PKMYT1 - protein kinase, membrane associated tyrosine/threonine 1 Gene

Also Known as MYT1; PPP1R126

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9088

About PKMYT1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,972,808-2,980,446 (from NCBI)

This gene has 20 transcripts (splice variants), 181 orthologues and 8 paralogues. Broad expression in testis (RPKM 14.8), bone marrow (RPKM 10.4) and 16 other tissues.

Summary

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

PKMYT1 Products (4)

mRNA Protein Name
NM_001258450.2 NP_001245379.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3
NM_001258451.2 NP_001245380.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 4
NM_004203.5 NP_004194.3 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 1
NM_182687.3 NP_872629.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables kinase activity IDA
IDA: Inferred from direct assay
9268380 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10373560 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9268380 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of G2/M transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
9268380 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKMYT1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (111 - 357)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 499 a.a.
Protein Preferred Names Protein Names

membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

  • myt1 kinase

PKMYT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PKMYT1 Q99640 CDK1 Homo sapiens P06493
Pull Down
32707033
Intra
PKMYT1 Q99640 CDK1 Homo sapiens P06493
Anti Tag CoIP
35271311
Intra
PKMYT1 Q99640 CCNB1 Homo sapiens P14635
Anti Tag CoIP
10373560
Intra
PKMYT1 Q99640 CCNB1 Homo sapiens P14635
Pull Down
32707033
Intra
PKMYT1 Q99640 CCNB1 Homo sapiens P14635
Anti Tag CoIP
35271311
Intra
PKMYT1 Q99640 CCNB1 Homo sapiens P14635
PLA
23397142
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-145817A lunresertib Inhibitor 99.97% Phase 2

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122113 PD173952 Inhibitor 99.58% Unkown
HY-145817 (Rac)-lunresertib Inhibitor 99.72% Unkown
HY-170517 PKMYT1-IN-8 Inhibitor 99.31% Unkown
HY-145664 Myt1-IN-1 Inhibitor 98.97% Unkown
HY-145666 Myt1-IN-3 Inhibitor 99.14% Unkown
HY-163490 PKMYT1-IN-1 Inhibitor 99.24% Unkown
HY-169946 WEE1/PKMYT1-IN-1 Inhibitor 98.84% Unkown
HY-145817B (R)-lunresertib Inhibitor 99.87% Unkown
HY-180485 PROTAC D16-M1P2 Degrader / Unkown
HY-145665 Myt1-IN-2 Inhibitor / Unkown
HY-172759 PKMYT1-IN-9 Inhibitor / Unkown
HY-182790 BAA-065 Inhibitor / Unkown
HY-175819 PD-166285 Inhibitor / Unkown
HY-169946B WEE1/PKMYT1-IN-3 Inhibitor / Unkown
HY-182791 BAA-009 Inhibitor / Unkown
HY-169946A WEE1/PKMYT1-IN-2 Inhibitor / Unkown
HY-163491 PKMYT1-IN-2 Inhibitor / Unkown
HY-183547 WEE1/PKMYT1-IN-4 Inhibitor / Unkown
HY-180484 PKMYT1-IN-12 Inhibitor / Unkown
HY-180893 XH-30 Inhibitor / Unkown
HY-175817 PKMYT1-IN-10 Inhibitor / Unkown
HY-157443 Myt1-IN-4 Inhibitor / Unkown
HY-162849 PKMYT1-IN-3 Inhibitor / Unkown
HY-162986 PKMYT1-IN-4 Inhibitor / Unkown
HY-162988 Myt1-IN-5 Inhibitor / Unkown
HY-162987 PKMYT1-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PKMYT1 VGNC VGNC:64194
Mus musculus PKMYT1 MGD MGI:2137630
Macaca mulatta PKMYT1 VGNC VGNC:75885
Canis familiaris PKMYT1 VGNC VGNC:44610
Bos taurus PKMYT1 VGNC VGNC:32944
Rattus norvegicus PKMYT1 RGD RGD:1305434
Others PKMYT1 NCBI