7-Hydroxyisoflavone
Based on 1 Customer Validation
7-Hydroxyisoflavone is an enterovirus replication inhibitor. 7-Hydroxyisoflavone inhibits enterovirus 71 viral RNA synthesis, viral protein synthesis, and early replication steps. 7-Hydroxyisoflavone also inhibits coxsackievirus replication. 7-Hydroxyisoflavone enhances AMPK activity and prevents serum-induced reduction of AMPK phosphorylation. 7-Hydroxyisoflavone can be used in research related to enterovirus infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.75%
- CAS 番号: 13057-72-2
- 分子式: C15H10O3
- 分子量:238.24
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保管条件:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
87.03 μM
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Cytotoxicity against African green monkey Vero cells assessed as 50% inhibition of cellular growth after 3 days incubation by Reed and Muench method.
Cytotoxicity against African green monkey Vero cells assessed as 50% inhibition of cellular growth after 3 days incubation by Reed and Muench method.
|
23464760 |
体外実験
7-Hydroxyisoflavone (1.05-8.39 μM; 24 h) inhibits EV71 (SHZH98) viral RNA synthesis in Vero cells in a dose-dependent manner[1].
7-Hydroxyisoflavone (1.05-16.79 μM; 24 h) reduces EV71 (SHZH98) VP1 protein synthesis in Vero cells in a dose-dependent manner[1].
7-Hydroxyisoflavone (3.11 μM; 0-6 h) acts on the early steps of EV71 (SHZH98) replication in Vero cells and exhibits significant antiviral activity[1].
7-Hydroxyisoflavone (48 h) inhibits coxsackieviruses B2, B3, and B6 in Vero cells, with IC50 values of 13.94, 17.04, and 10.03 μM[1].
7-Hydroxyisoflavone (40 μM) activates AMPK in a cell-free AMPK α1β1γ1 kinase assay, producing 108% relative AMPK activity[2].
7-Hydroxyisoflavone (40 μM; 30 min) activates AMPK in 3T3L1 preadipocytes by preventing the reduction of 10% fetal bovine serum-induced AMPK Thr172 phosphorylation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero cells infected with EV71 (SHZH98)
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Concentration:1.05, 2.1, 4.2 and 8.39 μM
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Incubation Time:24 h
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Result:Inhibited EV71 viral RNA synthesis in a dose-dependent manner.
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Cell Line:Vero cells
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Concentration:1.05, 4.2 and 16.79 μM
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Incubation Time:24 h
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Result:Reduced EV71 (SHZH98) VP1 protein synthesis in a dose-dependent manner.
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Cell Line:mouse 3T3L1 preadipocytes
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Concentration:40 μM
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Incubation Time:30 min
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Result:Serum starvation for 24 h increased AMPK phosphorylation at Thr172.
Incubation with 10% fetal bovine serum substantially reduced this serum-starvation-induced increase.
When serum-starved cells received 10% fetal bovine serum in the presence of this compound (40 μM), the serum-induced decrease in AMPK phosphorylation was prevented.
化学情報
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CAS 番号 13057-72-2
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性状 Solid
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分子量 238.24
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分子式 C15H10O3
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Color White to off-white
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SMILES
O=C1C(C2=CC=CC=C2)=COC3=C1C=CC(O)=C3
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Structure Classification
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (209.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (394 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1974 mL | 20.9872 mL | 41.9745 mL | 104.9362 mL |
| 5 mM | 0.8395 mL | 4.1974 mL | 8.3949 mL | 20.9872 mL | |
| 10 mM | 0.4197 mL | 2.0987 mL | 4.1974 mL | 10.4936 mL | |
| 15 mM | 0.2798 mL | 1.3991 mL | 2.7983 mL | 6.9957 mL | |
| 20 mM | 0.2099 mL | 1.0494 mL | 2.0987 mL | 5.2468 mL | |
| 25 mM | 0.1679 mL | 0.8395 mL | 1.6790 mL | 4.1974 mL | |
| 30 mM | 0.1399 mL | 0.6996 mL | 1.3991 mL | 3.4979 mL | |
| 40 mM | 0.1049 mL | 0.5247 mL | 1.0494 mL | 2.6234 mL | |
| 50 mM | 0.0839 mL | 0.4197 mL | 0.8395 mL | 2.0987 mL | |
| 60 mM | 0.0700 mL | 0.3498 mL | 0.6996 mL | 1.7489 mL | |
| 80 mM | 0.0525 mL | 0.2623 mL | 0.5247 mL | 1.3117 mL | |
| 100 mM | 0.0420 mL | 0.2099 mL | 0.4197 mL | 1.0494 mL |
7-Hydroxyisoflavone 関連分類
HY-W031126 関連分類
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