UBE2D2 - ubiquitin conjugating enzyme E2 D2 Gene

Also Known as UBC4; PUBC1; UBCH4; UBC4/5; UBCH5B; E2(17)KB2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7322

About UBE2D2

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,526,240-139,628,434 (from NCBI)

This gene has 10 transcripts (splice variants), 140 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 32.5), brain (RPKM 24.1) and 25 other tissues.

Summary

Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of Enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) Enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

UBE2D2 Products (2)

mRNA Protein Name
NM_003339.3 NP_003330.1 ubiquitin-conjugating enzyme E2 D2 isoform 1
NM_181838.2 NP_862821.1 ubiquitin-conjugating enzyme E2 D2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14667819 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: Inferred from direct assay
14593114 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
8530467 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
18359941 GOA
Biological Process GO Annotation Evidence References Source
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
21068390 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
15247280 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
9990509 GOA
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
22797923 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2D2 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (5 - 141)

  • 0
  • 100
  • 147 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 D2

  • (E3-independent) E2 ubiquitin-conjugating enzyme D2

UBE2D2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBE2D2 P62837 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
UBE2D2 P62837 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
UBE2D2 P62837 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 OTUB1 Homo sapiens Q96FW1
Anti Tag CoIP
22124327
Intra
UBE2D2 P62837 OTUB1 Homo sapiens Q96FW1
Anti Tag CoIP
33961781
Intra
UBE2D2 P62837 OTUB1 Homo sapiens Q96FW1
Anti Tag CoIP
28514442
Intra
UBE2D2 P62837 OTUB1 Homo sapiens Q96FW1
Validated Y2H
32296183
Intra
UBE2D2 P62837 OTUB1 Homo sapiens Q96FW1
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 OTUB1 Homo sapiens Q96FW1
Y2H Array
32296183
Intra
UBE2D2 P62837 TRIM39 Homo sapiens Q9HCM9-2
Y2H Array
32296183
Intra
UBE2D2 P62837 TRIM39 Homo sapiens Q9HCM9-2
Validated Y2H
32296183
Intra
UBE2D2 P62837 TRIM39 Homo sapiens Q9HCM9-2
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 CHFR Homo sapiens Q96EP1-2
Y2H Array
32296183
Intra
UBE2D2 P62837 CHFR Homo sapiens Q96EP1-2
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 CHFR Homo sapiens Q96EP1-2
Validated Y2H
32296183
Intra
UBE2D2 P62837 RNF43 Homo sapiens Q68DV7
Y2H Array
19690564
Intra
UBE2D2 P62837 RNF25 Homo sapiens Q96BH1
Anti Tag CoIP
33961781
Intra
UBE2D2 P62837 RNF25 Homo sapiens Q96BH1
Anti Tag CoIP
28514442
Intra
UBE2D2 P62837 RNF25 Homo sapiens Q96BH1
Y2H Array
19549727
Intra
UBE2D2 P62837 RNF115 Homo sapiens Q9Y4L5
Validated Y2H
32296183
Intra
UBE2D2 P62837 RNF115 Homo sapiens Q9Y4L5
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 RNF115 Homo sapiens Q9Y4L5
Y2H Array
32296183
Intra
UBE2D2 P62837 ZNRF1 Homo sapiens Q8ND25
Y2H Array
19549727
Intra
UBE2D2 P62837 ZNRF1 Homo sapiens Q8ND25
Enzymatic Study
19549727
Intra
UBE2D2 P62837 ZNRF1 Homo sapiens Q8ND25
Validated Y2H
32296183
Intra
UBE2D2 P62837 ZNRF1 Homo sapiens Q8ND25
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 ZNRF1 Homo sapiens Q8ND25
Y2H Array
32296183
Intra
UBE2D2 P62837 ZNRF1 Homo sapiens Q8ND25
Y2H
19549727
Intra
UBE2D2 P62837 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra
UBE2D2 P62837 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra
UBE2D2 P62837 RNF185 Homo sapiens Q96GF1
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 RNF185 Homo sapiens Q96GF1
Y2H Array
32296183
Intra
UBE2D2 P62837 RNF185 Homo sapiens Q96GF1
Validated Y2H
32296183
Intra
UBE2D2 P62837 MID1 Homo sapiens O15344
Y2H Array
32296183
Intra
UBE2D2 P62837 MID1 Homo sapiens O15344
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 ARRDC3 Homo sapiens Q96B67
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 ARRDC3 Homo sapiens Q96B67
Validated Y2H
32296183
Intra
UBE2D2 P62837 ARRDC3 Homo sapiens Q96B67
Y2H Array
32296183
Intra
UBE2D2 P62837 RNF5 Homo sapiens Q99942
Y2H Array
19549727
Intra
UBE2D2 P62837 RNF5 Homo sapiens Q99942
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 RNF5 Homo sapiens Q99942
Y2H
19549727
Intra
UBE2D2 P62837 RNF5 Homo sapiens Q99942
Pull Down
20152160
Intra
UBE2D2 P62837 RNF5 Homo sapiens Q99942
Validated Y2H
32296183
Intra
UBE2D2 P62837 RNF5 Homo sapiens Q99942
Y2H Array
32296183
Intra
UBE2D2 P62837 TRAF6 Homo sapiens Q9Y4K3
Y2H Array
19549727
Intra
UBE2D2 P62837 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
32296183
Intra
UBE2D2 P62837 TRAF6 Homo sapiens Q9Y4K3
Y2H Array
32296183
Intra
UBE2D2 P62837 TRAF6 Homo sapiens Q9Y4K3
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 RNF8 Homo sapiens O76064
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 RNF8 Homo sapiens O76064
Y2H Array
32296183
Intra
UBE2D2 P62837 RNF11 Homo sapiens Q9Y3C5
Enzymatic Study
19549727
Intra
UBE2D2 P62837 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32296183
Intra
UBE2D2 P62837 RNF11 Homo sapiens Q9Y3C5
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32296183
Intra
UBE2D2 P62837 PHF7 Homo sapiens Q9BWX1
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 PHF7 Homo sapiens Q9BWX1
Validated Y2H
32296183
Intra
UBE2D2 P62837 PHF7 Homo sapiens Q9BWX1
Y2H Array
32296183
Intra
UBE2D2 P62837 XIAP Homo sapiens P98170
Enzymatic Study
19549727
Intra
UBE2D2 P62837 CUEDC1 Homo sapiens Q9NWM3
Validated Y2H
32296183
Intra
UBE2D2 P62837 CUEDC1 Homo sapiens Q9NWM3
Y2H Array
32296183
Intra
UBE2D2 P62837 CUEDC1 Homo sapiens Q9NWM3
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 RNF10 Homo sapiens Q8N5U6
Y2H Array
19549727
Intra
UBE2D2 P62837 RNF10 Homo sapiens Q8N5U6
Anti Tag CoIP
33961781
Intra
UBE2D2 P62837 RNF10 Homo sapiens Q8N5U6
Y2H
19549727
Intra
UBE2D2 P62837 RNF2 Homo sapiens Q99496
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 RNF2 Homo sapiens Q99496
Y2H Array
19549727
Intra
UBE2D2 P62837 RNF2 Homo sapiens Q99496
Validated Y2H
32296183
Intra
UBE2D2 P62837 RNF2 Homo sapiens Q99496
Y2H Array
32296183
Intra
UBE2D2 P62837 RNF114 Homo sapiens Q9Y508
Y2H
19549727
Intra
UBE2D2 P62837 RNF114 Homo sapiens Q9Y508
Anti Tag CoIP
33961781
Intra
UBE2D2 P62837 RNF114 Homo sapiens Q9Y508
Y2H Array
19549727
Intra
UBE2D2 P62837 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Intra
UBE2D2 P62837 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 DTX2 Homo sapiens Q86UW9
Y2H Array
32296183
Intra
UBE2D2 P62837 UBTD1 Homo sapiens Q9HAC8
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 UBTD1 Homo sapiens Q9HAC8
Validated Y2H
32296183
Intra
UBE2D2 P62837 UBTD1 Homo sapiens Q9HAC8
Y2H Array
32296183
Intra
UBE2D2 P62837 RING1 Homo sapiens Q06587
Y2H Array
32296183
Intra
UBE2D2 P62837 RING1 Homo sapiens Q06587
Y2H Prey Pooling
32296183
Intra
UBE2D2 P62837 RING1 Homo sapiens Q06587
Y2H Array
19549727
Intra
UBE2D2 P62837 RING1 Homo sapiens Q06587
Validated Y2H
32296183
Intra
UBE2D2 P62837 TRIM50 Homo sapiens Q86XT4
Y2H Array
32296183
Intra
UBE2D2 P62837 TRIM50 Homo sapiens Q86XT4
Validated Y2H
32296183
Intra
UBE2D2 P62837 TRIM50 Homo sapiens Q86XT4
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2D2 Proteins

