Dnmt1 - DNA methyltransferase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84350

About Dnmt1

Primary_assembly 8: 19,440,611-19,486,659 reverse strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 215 orthologues, 1 paralogue and is associated with 71 phenotypes. Biased expression in Thymus (RPKM 213.6), Spleen (RPKM 125.4) and 9 other tissues.

Summary

Enables several functions, including DNA (cytosine-5-)-methyltransferase activity; Estrogen receptor binding activity; and histone deacetylase binding activity. Involved in several processes, including DNA metabolic process; cellular response to growth factor stimulus; and nervous system development. Located in cytoplasm; neuronal cell body; and nucleus. Part of protein-containing complex. Used to study choline deficiency disease and lung carcinoma. Biomarker of choline deficiency disease; congenital heart disease; congestive heart failure; liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; hereditary sensory neuropathy type 1E; and lung non-small cell carcinoma. Orthologous to human DNMT1 (DNA Methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Dnmt1 Products (1)

mRNA Protein Name
NM_053354.3 NP_445806.3 DNA (cytosine-5)-methyltransferase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA (cytosine-5-)-methyltransferase activity IDA
IDA: Inferred from direct assay
12473678 RGD
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
12473678 RGD
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
19683557 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
12473678 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to lead ion IEP
IEP: Inferred from expression pattern
22764079 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
10407183 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: Inferred from expression pattern
23423710 RGD
involved in cellular response to transforming growth factor beta stimulus IMP
IMP: Inferred from mutant phenotype
24211420 RGD
involved in negative regulation of gene expression via chromosomal CpG island methylation IDA
IDA: Inferred from direct assay
12473678 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
19660178 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
23201423 RGD
involved in response to alcohol IEP
IEP: Inferred from expression pattern
26509893 RGD
involved in response to bisphenol A IEP
IEP: Inferred from expression pattern
23791455 RGD
involved in response to caffeine IEP
IEP: Inferred from expression pattern
24717552 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
22334722 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
24968059 RGD
involved in response to ionizing radiation IEP
IEP: Inferred from expression pattern
17148264 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
23246732 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
23271618 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
24270982 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
20056826 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
23433207 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
23333085 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
22880885 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16632870 RGD
involved in response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
32051532 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22880885 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
12473678 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dnmt1 Protein Structure

DMAP_binding

DMAP_binding: pfam06464 (15 - 105)

PRK12678

PRK12678: cl36163 (108 - 326)

DNMT1-RFD

DNMT1-RFD: pfam12047 (404 - 539)

zf-CXXC

zf-CXXC: pfam02008 (648 - 694)

BAH_Dnmt1_I

BAH_Dnmt1_I: cd04760 (758 - 880)

BAH_Dnmt1_II

BAH_Dnmt1_II: cd04711 (968 - 1104)

Dcm

Dcm: COG0270 (1141 - 1594)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1621 a.a.
Protein Preferred Names Protein Names

DNA (cytosine-5)-methyltransferase 1

  • DNA (cytosine-5-)-methyltransferase 1

  • DNA MTase RnoIP

  • DNA methyltransferase (cytosine-5) 1

  • DNA methyltransferase I

  • MCMT

  • m.RnoIP

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0004 Decitabine Inhibitor 99.97% Yes
HY-10586 5-Azacytidine Inhibitor 99.91% Yes
HY-B2194 γ-Oryzanol Inhibitor 99.66% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-112288 C188-9 Inhibitor 99.84% Phase 2
HY-139015 5-Aza-4'-thio-2'-deoxycytidine Inhibitor 99.89% Phase 2

Pre-clinical Phase

Bioactive Molecules (27)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135146 GSK-3484862 Inhibitor 99.95% Unkown
HY-13642 RG108 Inhibitor 99.93% Unkown
HY-13962 SGI-1027 Inhibitor 99.79% Unkown
HY-13420 Zebularine Inhibitor 99.49% Unkown
HY-B2230 Hinokitiol Inhibitor 99.90% Unkown
HY-101925 CM-272 Inhibitor 99.55% Unkown
HY-15229 Guadecitabine sodium Inhibitor 99.97% Unkown
HY-12746 DC-05 Inhibitor 99.04% Unkown
HY-117421A CM-579 trihydrochloride Inhibitor 97.00% Unkown
HY-12747 DC_517 Inhibitor 99.33% Unkown
HY-139664A (R)-GSK-3685032 Inhibitor 98.97% Unkown
HY-135146A (Rac)-GSK-3484862 Inhibitor 98.76% Unkown
HY-173002 MS9024 Degrader 99.83% Unkown
HY-179409 MC3817 Inhibitor 99.88% Unkown
HY-181955 MS1129 Degrader / Unkown
HY-117421 CM-579 Inhibitor / Unkown
HY-19826 Isofistularin-3 Inhibitor / Unkown
HY-182009 DNMT-IN-6 Inhibitor / Unkown
HY-179409A MC3817 free base Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-175988 DNMT/HDAC-IN-2 Inhibitor / Unkown
HY-172217 DNMT1-IN-5 Inhibitor / Unkown
HY-183852 GSK3830052 Inhibitor / Unkown
HY-13642G RG108 (GMP) Inhibitor / Unkown
HY-135146G GSK-3484862 (GMP) Inhibitor / Unkown
HY-161694 DNMT1-IN-3 Inhibitor / Unkown
HY-182956 DNMT1 Degrader-1 Degrader / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnmt1 NCBI NCBI:1786