1. Gene
  2. YWHAH - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta Gene

YWHAH - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta Gene

Homo sapiens

Also known as YWHA1

Gene ID: 7533 | Gene type: protein coding

About YWHAH

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:31,944,535-31,957,603 (from NCBI)

This gene has 6 transcripts (splice variants), 124 orthologues and 6 paralogues. Broad expression in brain (RPKM 343.5), lung (RPKM 62.6) and 22 other tissues.

Summary

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both Plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]

YWHAH Products(1)

mRNA Protein Name
NM_003405.4 NP_003396.1 2014/3/3 protein eta

YWHAH Protein Structure

14-3-3

14-3-3: 14-3-3 protein (4 - 241)

  • 0
  • 100
  • 200
  • 246 a.a.
Protein Preferred Names Protein Names

14-3-3 protein eta

14-3-3 eta

Recombinant YWHAH Proteins

Cat. No. Product Name Accession Purity
HY-P71682 YWHAH Protein, Human (GST) Q04917 (R4-N246) ≥95%

Related Diseases

Diseases Alias
Early-Onset Schizophrenia

Early Onset Schizophrenia

Deafness, Autosomal Dominant 64

DFNA64

Autosomal Dominant Nonsyndromic Deafness 64

Autosomal Dominant Deafness 64

Deafness, Autosomal Dominant, 64

Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 64

Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 64

Deafness, Autosomal Dominant, Type 64

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Small Intestine Leiomyosarcoma

Leiomyosarcoma Of The Small Bowel

Smooth Muscle Connective Tissue Tumor

Leiomyosarcoma Of Small Intestine

Neurofibromatosis, Type I

Von Recklinghausen Disease

Neurofibromatosis 1

Neurofibromatosis, Type 1

NF1

Neurofibromatosis, Peripheral Type

Neurofibromatosis Type I

Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion

Familial Spinal Neurofibromatosis

Fsnf

Peripheral Neurofibromatosis

Von Recklinghausen'S Neurofibromatosis

Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion

Neurofibromatosis Peripheral Type

Von Recklinghausen Syndrome

Neurofibromatosis Type 1

Von Recklinghausen Neuropathy

Nf1 - [Neurofibromatosis Type 1]

Recklinghausen Disease

Sudden Infant Death Syndrome

SIDS

Sudden Infant Death Syndrome, Susceptibility To

Cot Death

Crib Death

Sudden Death Of Nonspecific Cause In Infancy

Sudden Infant Death

Death, Sudden, Syndrome, Infant

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris YWHAH VGNC VGNC:52975
Macaca mulatta YWHAH VGNC VGNC:78821
Mus musculus YWHAH MGD MGI:109194
Felis catus YWHAH VGNC VGNC:67156
Bos taurus YWHAH VGNC VGNC:97330
Rattus norvegicus YWHAH RGD RGD:3978
Others YWHAH NCBI