Mmp14 - matrix metallopeptidase 14 Gene

Also Known as Mt1-mmp

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81707

About Mmp14

Primary_assembly 15: 27,887,727-27,899,864 forward strand.mRatBN7.2:CM026988.1

This gene has 3 transcripts (splice variants), 272 orthologues, 23 paralogues and is associated with 34 phenotypes. Biased expression in Uterus (RPKM 594.1), Adrenal (RPKM 38.8) and 9 other tissues.

Summary

Enables Integrin binding activity. Involved in several processes, including gonad development; negative regulation of focal adhesion assembly; and response to odorant. Located in cytoplasm. Used to study ischemia. Biomarker of IgA glomerulonephritis; anti-basement membrane glomerulonephritis; artery disease (multiple); brain ischemia; and congestive heart failure. Human ortholog(s) of this gene implicated in Winchester syndrome; esophagus adenocarcinoma; and myocardial infarction. Orthologous to human MMP14 (matrix metallopeptidase 14). [provided by Alliance of Genome Resources, Apr 2022]

Mmp14 Products (1)

mRNA Protein Name
NM_031056.1 NP_112318.1 matrix metalloproteinase-14 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables integrin binding IPI
IPI: Inferred from physical interaction
19027888 RGD
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IEP
IEP: Inferred from expression pattern
14766216 RGD
involved in astrocyte cell migration IEP
IEP: Inferred from expression pattern
16265672 RGD
involved in endothelial cell proliferation IEP
IEP: Inferred from expression pattern
14766216 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
22152881 RGD
involved in negative regulation of focal adhesion assembly IDA
IDA: Inferred from direct assay
15044209 RGD
involved in ossification IEP
IEP: Inferred from expression pattern
15883642 RGD
involved in ovarian follicle development IEP
IEP: Inferred from expression pattern
15617683 RGD
involved in positive regulation of protein processing IMP
IMP: Inferred from mutant phenotype
14668206 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
15053235 RGD
involved in response to hormone IDA
IDA: Inferred from direct assay
14668206 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
16980344 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
15350851 RGD
involved in response to odorant IEP
IEP: Inferred from expression pattern
23103411 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
11125539 RGD
involved in response to oxidative stress IEP
IEP: Inferred from expression pattern
15642321 RGD
involved in tissue remodeling IDA
IDA: Inferred from direct assay
16740171 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp14 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (35 - 87)

Peptidase_M10

Peptidase_M10: pfam00413 (117 - 283)

HX

HX: cd00094 (315 - 507)

DUF3377

DUF3377: cl13321 (559 - 581)

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  • 500
  • 582 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-14

  • MMP-14

  • MT-MMP 1

  • MT1MMP

  • MTMMP1

  • matrix metallopeptidase 14 (membrane-inserted)

  • matrix metalloproteinase 14 membrane-inserted

  • membrane type 1-matrix metalloproteinase

  • membrane-type matrix metalloproteinase 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12169 Marimastat Inhibitor 99.90% Phase 3
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990045 Lixudebart Inhibitor 98.88% Phase 2

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15827 NSC 405020 Inhibitor 99.63% Unkown
HY-110397 KP-457 Inhibitor 98.88% Unkown
HY-107394 UK 356618 Inhibitor 98.91% Unkown
HY-124373 ND-336 Inhibitor 97.16% Unkown
HY-162038 RXP03 Inhibitor 98.82% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-E70290 N-Acetylgalactosaminyltransferase 1 Agonist / Unkown
HY-110397G KP-457 (GMP) Inhibitor / Unkown
HY-N6812 Karacoline 99.58% Unkown
HY-114785 BPHA Inhibitor 99.88% Unkown
HY-RS08528 MMP14 Human Pre-designed siRNA Set A / Unkown
HY-P3120 Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 Substrate 96.30% Unkown
HY-124373A (R)-ND-336 Inhibitor / Unkown
HY-160720 ASPH-IN-1 Inhibitor / Unkown
HY-P3120A Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA Substrate / Unkown
HY-RS08529 Mmp14 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08530 Mmp14 Rat Pre-designed siRNA Set A / Unkown
HY-35513 3-Aminobenzene-1,2-diol Inhibitor 98.0% Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991316 KD014 96.98% Unkown
HY-P991478 RLVT-14-02 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp14 NCBI NCBI:4323