YWHAH - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta Gene
Also Known as YWHA1
Species: Homo sapiens
About YWHAH
This gene has 6 transcripts (splice variants), 124 orthologues and 6 paralogues. Broad expression in brain (RPKM 343.5), lung (RPKM 62.6) and 22 other tissues.
Summary
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both Plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]
YWHAH Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_003405.4 | NP_003396.1 | 2014/3/3 protein eta |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables enzyme binding |
IPI
IPI: Inferred from physical interaction
|
17255105 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
17085597 | GOA |
| enables nuclear glucocorticoid receptor binding |
IPI
IPI: Inferred from physical interaction
|
9079630 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10713667 | GOA |
| enables protein heterodimerization activity |
IPI
IPI: Inferred from physical interaction
|
11953308 | GOA |
| enables sodium channel regulator activity |
IDA
IDA: Inferred from direct assay
|
16728661 | GOA |
| enables transmembrane transporter binding |
IPI
IPI: Inferred from physical interaction
|
11953308 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in glucocorticoid catabolic process |
IDA
IDA: Inferred from direct assay
|
15790729 | GOA |
| involved in membrane depolarization during action potential |
IDA
IDA: Inferred from direct assay
|
16728661 | GOA |
| involved in nuclear receptor-mediated glucocorticoid signaling pathway |
IDA
IDA: Inferred from direct assay
|
15790729 | GOA |
| involved in positive regulation of DNA-templated transcription |
IDA
IDA: Inferred from direct assay
|
15790729 | GOA |
| involved in regulation of sodium ion transmembrane transporter activity |
IDA
IDA: Inferred from direct assay
|
16728661 | GOA |
| involved in regulation of sodium ion transport |
IDA
IDA: Inferred from direct assay
|
16728661 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in mitochondrion |
IDA
IDA: Inferred from direct assay
|
31906564 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
16728661 | GOA |
YWHAH Protein Structure
14-3-3: 14-3-3 protein (4 - 241)
- 0
- 100
- 200
- 246 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
14-3-3 protein eta |
|
YWHAH Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
YWHAH | Q04917 | CDK14 | Homo sapiens | O94921 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | CDK14 | Homo sapiens | O94921 | 16775625 | |
|
Intra
|
YWHAH | Q04917 | CDK14 | Homo sapiens | O94921 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | CCNY | Homo sapiens | Q8ND76 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | CDC25B | Homo sapiens | P30305 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | CDC25B | Homo sapiens | P30305 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | CDC25B | Homo sapiens | P30305 | 10713667 | |
|
Intra
|
YWHAH | Q04917 | INPP5E | Homo sapiens | Q9NRR6 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | INPP5E | Homo sapiens | Q9NRR6 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | INPP5E | Homo sapiens | Q9NRR6 | 35271311 | |
|
Intra
|
YWHAH | Q04917 | CCDC125 | Homo sapiens | Q86Z20 | 32296183 | |
|
Intra
|
YWHAH | Q04917 | PRKD2 | Homo sapiens | Q9BZL6 | 17962809 | |
|
Intra
|
YWHAH | Q04917 | PRKD2 | Homo sapiens | Q9BZL6 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | PRR5 | Homo sapiens | P85299 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | PRR5 | Homo sapiens | P85299 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | SSX2IP | Homo sapiens | Q9Y2D8 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | SSX2IP | Homo sapiens | Q9Y2D8 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | SSX2IP | Homo sapiens | Q9Y2D8 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | SPG11 | Homo sapiens | Q96JI7 | 37871017 | |
|
Intra
|
YWHAH | Q04917 | NHSL2 | Homo sapiens | Q5HYW2 | 32296183 | |
|
Intra
|
YWHAH | Q04917 | PRKCI | Homo sapiens | P41743 | 14676191 | |
|
Intra
|
YWHAH | Q04917 | PRKCI | Homo sapiens | P41743 | 17979178 | |
|
Intra
|
YWHAH | Q04917 | PRKCI | Homo sapiens | P41743 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | PARD6B | Homo sapiens | Q9BYG5 | 14676191 | |
