Emilumenib
Based on 1 Customer Validation
Emilumenib (Menin-MLL inhibitor 26) is an orally active Menin-MLL inhibitor. Emilumenib also is an active reference. Emilumenib can inhibits cell growth. Emilumenib can be used for the research of leukemia.
For research use only. We do not sell to patients.
- Purity: 96.22%
- CAS No.: 2440018-29-9
- Formula: C27H29F3N6O3S
- Molecular Weight:574.62
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Emilumenib (0-10 μM, 7 days) inhibits the menin-MLL1 interaction, exhibits cytotoxicity in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) cells, that inhibits the cell growth of MLL or NPM1 mutated MV4-11, MOLM-13, OCI-AML3 and KOPN-8 with GI50s of 2.5, 6.2, 10 and 28.5 nM, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MA9
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Concentration:1.5-41 nM
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Incubation Time:4 days
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Result:Inhibited the expression of Meis1, Hoxa9, Mef2c and Pbx3.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MOLM-13 xenograft mouse model[2]
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Dosage:25-200 mg/kg
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Administration:po for 17 days
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Result:Reduced the CD45 positive cells, prolonged the survival time.
Chemical Information
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CAS No. 2440018-29-9
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Appearance Solid
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Molecular Weight 574.62
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Formula C27H29F3N6O3S
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Color White to off-white
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SMILES
CN([C@H]1C[C@H](C[C@H]1O)NCC2=CC=C(C3=CC(OC)=C(N=N3)OC)C=C2)C4=C5C(SC(CC(F)(F)F)=C5)=NC=N4
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Synonyms
DS-1594a; Menin-MLL inhibitor 26
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 41.67 mg/mL (72.52 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7403 mL | 8.7014 mL | 17.4028 mL | 43.5070 mL |
| 5 mM | 0.3481 mL | 1.7403 mL | 3.4806 mL | 8.7014 mL | |
| 10 mM | 0.1740 mL | 0.8701 mL | 1.7403 mL | 4.3507 mL | |
| 15 mM | 0.1160 mL | 0.5801 mL | 1.1602 mL | 2.9005 mL | |
| 20 mM | 0.0870 mL | 0.4351 mL | 0.8701 mL | 2.1754 mL | |
| 25 mM | 0.0696 mL | 0.3481 mL | 0.6961 mL | 1.7403 mL | |
| 30 mM | 0.0580 mL | 0.2900 mL | 0.5801 mL | 1.4502 mL | |
| 40 mM | 0.0435 mL | 0.2175 mL | 0.4351 mL | 1.0877 mL | |
| 50 mM | 0.0348 mL | 0.1740 mL | 0.3481 mL | 0.8701 mL | |
| 60 mM | 0.0290 mL | 0.1450 mL | 0.2900 mL | 0.7251 mL |
Emilumenib Related Classifications
HY-148676 Related Classifications
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