2. Gene
  3. Mmp14 - matrix metallopeptidase 14 Gene

Mmp14 - matrix metallopeptidase 14 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Mt1-mmp

Gene ID: 81707 | Gene type: protein coding

About Mmp14

Primary_assembly 15: 27,887,727-27,899,864 forward strand.mRatBN7.2:CM026988.1

This gene has 3 transcripts (splice variants), 272 orthologues, 23 paralogues and is associated with 34 phenotypes. Biased expression in Uterus (RPKM 594.1), Adrenal (RPKM 38.8) and 9 other tissues.

Summary

Enables Integrin binding activity. Involved in several processes, including gonad development; negative regulation of focal adhesion assembly; and response to odorant. Located in cytoplasm. Used to study ischemia. Biomarker of IgA glomerulonephritis; anti-basement membrane glomerulonephritis; artery disease (multiple); brain ischemia; and congestive heart failure. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14). [provided by Alliance of Genome Resources, Apr 2022]

Mmp14 Products(1)

mRNA Protein Name
NM_031056.1 NP_112318.1 matrix metalloproteinase-14 precursor

Mmp14 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (35 - 87)

Peptidase_M10

Peptidase_M10: pfam00413 (117 - 283)

HX

HX: cd00094 (315 - 507)

DUF3377

DUF3377: cl13321 (559 - 581)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 582 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-14

MMP-14

MT-MMP 1

MT1MMP

MTMMP1

matrix metallopeptidase 14 (membrane-inserted)

matrix metalloproteinase 14 membrane-inserted

membrane type 1-matrix metalloproteinase

membrane-type matrix metalloproteinase 1

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12169 Marimastat Inhibitor ≥98.0% Phase 3
Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15827 NSC 405020 Inhibitor 99.67% Unkown
HY-110397 KP-457 Inhibitor 99.18% Unkown
HY-107394 UK 356618 Inhibitor 98.91% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-124373 ND-336 Inhibitor ≥95.0% Unkown
HY-P3120 Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 / Unkown
HY-114785 BPHA Inhibitor / Unkown
HY-124373A (R)-ND-336 Inhibitor / Unkown
HY-162038 RXP03 Inhibitor / Unkown
HY-RS08528 MMP14 Human Pre-designed siRNA Set A / Unkown
HY-RS08529 Mmp14 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08530 Mmp14 Rat Pre-designed siRNA Set A / Unkown
HY-E70290 N-Acetylgalactosaminyltransferase 1 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp14 NCBI NCBI:4323