Cat. No.: HY-W051612

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DL-Propargylglycine hydrochloride

Name: DL-Propargylglycine hydrochloride
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SKU: HY-W051612
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2 Cited Publications

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Based on 2 publication(s) in Google Scholar

DL-Propargylglycine hydrochloride is an irreversible and selective CSE inhibitor that blocks the biosynthesis of endogenous hydrogen sulfide. DL-Propargylglycine hydrochloride induces ROS and TGF-β1 expression. DL-Propargylglycine hydrochloride downregulates carotid ACE2 and Ang-(1-7), and elevates Ang II. DL-Propargylglycine hydrochloride upregulates ICAM-1/LFA-1, exacerbating Aspirin (HY-14654)-induced gastric mucosal injury. DL-Propargylglycine hydrochloride is used in research on diabetes-induced liver injury, diabetic nephropathy, atherosclerosis, gastric mucosal injury, hemorrhagic shock, and Streptococcus agalactiae infection.

For research use only. We do not sell to patients.

CAS No.: 16900-57-5
Formula: C₅H₈ClNO₂
Molecular Weight:149.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DL-Propargylglycine hydrochloride Chemical Structure

CAS No.: 16900-57-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[2]

ACE2

All TGF-β Receptor Isoforms :

All Integrin Isoforms :

In Vitro

DL-Propargylglycine (48 h) hydrochloride significantly increases the proliferation of HBZY-1 rat mesangial cells, mimicking the effect of high glucose^[2].
DL-Propargylglycine hydrochloride significantly increases TGF-β1 mRNA levels in HBZY-1 rat mesangial cells^[2].
DL-Propargylglycine (0.3 mM; 12 h) hydrochloride attenuates melatonin-induced improvement of growth and photosynthetic parameters in Triticum aestivum L. cv. Pandas under drought stress^[4].
DL-Propargylglycine (0.3 mM; 12 h) hydrochloride attenuates the melatonin-induced improvement of relative water content and soluble protein levels in Triticum aestivum L. cv. Pandas under drought stress^[4].
DL-Propargylglycine (0.3 mM; 12 h) hydrochloride inhibits L-DES activity and reduces endogenous H₂S levels in Triticum aestivum L. cv. Pandas under drought stress^[4].
DL-Propargylglycine (0.3 mM; 12 h) hydrochloride reduces melatonin-induced improvement of glyoxalase system activity in Triticum aestivum L. cv. Pandas under drought stress^[4].
DL-Propargylglycine (2 mM; 5 min) hydrochloride inhibits H₂S production in rat gastric mucosal homogenates^[5].
DL-Propargylglycine hydrochloride slightly increases PFK activity in AR-GBS^[8].
DL-Propargylglycine hydrochloride enhances ROS generation in HBZY-1 rat mesangial cells, mimicking the effects of high glucose^[2].
DL-Propargylglycine (0.3 mM; 12 h) hydrochloride attenuates the melatonin-induced reduction of oxidative stress markers in Triticum aestivum L. cv. Pandas under drought stress^[4].
DL-Propargylglycine (0.3 mM; 12 h) hydrochloride reduces melatonin-induced enhancement of antioxidant enzyme activity in Triticum aestivum L. cv. Pandas under drought stress^[4].
DL-Propargylglycine hydrochloride alters bacterial metabolism and cell wall/membrane structure in Streptococcus agalactiae^[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DL-propargylglycine (10 mg/kg/day; i.p.; daily; 4 weeks) hydrochloride blocks H₂S generation in mice, which aggravates atherosclerotic plaque burden by inhibiting carotid ACE2 expression^[3].
DL-Propargylglycine (30 mg/kg; injection; single dose) hydrochloride exerts limited synergistic effects in the AR-GBS-infected zebrafish model^[8].
DL-Propargylglycine (25 mg/kg; intravenous injection; single injection; 15 min after morphine) hydrochloride enhances the ability of L-CYSee to overcome morphine-induced ventilatory depression, in which the effects of the first dose of L-CYSee on TV, MV, EEP, PIF, PEF, EF₅₀, and ExpD are enhanced, and the effects of the second dose of L-CYSee on Freq, TV, MV, PIF, PEF, EF₅₀, InspD, and ExpD are more significantly enhanced^[9].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J male apoE−/− (8 weeks old)^[3]
Dosage:

10 mg/kg/day
Administration:

i.p.; daily; 4 weeks
Result:

Induced advanced atherosclerosis with more severe neointimal hyperplasia and more obvious narrowness in LCA.
Enhanced hyperplasia of collagen fibers in neointimal lesions.
Had negligible effect on body weight, plasma lipid profiles, and blood pressure.
Inhibited the expression of ACE2 in endothelial cells in atherosclerotic lesions.
Downregulated carotid ACE2 expression.
Inhibited the local production of Ang-(1-7) in LCA and raised the carotid level of Ang II.

