Atf4 - activating transcription factor 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 79255

Summary

Enables DNA-binding transcription factor binding activity; general transcription initiation factor binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to oxygen-glucose deprivation; positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress; and response to manganese-induced endoplasmic reticulum stress. Located in cytoplasm; dendrite membrane; and nucleus. Biomarker of borna disease and pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Atf4 Products (1)

mRNA Protein Name
NM_024403.2 NP_077379.1 cyclic AMP-dependent transcription factor ATF-4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
18171674 RGD
enables general transcription initiation factor binding IPI
IPI: Inferred from physical interaction
18171674 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10924501 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
20444431 RGD
involved in cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
23392669 RGD
involved in gamma-aminobutyric acid signaling pathway IDA
IDA: Inferred from direct assay
10924501 RGD
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
23392669 RGD
involved in negative regulation of potassium ion transport IMP
IMP: Inferred from mutant phenotype
10924501 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
19322020 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23392669 RGD
involved in response to manganese-induced endoplasmic reticulum stress IEP
IEP: Inferred from expression pattern
23934647 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
20026213 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite membrane IDA
IDA: Inferred from direct assay
10924501 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclic AMP-dependent transcription factor ATF-4

  • activating transcription factor 4 (tax-responsive enhancer element B67)

  • activating transcription factor ATF-4

  • cAMP-dependent transcription factor ATF-4

  • rATF-4

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-13559 Atiprimod / Phase 2
HY-13559A Atiprimod dimaleate / Phase 2
HY-160196 HC-7366 Inhibitor 99.58% Phase 1

Pre-clinical Phase

Bioactive Molecules (44)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112654 GCN2iB 99.83% Unkown
HY-100355 C18-Ceramide (d18:1/18:0) 99.95% Unkown
HY-100548 GSK621 98.03% Unkown
HY-158201 ATF4-IN-1 Activator 99.29% Unkown
HY-158202 ATF4-IN-2 Inhibitor 99.24% Unkown
HY-170872 PT-129 98.66% Unkown
HY-147831 HR-19011 99.64% Unkown
HY-153339 E235 Activator 99.86% Unkown
HY-153340 I-152 Activator 98.78% Unkown
HY-W020952 Palladium(Ⅱ) acetylacetonate 98.2% Unkown
HY-112056 DIM-C-pPhCO2Me 99.47% Unkown
HY-158196 PERK/eIF2α activator 1 Activator 98.88% Unkown
HY-153074 ISR-IN-1 Inhibitor 98.92% Unkown
HY-153075 ISR-IN-2 / Unkown
HY-158203 BMP agonist 2 Agonist 99.26% Unkown
HY-121337 Flurochloridone 99.61% Unkown
HY-124646 KIRA-7 Inhibitor 99.09% Unkown
HY-RS01130 ATF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-178154 FB231 99.45% Unkown
HY-181959 APL-4098 Inhibitor / Unkown
HY-149918 Antiproliferative agent-23 / Unkown
HY-112654A GCN2iB acetate / Unkown
HY-117938 T-3861174 Inhibitor / Unkown
HY-121033 BS148 / Unkown
HY-158195 DPP23 Inducer 99.55% Unkown
HY-158205 HPO-DAEE / Unkown
HY-162886 BSO-07 Activator / Unkown
HY-170849 Nur77 modulator 4 Inducer / Unkown
HY-171438 ATF4 agonist-1 / Unkown
HY-172784 Anticancer agent 273 / Unkown
HY-180490 eIF3e-IN-1 Inhibitor / Unkown
HY-182360 Cytisine-platinum(IV) prodrug-1 / Unkown
HY-182781 Anticancer agent 313 Inhibitor / Unkown
HY-182938 Autophagy activator-2 Activator / Unkown
HY-183331 YXX0237 Activator / Unkown
HY-183332 YXX0248 Activator / Unkown
HY-183704 ISR activator-5 / Unkown
HY-P5762A Phoenixin-14 TFA / Unkown
HY-110102 Atiprimod hydrochloride / Unkown
HY-112903A YW3-56 hydrochloride / Unkown
HY-138844 3-AP-Me Activator / Unkown
HY-183004 NCP26 / Unkown
HY-RS16552 Atf4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22985 Atf4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atf4 NCBI NCBI:468