10-Nitrocamptothecin
10-Nitrocamptothecin is a topoisomerase I inhibitor with an IC50 of 0.64 μM. 10-Nitrocamptothecin interferes with the formation of cleavable complexes, thereby inhibiting the activity of Topoisomerase I. 10-Nitrocamptothecin is applicable for cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 86639-62-5
- 分子式: C20H15N3O6
- 分子量:393.35
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Topoisomerase アイソフォーム固有の製品をすべて表示
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生物活性
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Topoisomerase I 0.64 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| HL-60 | IC50 |
0.64 μM
Compound: 5e
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Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells
Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells
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[PMID: 8410981] |
10-Nitrocamptothecin (Compound 5e) (30 min) inhibits purified calf thymus topoisomerase I by forming a cleavable complex, with an IC50 of 0.64 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 86639-62-5
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分子量 393.35
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分子式 C20H15N3O6
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SMILES
O=C1N2C(C(C(C2)=CC3=C4)=NC3=CC=C4[N+]([O-])=O)=CC5=C1COC([C@]5(O)CC)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
10-Nitrocamptothecin 関連分類
HY-N2062 関連分類
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