Bryostatin 3
Bryostatin 3, a macrocyclic lactone, is a protein kinase C activator, with a Ki of 2.75 nM. Bryostatin 3 can block 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibition of cell proliferation, yet did not block TPA-enhanced cell-substratum adhesion.
For research use only. We do not sell to patients.
- CAS No.: 143370-84-7
- Formula: C46H64O17
- Molecular Weight:888.99
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ki: 2.75 nM (protein kinase C)[1]
Bryostatin 3 (1 μM; 24 h) does not inhibit [3Hlthymidine incorporation and largely blocks the growth-inhibitory action of TPA[2].
Bryostatin 3 (1 μM; 24 h) blocks the action of TPA to inhibit cell proliferation but does not block TPA-enhanced cell-substratum adhesion[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 143370-84-7
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Molecular Weight 888.99
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Formula C46H64O17
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SMILES
CCC/C=C/C=C/C(O[C@H]1C([C@@](O2)([H])[C@]3([H])O[C@]1(C(C)(/C=C\[C@](C/4)([H])O[C@](CC4=C\C(OC)=O)([H])C[C@@](C(C)([C@@H](OC(C)=O)C[C@@]5([H])C[C@@H](O)CC(OC([C@H](O)C)C3)=O)C)(O5)O)C)O)=CC2=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wender PA, et, al. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7197-201. [Content Brief]
[2]. Mackanos EA, et, al. Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation. J Biol Chem. 1991 Jun 15;266(17):11205-12. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bryostatin 3 Related Classifications
HY-108602 Related Classifications
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