HDAC-IN-77
HDAC-IN-77 (HL-5s) is an HDAC inhibitor. HDAC-IN-77 can induce ferroptosis and inhibit the Nrf2/HO-1 signaling pathway. HDAC-IN-77 can be used in cancer research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C22H26N4O2S
- Peso molecular:410.53
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Actividad biológica
Descripciòn
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.84 μM
Compound: HL-5s
|
Antiproliferative activity against human A549 cells incubated for 24 to 48 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells incubated for 24 to 48 hrs by CCK-8 assay
|
[PMID: 39145486] |
| HeLa | IC50 |
1.09 μM
Compound: HL-5s
|
Antiproliferative activity against human HeLa cells incubated for 24 to 48 hrs by CCK-8 assay
Antiproliferative activity against human HeLa cells incubated for 24 to 48 hrs by CCK-8 assay
|
[PMID: 39145486] |
| Jurkat | IC50 |
1.54 μM
Compound: HL-5s
|
Antiproliferative activity against human Jurkat cells incubated for 24 to 48 hrs by CCK-8 assay
Antiproliferative activity against human Jurkat cells incubated for 24 to 48 hrs by CCK-8 assay
|
[PMID: 39145486] |
| MDA-MB-231 | IC50 |
0.9 μM
Compound: HL-5s
|
Antiproliferative activity against human MDA-MB-231 cells incubated for 24 to 48 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 24 to 48 hrs by CCK-8 assay
|
[PMID: 39145486] |
| PC-9 | IC50 |
0.18 μM
Compound: HL-5s
|
Antiproliferative activity against human PC-9 cells incubated for 24 to 48 hrs by CCK-8 assay
Antiproliferative activity against human PC-9 cells incubated for 24 to 48 hrs by CCK-8 assay
|
[PMID: 39145486] |
| THP-1 | IC50 |
0.41 μM
Compound: HL-5s
|
Antiproliferative activity against human THP-1 cells incubated for 24 to 48 hrs by CCK-8 assay
Antiproliferative activity against human THP-1 cells incubated for 24 to 48 hrs by CCK-8 assay
|
[PMID: 39145486] |
Chemical Information
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Peso molecular 410.53
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Fòrmula C22H26N4O2S
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SMILES
O=C(/C=C/C1=CC=C(CSC2=NC3=CC=CC=C3N2CCCN(C)C)C=C1)NO
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)