MORF4L2 - mortality factor 4 like 2 Gene

Also Known as MRGX; MORFL2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9643

About MORF4L2

Cytogenetic location: Xq22.2 Genomic coordinates (GRCh38): X:103,675,498-103,688,047 (from NCBI)

This gene has 13 transcripts (splice variants), 123 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 110.4), endometrium (RPKM 100.8) and 25 other tissues.

Summary

Predicted to be involved in heterochromatin assembly and histone modification. Predicted to act upstream of or within positive regulation of striated muscle cell differentiation and positive regulation of transcription by RNA polymerase II. Located in nucleolus; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MORF4L2 Products (16)

mRNA Protein Name
NM_001142418.2 NP_001135890.1 mortality factor 4-like protein 2
NM_001142419.2 NP_001135891.1 mortality factor 4-like protein 2
NM_001142420.2 NP_001135892.1 mortality factor 4-like protein 2
NM_001142421.2 NP_001135893.1 mortality factor 4-like protein 2
NM_001142422.2 NP_001135894.1 mortality factor 4-like protein 2
NM_001142423.2 NP_001135895.1 mortality factor 4-like protein 2
NM_001142424.2 NP_001135896.1 mortality factor 4-like protein 2
NM_001142425.2 NP_001135897.1 mortality factor 4-like protein 2
NM_001142426.2 NP_001135898.1 mortality factor 4-like protein 2
NM_001142427.2 NP_001135899.1 mortality factor 4-like protein 2
NM_001142428.2 NP_001135900.1 mortality factor 4-like protein 2
NM_001142429.2 NP_001135901.1 mortality factor 4-like protein 2
NM_001142430.2 NP_001135902.1 mortality factor 4-like protein 2
NM_001142431.2 NP_001135903.1 mortality factor 4-like protein 2
NM_001142432.2 NP_001135904.1 mortality factor 4-like protein 2
NM_012286.3 NP_036418.1 mortality factor 4-like protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11988016 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
27153538 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
27153538 GOA
Cellular Component GO Annotation Evidence References Source
part of NuA4 histone acetyltransferase complex IDA
IDA: Inferred from direct assay
27153538 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
10942595 GOA
part of nucleosome IDA
IDA: Inferred from direct assay
27153538 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MORF4L2 Protein Structure

MRG

MRG: MRG (102 - 276)