|
Intra
|
YWHAH | Q04917 | PARD6G | Homo sapiens | Q9BYG4 | 14676191 | |
|
Intra
|
YWHAH | Q04917 | MARK4 | Homo sapiens | Q96L34 | 16959763 | |
|
Intra
|
YWHAH | Q04917 | MARK4 | Homo sapiens | Q96L34 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | MARK4 | Homo sapiens | Q96L34 | 14676191 | |
|
Intra
|
YWHAH | Q04917 | RAF1 | Homo sapiens | P04049 | 26496610 | |
|
Intra
|
YWHAH | Q04917 | RAF1 | Homo sapiens | P04049 | 33961781 | |
|
Intra
|
YWHAH | Q04917 | RAF1 | Homo sapiens | P04049 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | RAF1 | Homo sapiens | P04049 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | RAF1 | Homo sapiens | P04049 | 17979178 | |
|
Intra
|
YWHAH | Q04917 | RAF1 | Homo sapiens | P04049 | 11697890 | |
|
Intra
|
YWHAH | Q04917 | RAF1 | Homo sapiens | P04049 | 35271311 | |
|
Intra
|
YWHAH | Q04917 | MAP3K3 | Homo sapiens | Q99759 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | MAP3K3 | Homo sapiens | Q99759 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | MAP3K3 | Homo sapiens | Q99759 | 33961781 | |
|
Intra
|
YWHAH | Q04917 | HDAC4 | Homo sapiens | P56524 | 18045992 | |
|
Intra
|
YWHAH | Q04917 | HDAC4 | Homo sapiens | P56524 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | HDAC4 | Homo sapiens | P56524 | 33961781 | |
|
Intra
|
YWHAH | Q04917 | HDAC4 | Homo sapiens | P56524 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | HDAC4 | Homo sapiens | P56524 | 26496610 | |
|
Intra
|
YWHAH | Q04917 | HDAC4 | Homo sapiens | P56524 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | HDAC4 | Homo sapiens | P56524 | 17979178 | |
|
Intra
|
YWHAH | Q04917 | YWHAE | Homo sapiens | P62258 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | YWHAE | Homo sapiens | P62258 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | YWHAE | Homo sapiens | P62258 | 26496610 | |
|
Intra
|
YWHAH | Q04917 | YWHAE | Homo sapiens | P62258 | 35271311 | |
|
Intra
|
YWHAH | Q04917 | YWHAE | Homo sapiens | P62258 | 20936779 | |
|
Intra
|
YWHAH | Q04917 | YWHAE | Homo sapiens | P62258 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | YWHAE | Homo sapiens | P62258 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | YWHAE | Homo sapiens | P62258 | 33961781 | |
|
Intra
|
YWHAH | Q04917 | NEK1 | Homo sapiens | Q96PY6 | 33961781 | |
|
Intra
|
YWHAH | Q04917 | NEK1 | Homo sapiens | Q96PY6 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | NEK1 | Homo sapiens | Q96PY6 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | NEK1 | Homo sapiens | Q96PY6 | 14690447 | |
|
Intra
|
YWHAH | Q04917 | NEK1 | Homo sapiens | Q96PY6 | 35271311 | |
|
Intra
|
YWHAH | Q04917 | FGD6 | Homo sapiens | Q6ZV73 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | FGD6 | Homo sapiens | Q6ZV73 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | FGD6 | Homo sapiens | Q6ZV73 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | MAP3K5 | Homo sapiens | Q99683 | 33961781 | |
|
Intra
|
YWHAH | Q04917 | MAP3K5 | Homo sapiens | Q99683 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | MARK2 | Homo sapiens | Q7KZI7 | 17979178 | |
|
Intra
|
YWHAH | Q04917 | MARK2 | Homo sapiens | Q7KZI7 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | MARK2 | Homo sapiens | Q7KZI7 | 14676191 | |
|
Intra
|
YWHAH | Q04917 | MARK2 | Homo sapiens | Q7KZI7 | 33961781 | |
|
Intra
|
YWHAH | Q04917 | MARK2 | Homo sapiens | Q7KZI7 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | MARK2 | Homo sapiens | Q7KZI7 | 16959763 | |
|
Intra
|
YWHAH | Q04917 | MARK2 | Homo sapiens | Q7KZI7 | 19553522 | |
|
Intra
|
YWHAH | Q04917 | MARK2 | Homo sapiens | Q7KZI7 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | MARK2 | Homo sapiens | Q7KZI7 | 35271311 | |
|
Intra
|
YWHAH | Q04917 | CBL | Homo sapiens | P22681 | 33961781 | |
|
Intra
|
YWHAH | Q04917 | CBL | Homo sapiens | P22681 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | CBL | Homo sapiens | P22681 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | CBL | Homo sapiens | P22681 | 11697890 | |
|
Intra
|
YWHAH | Q04917 | KANK1 | Homo sapiens | Q14678-2 | 18458160 | |
|
Intra
|
YWHAH | Q04917 | CAMKK1 | Homo sapiens | Q8N5S9 | 18242179 | |
|
Intra
|
YWHAH | Q04917 | CAMKK1 | Homo sapiens | Q8N5S9 | 18242179 | |
|
Intra
|
