown
HY-159480 AD1058 Inhibitor 98.11% Unkown
HY-P10280 ATR kinase substrate peptide Substrate 99.30% Unkown
HY-161615 PROTAC ATR degrader-2 Degrader 99.73% Unkown
HY-13816 NU6027 Inhibitor 98.01% Unkown
HY-157767 Abd110 Inhibitor 98.67% Unkown
HY-147569 ATR-IN-17 Inhibitor / Unkown
HY-147567 ATR-IN-15 Inhibitor / Unkown
HY-147566 ATR-IN-14 Inhibitor / Unkown
HY-182017 ATR ligand 2 Ligand / Unkown
HY-13902A Berzosertib hydrochloride Inhibitor 98.77% Unkown
HY-161838 ICT10336 Inhibitor / Unkown
HY-182016 PROTAC ATR degrader-3 Degrader / Unkown
HY-151915 ATR-IN-20 Inhibitor / Unkown
HY-174828 ATR/PARP1-IN-1 Inhibitor / Unkown
HY-147568 ATR-IN-16 Inhibitor / Unkown
HY-153393 ATR-IN-21 Inhibitor / Unkown
HY-147190 ATR-IN-19 Inhibitor / Unkown
HY-144214 ATR-IN-10 Inhibitor / Unkown
HY-147570 ATR-IN-18 Inhibitor / Unkown
HY-147565 ATR-IN-13 Inhibitor / Unkown
HY-172247 ATR-IN-31 Inhibitor / Unkown
HY-153729 ATR-IN-29 Inhibitor / Unkown
HY-161616 ATR-IN-30 / Unkown
HY-141478 Antitumor agent-28 Inhibitor / Unkown
HY-N18301 Americanin A Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atr NCBI NCBI:545