Y11
Based on 1 Customer Validation
Y11 inhibits the autophosphorylation of FAK1 by blocking the phosphorylation of Y397. Y11 increases the expression level of IL-6. Y11 is applicable for cancer research.
For research use only. We do not sell to patients.
- Purity: 98.34%
- CAS No.: 1086639-59-9
- Formula: C8H17BrN4O
- Molecular Weight:265.15
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Immunology/Inflammation Compound Library
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Protein Tyrosine Kinase Compound Library
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Biological Activity
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IL-6 |
Chemical Information
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CAS No. 1086639-59-9
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Appearance Solid
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Molecular Weight 265.15
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Formula C8H17BrN4O
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Color White to off-white
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SMILES
OCC[N+]12C[N@](C3)C[N@](C[N@]3C2)C1.[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 10 mg/mL (37.71 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Golubovskaya VM, et al. A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. J Med Chem. 2008;51(23):7405-7416. [Content Brief]
[2]. Keasey MP, et al. Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling. J Cell Sci. 2018;131(3):jcs202580. Published 2018 Feb 2. [Content Brief]
[3]. Roux-Osovitz MM, et al. Trapping, tagging and tracking: Tools for the study of proteins during early development of the sea urchin. Methods Cell Biol. 2019;151:283-304. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7715 mL | 18.8573 mL | 37.7145 mL | 94.2863 mL |
| 5 mM | 0.7543 mL | 3.7715 mL | 7.5429 mL | 18.8573 mL | |
| 10 mM | 0.3771 mL | 1.8857 mL | 3.7715 mL | 9.4286 mL | |
| 15 mM | 0.2514 mL | 1.2572 mL | 2.5143 mL | 6.2858 mL | |
| 20 mM | 0.1886 mL | 0.9429 mL | 1.8857 mL | 4.7143 mL | |
| 25 mM | 0.1509 mL | 0.7543 mL | 1.5086 mL | 3.7715 mL | |
| 30 mM | 0.1257 mL | 0.6286 mL | 1.2572 mL | 3.1429 mL |
Y11 Related Classifications
HY-103471 Related Classifications
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