YWHAH | Q04917 | CAMKK1 | Homo sapiens | Q8N5S9 | 36931259 | |
|
Cross
|
YWHAH | Q04917 | Rnd3 | Mus musculus | P61588 | 23622247 | |
|
Intra
|
YWHAH | Q04917 | BAD | Homo sapiens | Q92934 | 33961781 | |
|
Intra
|
YWHAH | Q04917 | BAD | Homo sapiens | Q92934 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | BAD | Homo sapiens | Q92934 | 21988832 | |
|
Intra
|
YWHAH | Q04917 | BAD | Homo sapiens | Q92934 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | BAD | Homo sapiens | Q92934 | 17979178 | |
|
Intra
|
YWHAH | Q04917 | MARK3 | Homo sapiens | P27448 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | MARK3 | Homo sapiens | P27448 | 14676191 | |
|
Intra
|
YWHAH | Q04917 | MARK3 | Homo sapiens | P27448 | 17979178 | |
|
Intra
|
YWHAH | Q04917 | MARK3 | Homo sapiens | P27448 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | MARK3 | Homo sapiens | P27448 | 35271311 | |
|
Intra
|
YWHAH | Q04917 | MARK3 | Homo sapiens | P27448 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | MARK3 | Homo sapiens | P27448 | 33961781 | |
|
Intra
|
YWHAH | Q04917 | NEDD4L | Homo sapiens | Q96PU5 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | NEDD4L | Homo sapiens | Q96PU5 | 15677482 | |
|
Intra
|
YWHAH | Q04917 | NEDD4L | Homo sapiens | Q96PU5 | 33961781 | |
|
Intra
|
YWHAH | Q04917 | NEDD4L | Homo sapiens | Q96PU5 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | NEDD4L | Homo sapiens | Q96PU5 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | AKT1S1 | Homo sapiens | Q96B36 | 17979178 | |
|
Intra
|
YWHAH | Q04917 | AKT1S1 | Homo sapiens | Q96B36 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | AKT1S1 | Homo sapiens | Q96B36 | 33961781 | |
|
Intra
|
YWHAH | Q04917 | AKT1S1 | Homo sapiens | Q96B36 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | PLK4 | Homo sapiens | O00444 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | CSNK1E | Homo sapiens | P49674 | 19860830 | |
|
Intra
|
YWHAH | Q04917 | CSNK1E | Homo sapiens | P49674 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | CSNK1E | Homo sapiens | P49674 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | PARD6A | Homo sapiens | Q9NPB6 | 14676191 | |
|
Intra
|
YWHAH | Q04917 | PARD3 | Homo sapiens | Q8TEW0 | 33961781 | |
|
Intra
|
YWHAH | Q04917 | PARD3 | Homo sapiens | Q8TEW0 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | PARD3 | Homo sapiens | Q8TEW0 | 14676191 | |
|
Intra
|
YWHAH | Q04917 | PARD3 | Homo sapiens | Q8TEW0 | 17979178 | |
|
Intra
|
YWHAH | Q04917 | PARD3 | Homo sapiens | Q8TEW0 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | PARD3 | Homo sapiens | Q8TEW0 | 35271311 | |
|
Intra
|
YWHAH | Q04917 | PARD3 | Homo sapiens | Q8TEW0 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | ATXN1 | Homo sapiens | P54253 | 28514442 | |
|
Intra
|
YWHAH | Q04917 | ATXN1 | Homo sapiens | P54253 | 36931259 | |
|
Intra
|
YWHAH | Q04917 | SNCA | Homo sapiens | P37840-1 | 24895406 | |
|
Intra
|
YWHAH | Q04917 | SNCA | Homo sapiens | P37840-1 | 24895406 | |
|
Intra
|
YWHAH | Q04917 | SNCA | Homo sapiens | P37840-1 | 24895406 | |
|
Intra
|
YWHAH | Q04917 | SNCA | Homo sapiens | P37840-1 | 24895406 | |
|
Intra
|
YWHAH | Q04917 | SNCA | Homo sapiens | P37840 | 24895406 |
Recombinant YWHAH Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P71682 | 14-3-3 eta Protein, Human (GST) | Q04917 (R4-N246) | ≥ 90%, as determined by reducing SDS-PAGE. |
YWHAH Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80525 | 14-3-3 eta Antibody (YA838) | WB | Human, Mouse, Rat |
| HY-P80525A | 14-3-3 eta Antibody (YA838)(PBS only) | WB | Human, Mouse, Rat |
| HY-P85780 | 14-3-3 eta Antibody (YA5472) | WB, IHC-P | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Early-Onset Schizophrenia |
|
|
| Deafness, Autosomal Dominant 64 |
|
|
| Bipolar Disorder |
|
|
| Schizophrenia |
|
|
| Small Intestine Leiomyosarcoma |
|
|
| Neurofibromatosis, Type I |
|
|
| Sudden Infant Death Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | YWHAH | VGNC | VGNC:52975 |
| Macaca mulatta | YWHAH | VGNC | VGNC:78821 |
| Mus musculus | YWHAH | MGD | MGI:109194 |
| Felis catus | YWHAH | VGNC | VGNC:67156 |
| Bos taurus | YWHAH | VGNC | VGNC:97330 |
| Rattus norvegicus | YWHAH | RGD | RGD:3978 |
| Others | YWHAH | NCBI |