country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-169014

Copy Link Print Information

HDAC-IN-77

HDAC-IN-77 (HL-5s) is an HDAC inhibitor. HDAC-IN-77 can induce ferroptosis and inhibit the Nrf2/HO-1 signaling pathway. HDAC-IN-77 can be used in cancer research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₂H₂₆N₄O₂S
Molecular Weight:410.53

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

HDAC-IN-77 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

HDAC-IN-77 (HL-5s) is an HDAC inhibitor. HDAC-IN-77 can induce ferroptosis and inhibit the Nrf2/HO-1 signaling pathway. HDAC-IN-77 can be used in cancer research^[1].

Alle HDAC Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.84 μM Compound: HL-5s	Antiproliferative activity against human A549 cells incubated for 24 to 48 hrs by CCK-8 assay Antiproliferative activity against human A549 cells incubated for 24 to 48 hrs by CCK-8 assay	[PMID: 39145486]
HeLa	IC₅₀	1.09 μM Compound: HL-5s	Antiproliferative activity against human HeLa cells incubated for 24 to 48 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells incubated for 24 to 48 hrs by CCK-8 assay	[PMID: 39145486]
Jurkat	IC₅₀	1.54 μM Compound: HL-5s	Antiproliferative activity against human Jurkat cells incubated for 24 to 48 hrs by CCK-8 assay Antiproliferative activity against human Jurkat cells incubated for 24 to 48 hrs by CCK-8 assay	[PMID: 39145486]
MDA-MB-231	IC₅₀	0.9 μM Compound: HL-5s	Antiproliferative activity against human MDA-MB-231 cells incubated for 24 to 48 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-231 cells incubated for 24 to 48 hrs by CCK-8 assay	[PMID: 39145486]
PC-9	IC₅₀	0.18 μM Compound: HL-5s	Antiproliferative activity against human PC-9 cells incubated for 24 to 48 hrs by CCK-8 assay Antiproliferative activity against human PC-9 cells incubated for 24 to 48 hrs by CCK-8 assay	[PMID: 39145486]
THP-1	IC₅₀	0.41 μM Compound: HL-5s	Antiproliferative activity against human THP-1 cells incubated for 24 to 48 hrs by CCK-8 assay Antiproliferative activity against human THP-1 cells incubated for 24 to 48 hrs by CCK-8 assay	[PMID: 39145486]

Chemical Information

Molecular Weight 410.53
Formel C₂₂H₂₆N₄O₂S
SMILES

O=C(/C=C/C1=CC=C(CSC2=NC3=CC=CC=C3N2CCCN(C)C)C=C1)NO
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Liu M, et al. Discovery of a Novel Benzimidazole Derivative Targeting Histone Deacetylase to Induce Ferroptosis and Trigger Immunogenic Cell Death. J Med Chem. 2024 Sep 12;67(17):15098-15117. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen