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Cat. No.: HY-151259

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TK4b

TK4b is a dual JAK2/3 inhibitor with human JAK2 and JAK3 IC₅₀s of 19.40 nM and 18.42 nM, respectively. TK4b can be used for the research of leukemia and myelofibrosis.

For research use only. We do not sell to patients.

CAS No.: 2232890-81-0
Formula: C₂₁H₂₂N₂O₂
Molecular Weight:334.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

TK4b Chemical Structure

CAS No.: 2232890-81-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

TK4b is a dual JAK2/3 inhibitor with human JAK2 and JAK3 IC₅₀s of 19.40 nM and 18.42 nM, respectively. TK4b can be used for the research of leukemia and myelofibrosis^[1].

IC₅₀ & Target^[1]

JAK2

19.40 nM (IC₅₀)

JAK3

18.42 nM (IC₅₀)

All JAK Isoforms :

In Vitro

TK4b (1 μM; 1 h) potently inhibits purified JAK2 with an IC₅₀ of 19.40 nM and purified JAK3 with an IC₅₀ of 18.42 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2232890-81-0
Molecular Weight 334.41
Formula C₂₁H₂₂N₂O₂
SMILES

O=C1N(C2=CC=C(C)C(C)=C2)N(CC)C(C)=C1C(C3=CC=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sanachai K, et al. Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases. ACS Omega. 2022;7(37):33548-33559. Published 2022 Sep 6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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TK4b

All JAK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TK4b Related Classifications

HY-151259 Related Classifications