GRWD5769
GRWD5769 is an orally potent ERAP1 inhibitor. GRWD5769 regulates the peptide repertoire presented by MHC-I, alters TCR diversity/clonality, reprograms antigen-experienced T cells, induces novel T cell responses, drives tumor cell killing, and alleviates T cell exhaustion. GRWD5769 can be used in the research of advanced solid malignancies, microsatellite-stable colorectal cancer, non-small cell lung cancer, bladder cancer, hepatocellular carcinoma, head and neck squamous cell carcinoma, and cervical cancer.
For research use only. We do not sell to patients.
- CAS No.: 2420554-24-9
- Formula: C22H22ClN3O4S
- Molecular Weight:459.95
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
MHC I |
ERAP1 |
Combination treatment with GRWD5769 and anti-PD-1 mAb (HY-P99144) increases intratumoral TCR repertoire diversity, promotes T cell infiltration, upregulates markers associated with immune responses as well as recently activated, non-exhausted T cells, and inhibits tumor growth across multiple syngeneic tumor models in different mouse strains.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2420554-24-9
-
Molecular Weight 459.95
-
Formula C22H22ClN3O4S
-
SMILES
ClC(C=C1N2CCCCC2)=C(C#N)C=C1NS(C3=CC(C(O)=O)=CC=C3C4CC4)(=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GRWD5769 Related Classifications
HY-184499 Related Classifications
Powered by Bioz