Animal Model:

Zebrafish (average length 2.5-3 cm, average weight 0.2 g)^[8]
Dosage:

30 mg/kg
Administration:

single dose; 1 hour post-infection
Result:

Induced 80% mortality rate in combination with ampicillin.
Did not enhance efficacy when bacteria were pretreated for 6 h prior to infection.

Animal Model:

Sprague Dawley (adult male, 395-396 g body weight)^[9]
Dosage:

25 mg/kg
Administration:

i.v.; single injection; 15 min after morphine
Result:

Augmented L-CYSee-induced changes in TV, MV, EEP, PIF, PEF, EF50, and ExpD after the first L-CYSee dose.
More markedly augmented L-CYSee-induced changes in Freq, TV, MV, PIF, PEF, EF50, InspD, and ExpD after the second L-CYSee dose.
Increased changes in TV, MV, PIF, PEF, inspiratory drive, and expiratory drive during hypoxic-hypercapnic gas challenge.
Increased changes in TV, MV, PIF, PEF, EF50, inspiratory drive, and expiratory drive upon return to room-air.
Did not produce an increase in EEP upon return to room-air, unlike vehicle-treated rats.
Total morphine-induced changes from baseline were similar to vehicle-treated rats, including TV (-13%), MV (-16%), Ti (+43%), EIP (+109%), PIF (-25%), EF50 (+62%), relaxation time (-29%), apneic pause (+29%), inspiratory drive (-40%), and NEBI (-54%).

Chemical Information

CAS No. 16900-57-5
Molecular Weight 149.58
Formula C₅H₈ClNO₂
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Cell Death Dis

Selenomethionine as a dual-mechanism ferroptosis inhibitor: selenium-supply-driven GPX4 biosynthesis beyond transsulfuration and reductive-capacity-mediated ROS scavenging independent of GPX4 activity. [Abstract]

2026 Feb 14;17(1):224. PMID: 41688429
Ind Crops Prod

2026 Feb 12.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dugbartey GJ, et al. Targeting hepatic sulfane sulfur/hydrogen sulfide signaling pathway with α-lipoic acid to prevent diabetes-induced liver injury via upregulating hepatic CSE/3-MST expression. Diabetology & metabolic syndrome. 2022 Oct 13;14(1):148.

[2]. Yuan P, et al. Rescue of mesangial cells from high glucose-induced over-proliferation and extracellular matrix secretion by hydrogen sulfide. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2011 Jul;26(7):2119-26.

[3]. Lin Y, et al. Hydrogen Sulfide Attenuates Atherosclerosis in a Partially Ligated Carotid Artery Mouse model via Regulating Angiotensin Converting Enzyme 2 Expression. Frontiers in physiology. 2017;8:782.

[4]. Muslemyar QS, et al. Melatonin and L‐cysteine desulfhydrase: unraveling hydrogen sulfide signaling for drought tolerance in bread wheat (Triticum aestivum). Food and Energy Security. 2025 May;14(3):e70103.

[5]. Fiorucci S, et al. Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs. Gastroenterology. 2005 Oct;129(4):1210-24.

[6]. Xu Y, et al. Statins upregulate cystathionine γ-lyase transcription and H2S generation via activating Akt signaling in macrophage. Pharmacological research. 2014 Sep;87:18-25.

[7]. Mok YY, et al. Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis. British journal of pharmacology. 2004 Dec;143(7):881-9.

[8]. Chen XW, et al. DL-propargylglycine reverses beta-lactam resistance in Streptococcus agalactiae. Microbiological research. 2026 Jan;302:128350. [Content Brief]

[9]. Getsy PM, et al. The cystathionine-γ-lyase inhibitor DL-propargylglycine augments the ability of L-cysteine ethyl ester to overcome the adverse effects of morphine on breathing. American journal of physiology. Lung cellular and molecular physiology. 2025 Jun 01;328(6):L809-L825.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

DL-Propargylglycine hydrochloride

2 Cited Publications

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DL-Propargylglycine hydrochloride

Publications Citing Use of MedChemExpress (MCE) DL-Propargylglycine hydrochloride

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