RO5234444
RO5234444 is an orally active CCR2 antagonist, with IC50s of 22nM for human CCR2 and 161 nM for mouse CCR2. RO5234444 alleviates glomerulosclerosis, reduces albuminuria, and significantly improves the glomerular filtration rate (GFR) in the uninephrectomized (1K) type 2 diabetic db/db mouse model. RO5234444 can be used for the study of type 2 diabetic nephropathy.
For research use only. We do not sell to patients.
- CAS No.: 1365266-79-0
- Formula: C24H31ClFN3O3
- Molecular Weight:463.97
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Human CCR2 22 nM (IC50) |
Mouse CCR2 161 nM (IC50) |
Chemical Information
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CAS No. 1365266-79-0
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Molecular Weight 463.97
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Formula C24H31ClFN3O3
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SMILES
O=C1N(CCCN(CC2)C[C@@H](O)C32CC3)CCN(C(/C=C/C4=CC=C(F)C(Cl)=C4)=O)[C@H]1C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RO5234444 Related Classifications
HY-100819 Related Classifications
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