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9-ING-41

(別名: Elraglusib)
6 Cited Publications
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Based on 6 publication(s) in Google Scholar

9-ING-41 (Elraglusib) is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic agents.

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  • 純度: 99.13%
  • CAS 番号: 1034895-42-5
  • 分子式: C22H13FN2O5
  • 分子量:404.35
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • 9-ING-41 Chemical Structure
    9-ING-41 構造式
  • Experimental Validation Results for 9-ING-41
  • Experimental Validation Results for 9-ING-41
  • Experimental Validation Results for 9-ING-41
  • Experimental Validation Results for 9-ING-41
  • Experimental Validation Results for 9-ING-41
CAS 番号: 1034895-42-5
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  • 9-ING-41 Chemical Structure
    9-ING-41 Chemical Structure
    1/16
  • 1/16

    9-ING-41 purchased from MedChemExpress. Usage Cited in: Nature. 2025 Jun;642(8067):508-518. [Abstract]

    Customer Validation
     Analysis of cell viability in THP-1 cells treated with the indicated inhibitors for 5 days by the Cell-Titer-Glo assay.

  • 1/16

    9-ING-41 purchased from MedChemExpress. Usage Cited in: Nature. 2025 Jun;642(8067):508-518. [Abstract]

    Customer Validation
     Wright-Giemsa-stained cytospins for a DNMT3A-mutant primary AML sample treated with DMSO, IMG-7289 (50 nM), 9-ING-41 (100 nM) and combination of both inhibitors.

  • 1/16

    9-ING-41 purchased from MedChemExpress. Usage Cited in: Front Immunol. 2024 May 15:15:1360436. [Abstract]

    Customer Validation
     Bladder cancer cells (MB49) and normal cells (NIH3T3) were treated with 0–10 μM of 9-ING-41 for 48 h The cell viability was determined by MTT assay.

  • 1/16

    9-ING-41 purchased from MedChemExpress. Usage Cited in: Front Immunol. 2024 May 15:15:1360436. [Abstract]

    Customer Validation
     MB49 tumor tissues of mice treated with PBS, 9-ING-41 (10 mg/kg), HY-oAd, and HY-oAd+9-ING-41 were stained with Masson’s trichrome to assess collagen accumulation in the tumor tissues.

  • 1/16

    9-ING-41 purchased from MedChemExpress. Usage Cited in: Front Immunol. 2024 May 15:15:1360436. [Abstract]

    Customer Validation
     Immunohistochemical staining of CD4+ and CD8+ T cells from subcutaneous MB49 tumor tissue sections obtained after treatment with PBS, 9-ING-41 (10 mg/kg), HY-oAd, and HY-oAd+9-ING-41.

  • 9-ING-41