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Cat. No.: HY-169014

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HDAC-IN-77

HDAC-IN-77 (HL-5s) is an HDAC inhibitor. HDAC-IN-77 can induce ferroptosis and inhibit the Nrf2/HO-1 signaling pathway. HDAC-IN-77 can be used in cancer research.

For research use only. We do not sell to patients.

Formula: C₂₂H₂₆N₄O₂S
Molecular Weight:410.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

HDAC-IN-77 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

HDAC-IN-77 (HL-5s) is an HDAC inhibitor. HDAC-IN-77 can induce ferroptosis and inhibit the Nrf2/HO-1 signaling pathway. HDAC-IN-77 can be used in cancer research^[1].

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.84 μM Compound: HL-5s	Antiproliferative activity against human A549 cells incubated for 24 to 48 hrs by CCK-8 assay Antiproliferative activity against human A549 cells incubated for 24 to 48 hrs by CCK-8 assay	[PMID: 39145486]
HeLa	IC₅₀	1.09 μM Compound: HL-5s	Antiproliferative activity against human HeLa cells incubated for 24 to 48 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells incubated for 24 to 48 hrs by CCK-8 assay	[PMID: 39145486]
Jurkat	IC₅₀	1.54 μM Compound: HL-5s	Antiproliferative activity against human Jurkat cells incubated for 24 to 48 hrs by CCK-8 assay Antiproliferative activity against human Jurkat cells incubated for 24 to 48 hrs by CCK-8 assay	[PMID: 39145486]
MDA-MB-231	IC₅₀	0.9 μM Compound: HL-5s	Antiproliferative activity against human MDA-MB-231 cells incubated for 24 to 48 hrs by CCK-8 assay Antiproliferative activity against human MDA-MB-231 cells incubated for 24 to 48 hrs by CCK-8 assay	[PMID: 39145486]
PC-9	IC₅₀	0.18 μM Compound: HL-5s	Antiproliferative activity against human PC-9 cells incubated for 24 to 48 hrs by CCK-8 assay Antiproliferative activity against human PC-9 cells incubated for 24 to 48 hrs by CCK-8 assay	[PMID: 39145486]
THP-1	IC₅₀	0.41 μM Compound: HL-5s	Antiproliferative activity against human THP-1 cells incubated for 24 to 48 hrs by CCK-8 assay Antiproliferative activity against human THP-1 cells incubated for 24 to 48 hrs by CCK-8 assay	[PMID: 39145486]

Chemical Information

Molecular Weight 410.53
Formula C₂₂H₂₆N₄O₂S
SMILES

O=C(/C=C/C1=CC=C(CSC2=NC3=CC=CC=C3N2CCCN(C)C)C=C1)NO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu M, et al. Discovery of a Novel Benzimidazole Derivative Targeting Histone Deacetylase to Induce Ferroptosis and Trigger Immunogenic Cell Death. J Med Chem. 2024 Sep 12;67(17):15098-15117. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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