  • 0
  • 100
  • 200
  • 288 a.a.
Protein Preferred Names Protein Names

mortality factor 4-like protein 2

  • MORF-related gene X protein

MORF4L2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MORF4L2 Q15014 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra
MORF4L2 Q15014 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra
MORF4L2 Q15014 BEND7 Homo sapiens Q8N7W2-2
Y2H Array
25416956
Intra
MORF4L2 Q15014 BEND7 Homo sapiens Q8N7W2-2
Y2H Prey Pooling
25416956
Intra
MORF4L2 Q15014 BEND7 Homo sapiens Q8N7W2-2
Validated Y2H
25416956
Intra
MORF4L2 Q15014 BCL11A Homo sapiens Q9H165-2
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 BCL11A Homo sapiens Q9H165-2
Validated Y2H
32296183
Intra
MORF4L2 Q15014 BCL11A Homo sapiens Q9H165-2
Y2H Array
32296183
Intra
MORF4L2 Q15014 LUZP4 Homo sapiens Q9P127
Validated Y2H
32296183
Intra
MORF4L2 Q15014 LUZP4 Homo sapiens Q9P127
Y2H Array
32296183
Intra
MORF4L2 Q15014 LUZP4 Homo sapiens Q9P127
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 KLHL3 Homo sapiens Q8N4I8
Validated Y2H
25416956
Intra
MORF4L2 Q15014 ZBTB10 Homo sapiens Q96DT7
Y2H Prey Pooling
25416956
Intra
MORF4L2 Q15014 ZBTB10 Homo sapiens Q96DT7
Validated Y2H
25416956
Intra
MORF4L2 Q15014 BEX5 Homo sapiens Q5H9J7
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 BEX5 Homo sapiens Q5H9J7
Validated Y2H
32296183
Intra
MORF4L2 Q15014 BEX5 Homo sapiens Q5H9J7
Y2H Array
32296183
Intra
MORF4L2 Q15014 TSN Homo sapiens Q15631
Validated Y2H
32296183
Intra
MORF4L2 Q15014 TSN Homo sapiens Q15631
Y2H Array
32296183
Intra
MORF4L2 Q15014 TSN Homo sapiens Q15631
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
MORF4L2 Q15014 CAMK2B Homo sapiens Q13554-3
Y2H Array
32296183
Intra
MORF4L2 Q15014 CAMK2B Homo sapiens Q13554-3
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 CDR2 Homo sapiens Q01850
Y2H
11988016
Intra
MORF4L2 Q15014 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Array
32296183
Intra
MORF4L2 Q15014 L3MBTL3 Homo sapiens Q96JM7-2
Validated Y2H
32296183
Intra
MORF4L2 Q15014 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra
MORF4L2 Q15014 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra
MORF4L2 Q15014 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 ZNF48 Homo sapiens Q96MX3
Y2H Array
32296183
Intra
MORF4L2 Q15014 ZNF48 Homo sapiens Q96MX3
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 ZNF48 Homo sapiens Q96MX3
Validated Y2H
32296183
Intra
MORF4L2 Q15014 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
MORF4L2 Q15014 FBXO16 Homo sapiens Q8IX29
Y2H Array
32296183
Intra
MORF4L2 Q15014 FBXO16 Homo sapiens Q8IX29
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 FBXO16 Homo sapiens Q8IX29
Validated Y2H
32296183
Intra
MORF4L2 Q15014 SYN3 Homo sapiens Q17R54
Validated Y2H
32296183
Intra
MORF4L2 Q15014 SYN3 Homo sapiens Q17R54
Y2H Array
32296183
Intra
MORF4L2 Q15014 SYN3 Homo sapiens Q17R54
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 PIBF1 Homo sapiens Q4G0R1
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 PIBF1 Homo sapiens Q4G0R1
Validated Y2H
32296183
Intra
MORF4L2 Q15014 PIBF1 Homo sapiens Q4G0R1
Y2H Array
32296183
Intra
MORF4L2 Q15014 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
MORF4L2 Q15014 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
MORF4L2 Q15014 GPBP1 Homo sapiens Q86WP2
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 GPBP1 Homo sapiens Q86WP2
Validated Y2H
32296183
Intra
MORF4L2 Q15014 GPBP1 Homo sapiens Q86WP2
Y2H Array
32296183
Intra
MORF4L2 Q15014 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
32296183
Intra
MORF4L2 Q15014 HMBOX1 Homo sapiens Q6NT76
Y2H Array
32296183
Intra
MORF4L2 Q15014 GRAMD2B Homo sapiens Q96HH9
Y2H Prey Pooling
25416956
Intra
MORF4L2 Q15014 GRAMD2B Homo sapiens Q96HH9
Y2H Array
25416956
Intra
MORF4L2 Q15014 GRAMD2B Homo sapiens Q96HH9
Validated Y2H
25416956
Intra
MORF4L2 Q15014 TNIP1 Homo sapiens Q15025
Y2H Array
31515488
Intra
MORF4L2 Q15014 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
25416956
Intra
MORF4L2 Q15014 MRPL12 Homo sapiens P52815
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 MRPL12 Homo sapiens P52815
Y2H Array
32296183
Intra
MORF4L2 Q15014 ZBTB26 Homo sapiens Q9HCK0
Validated Y2H
32296183
Intra
MORF4L2 Q15014 ZBTB26 Homo sapiens Q9HCK0
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 ZBTB26 Homo sapiens Q9HCK0
Y2H Array
32296183
Intra
