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Duvakitug

(Synonyms: TEV-48574; SAR-447189; TEV-574)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Duvakitug (TEV-48574) is a humanized IgG1-λ2 monoclonal antibody targeting to TNFSF15/TL1A. Duvakitug' main expression system is CHOK1SV cells endogenously expressing glutamine synthetase (GS). Duvakitug can be used in the study of Crohn's Disease (CD).

For research use only. We do not sell to patients.

  • Purity: 99.76%
  • CAS No.: 2750005-84-4
  • Molecular Weight:143.64 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Duvakitug
  • Experimental Validation Results for Duvakitug
  • Experimental Validation Results for Duvakitug
  • Experimental Validation Results for Duvakitug
  • Duvakitug Chemical Structure
    Duvakitug Chemical Structure
CAS No.: 2750005-84-4
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Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Duvakitug Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 lambda

  • 1/16

    Immobilized TL1A/TNFSF15 Protein, Human can bind Duvakitug. The EC50 for this effect is 31.43 ng/mL.

  • 1/16

    Loaded TL1A/TNFSF15 Protein, Human (161a.a, HEK293, His, HY-P78447A) on AHC2 biosensor, can bind Duvakitug with an affinity constant of 4.777E-10 M as determined in BLI assay.

  • 1/16

    Flow cytometric analysis of 1×106 MCF-7 cells labelling TL1A (red) with Duvakitug (HY-P990006). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda2 Isotype Control (HY-P990096, blue) was used as the isotype control.

  • Duvakitug Chemical Structure
    1/16
  • Duvakitug
  • Immobilized TL1A/TNFSF15 Protein, Human can bind Duvakitug. The EC50 for this effect is 31.43 ng/mL.
  • Loaded TL1A/TNFSF15 Protein, Human (161a.a, HEK293, His, HY-P78447A) on AHC2 biosensor, can bind Duvakitug with an affinity constant of 4.777E-10 M as determined in BLI assay.
  • Flow cytometric analysis of 1×106 MCF-7 cells labelling TL1A (red) with Duvakitug (HY-P990006). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda2 Isotype Control (HY-P990096, blue) was used as the isotype control.