Hydroxychlorodenafil

Cat. No.: HY-135632 Purity: 99.04%: Data Sheet
COA

SDS
Handling Instructions
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Hydroxychlorodenafil (compound 40) is a phosphodiesterase (PDE) inhibitor. Hydroxychlorodenafil can be used in cancer research.

For research use only. We do not sell to patients.

Hydroxychlorodenafil Chemical Structure

CAS No. : 1391054-00-4

Size	Price	Stock
25 mg		Ask For Quote & Lead Time
50 mg		Ask For Quote & Lead Time

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

Biological Activity
Purity & Documentation
References
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Description

Hydroxychlorodenafil (compound 40) is a phosphodiesterase (PDE) inhibitor. Hydroxychlorodenafil can be used in cancer research^[1].

Molecular Weight

390.86

Formula

C₁₉H₂₃ClN₄O₃

CAS No.

1391054-00-4

Appearance

Solid

Color

White to off-white

SMILES

O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(C(O)CCl)=CC=C3OCC)N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 30 mg/mL (76.75 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5585 mL	12.7923 mL	25.5846 mL
5 mM	0.5117 mL	2.5585 mL	5.1169 mL
10 mM	0.2558 mL	1.2792 mL	2.5585 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.6%

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Data Sheet (268 KB) SDS (251 KB)

COA (249 KB)

Handling Instructions (2659 KB)

References

[1]. Xiang Fei,et al. Use of a composition comprising a heterocyclic compound for the manufacture of a medicament for the treatment of phosphodiesterase mediated diseases. 2020.04.05.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5585 mL	12.7923 mL	25.5846 mL	63.9615 mL
	5 mM	0.5117 mL	2.5585 mL	5.1169 mL	12.7923 mL
	10 mM	0.2558 mL	1.2792 mL	2.5585 mL	6.3962 mL
	15 mM	0.1706 mL	0.8528 mL	1.7056 mL	4.2641 mL
	20 mM	0.1279 mL	0.6396 mL	1.2792 mL	3.1981 mL
	25 mM	0.1023 mL	0.5117 mL	1.0234 mL	2.5585 mL
	30 mM	0.0853 mL	0.4264 mL	0.8528 mL	2.1321 mL
	40 mM	0.0640 mL	0.3198 mL	0.6396 mL	1.5990 mL
	50 mM	0.0512 mL	0.2558 mL	0.5117 mL	1.2792 mL
	60 mM	0.0426 mL	0.2132 mL	0.4264 mL	1.0660 mL