Cat. No. Product Name Accession Purity
HY-P79449 UbcH5b/UBE2D2 Protein, Human P62837-1 (M1-M147) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Machado-Joseph Disease

  • SCA3

  • MJD

  • Spinocerebellar Ataxia 3

  • Azorean Disease

  • Spinocerebellar Ataxia Type 3

  • Spinocerebellar Atrophy

  • Azorean Neurologic Disease

  • Spinopontine Atrophy

  • Nigrospinodentatal Degeneration

  • Spinocerebellar Atrophy Iii

  • Spinocerebellar Atrophy Type 3

  • Azorean Ataxia

  • Azorean Disease Of The Nervous System

  • Machado Disease

  • Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

  • Disease, Machado-Joseph

  • Ataxia, Spinocerebellar
Brachydactyly, Type E2

  • Brachydactyly Type E2

  • BDE2

  • Brachydactyly E2
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS24680 Ube2d2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15340 UBE2D2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UBE2D2 MGD MGI:1930715
Bos taurus UBE2D2 VGNC VGNC:36580
Macaca mulatta UBE2D2 VGNC VGNC:84510
Rattus norvegicus UBE2D2 RGD RGD:1591897
Canis familiaris UBE2D2 VGNC VGNC:48051
Others UBE2D2 NCBI