MORF4L2 Q15014 MRGBP Homo sapiens Q9NV56
Validated Y2H
25416956
Intra
MORF4L2 Q15014 MRGBP Homo sapiens Q9NV56
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 MRGBP Homo sapiens Q9NV56
Validated Y2H
32296183
Intra
MORF4L2 Q15014 MRGBP Homo sapiens Q9NV56
Y2H Array
32296183
Intra
MORF4L2 Q15014 ARID3A Homo sapiens Q99856
Validated Y2H
32296183
Intra
MORF4L2 Q15014 ARID3A Homo sapiens Q99856
Y2H Array
32296183
Intra
MORF4L2 Q15014 ARID3A Homo sapiens Q99856
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
MORF4L2 Q15014 PHC2 Homo sapiens Q8IXK0
Validated Y2H
25416956
Intra
MORF4L2 Q15014 PHC2 Homo sapiens Q8IXK0
Y2H Prey Pooling
25416956
Intra
MORF4L2 Q15014 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra
MORF4L2 Q15014 TLE5 Homo sapiens Q08117
Y2H Array
25416956
Intra
MORF4L2 Q15014 TRIM41 Homo sapiens Q8WV44
Validated Y2H
32296183
Intra
MORF4L2 Q15014 TRIM41 Homo sapiens Q8WV44
Y2H Array
32296183
Intra
MORF4L2 Q15014 TRIM41 Homo sapiens Q8WV44
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 ZBTB7B Homo sapiens O15156
Y2H Prey Pooling
25416956
Intra
MORF4L2 Q15014 ZBTB7B Homo sapiens O15156
Y2H Array
25416956
Intra
MORF4L2 Q15014 ZBTB43 Homo sapiens O43298
Y2H Array
31515488
Intra
MORF4L2 Q15014 ZBTB43 Homo sapiens O43298
Validated Y2H
25416956
Intra
MORF4L2 Q15014 ZBTB43 Homo sapiens O43298
Y2H Prey Pooling
25416956
Intra
MORF4L2 Q15014 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
Intra
MORF4L2 Q15014 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra
MORF4L2 Q15014 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra
MORF4L2 Q15014 THAP1 Homo sapiens Q9NVV9
Validated Y2H
25416956
Intra
MORF4L2 Q15014 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
MORF4L2 Q15014 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 DDIT4L Homo sapiens Q96D03
Validated Y2H
25416956
Intra
MORF4L2 Q15014 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
MORF4L2 Q15014 IKZF1 Homo sapiens Q13422
Y2H Prey Pooling
25416956
Intra
MORF4L2 Q15014 IKZF1 Homo sapiens Q13422
Validated Y2H
25416956
Intra
MORF4L2 Q15014 AMOTL2 Homo sapiens Q9Y2J4
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 AMOTL2 Homo sapiens Q9Y2J4
Validated Y2H
32296183
Intra
MORF4L2 Q15014 AMOTL2 Homo sapiens Q9Y2J4
Y2H Array
32296183
Intra
MORF4L2 Q15014 CEP55 Homo sapiens Q53EZ4
Validated Y2H
32296183
Intra
MORF4L2 Q15014 CEP55 Homo sapiens Q53EZ4
Validated Y2H
25416956
Intra
MORF4L2 Q15014 CEP55 Homo sapiens Q53EZ4
Y2H Array
32296183
Intra
MORF4L2 Q15014 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
25416956
Intra
MORF4L2 Q15014 CEP55 Homo sapiens Q53EZ4
Y2H Array
25416956
Intra
MORF4L2 Q15014 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 MRFAP1L1 Homo sapiens Q96HT8
Validated Y2H
32296183
Intra
MORF4L2 Q15014 MRFAP1L1 Homo sapiens Q96HT8
Y2H Array
32296183
Intra
MORF4L2 Q15014 MRFAP1L1 Homo sapiens Q96HT8
Anti Tag CoIP
28514442
Intra
MORF4L2 Q15014 MRFAP1L1 Homo sapiens Q96HT8
Y2H Prey Pooling
25416956
Intra
MORF4L2 Q15014 MRFAP1L1 Homo sapiens Q96HT8
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
MORF4L2 Q15014 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
MORF4L2 Q15014 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 EVI5 Homo sapiens O60447
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 EVI5 Homo sapiens O60447
Y2H Array
32296183
Intra
MORF4L2 Q15014 NAB2 Homo sapiens Q15742
Validated Y2H
32296183
Intra
MORF4L2 Q15014 NAB2 Homo sapiens Q15742
Y2H Array
32296183
Intra
MORF4L2 Q15014 NAB2 Homo sapiens Q15742
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 KCTD1 Homo sapiens Q719H9
Validated Y2H
32296183
Intra
MORF4L2 Q15014 KCTD1 Homo sapiens Q719H9
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 KCTD1 Homo sapiens Q719H9
Y2H Array
32296183
Intra
MORF4L2 Q15014 EP400P1 Homo sapiens Q6ZTU2
Anti Tag CoIP
33961781
Intra
MORF4L2 Q15014 EP400P1 Homo sapiens Q6ZTU2
Anti Tag CoIP
28514442
Intra
MORF4L2 Q15014 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
25416956
Intra
MORF4L2 Q15014 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
32296183
Intra
MORF4L2 Q15014 MRFAP1 Homo sapiens Q9Y605
Y2H Prey Pooling
32296183
Intra
MORF4L2 Q15014 MRFAP1 Homo sapiens Q9Y605
Y2H Array
32296183
Intra
MORF4L2 Q15014 MRFAP1 Homo sapiens Q9Y605
Anti Tag CoIP
28514442
Intra
MORF4L2 Q15014 MRFAP1 Homo sapiens Q9Y605
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MORF4L2 Proteins

Cat. No. Product Name Accession Purity
HY-P70839 MORF4L2 Protein, Human (His) Q15014 (M1-L288) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Paraneoplastic Cerebellar Degeneration

  • Pcd

  • Paraneoplastic Cerebellar Ataxia

  • Rapidely Progressive Cerebellar Syndrome

  • Subacute Cerebellar Degeneration
Pelizaeus-Merzbacher Disease

  • PMD

  • HLD1

  • Pelizaeus-Merzbacher Brain Sclerosis

  • Leukodystrophy, Hypomyelinating, 1

  • Diffuse Familial Brain Sclerosis

  • Pelizaeus Merzbacher Brain Sclerosis

  • Sudanophilic Leukodystrophy, Paelizeus-Merzbacher Type

  • Cockayne-Pelizaeus-Merzbacher Disease

  • Hypomyelinating Leukodystrophy 1

  • Leukodystrophy, Sudanophilic

  • Pelizaeus Merzbacher Disease

  • Hypomyelinating Leukodystrophy, 1

  • Sudanophilic Leukodystrophy

  • Pelizaeus-Merzbacher Disease, Connatal Form

  • Connatal Pmd

  • Pelizaeus-Merzbacher Disease Type Ii

  • Severe Pmd

  • Null Syndrome

  • Plp1 Null Syndrome

  • Pelizaeus-Merzbacher Disease, Null Syndrome

  • Brain Sclerosis Diffuse Familial

  • Sudanophilic Leukodystrophy Paelizeus-Merzbacher Type

  • Leukodystrophy Hypomyelinating 1

  • Diffuse Cerebral Sclerosis Of Schilder
Hypomyelinating Leukodystrophy

  • Hld

  • Leukodystrophy, Hypomyelinating
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08594 MORF4L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19092 Morf4l2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25582 Morf4l2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MORF4L2 RGD RGD:1359471
Mus musculus MORF4L2 MGD MGI:1927167
Macaca mulatta MORF4L2 VGNC VGNC:103833
Bos taurus MORF4L2 VGNC VGNC:31557
Felis catus MORF4L2 VGNC VGNC:103736
Canis familiaris MORF4L2 VGNC VGNC:43320
Others MORF4L2 NCBI