製品番号: HY-B0504

クレアチニ

(別名: Creatinine; NSC13123)

6 Cited Publications

カスタマーレビュー

Based on 6 publication(s) in Google Scholar

Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.92%
CAS 番号: 60-27-5
分子式: C₄H₇N₃O
分子量:113.12

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Creatinine 構造式

CAS 番号: 60-27-5

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数量

Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
- 臨床実験
化学情報
Publications (6)
溶剤 & 溶解度
- 体外
- 体内
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

NMDA Receptor

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

iGluR アイソフォーム固有の製品をすべて表示 :

体外実験

Creatinine (20-180 μM; 24 h) induces a hypermetabolic state in primary inguinal and epididymal adipocytes by activating the futile creatine cycle. 20 μM Creatinine activates inguinal adipocytes, while 180 μM Creatinine activates both inguinal and epididymal adipocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Creatinine (0.1 g/kg; i.p.; daily; 7 d) exacerbates adipose tissue wasting in mice with Unilateral Ureteral Obstruction (UUO)- or renal Ischemia-Reperfusion Injury (IRI)-induced chronic kidney disease (CKD) by increasing creatine accumulation and activating pathways associated with the futile creatine cycle^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 wild type mouse with Chronic kidney disease (male, 8 weeks old, unilateral ureteral obstruction model)^[1]
Dosage:

0.1 g/kg
Administration:

i.p.; daily; 7 days
Result:

Enhanced loss of inguinal (subcutaneous) and epididymal (visceral) adipose tissues relative to UUO-only mice; increased creatine levels in both subcutaneous and visceral adipose tissues; increased the proportion of multilocular adipocytes in both subcutaneous and visceral adipose tissues; upregulated expression of Prdm16, Pgc1α, CKB, Alpl, and Cox7a genes in subcutaneous and visceral adipose tissues

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 60-27-5
性状 Solid
分子量 113.12
分子式 C₄H₇N₃O
Color White to off-white
SMILES

O=C1N=C(N)N(C)C1
別名

Creatinine; NSC13123
Structure Classification
- Others
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (6)

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Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Biomed Pharmacother

Pharmacokinetic profiling of ZCL-278, a cdc42 inhibitor, and its effectiveness against chronic kidney disease. [Abstract]

2024 Aug 23:179:117329. PMID: 39180793
Emerg Contam

2024 Dec, 10, 4, 100351.
Appl Surf Sci

2018 Nov 1, 457:684-694.
J Chromatogr B Analyt Technol Biomed Life Sci

Simultaneous determination of choline, L-carnitine, betaine, trimethylamine, trimethylamine N-oxide, and creatinine in plasma, liver, and feces of hyperlipidemic rats by UHPLC-MS/MS. [Abstract]

2024 Jun 25:1243:124210. PMID: 38936270
Research Square Preprint

2021 Aug.

溶剤 & 溶解度

体外:

H₂O : 33.33 mg/mL (294.64 mM; Need ultrasonic)

DMSO : 2.5 mg/mL (22.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

8.8402 mL

44.2008 mL

88.4017 mL

5 mM

1.7680 mL

8.8402 mL

17.6803 mL

10 mM

0.8840 mL

4.4201 mL

8.8402 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 33.33 mg/mL (294.64 mM); Clear solution; Need ultrasonic

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (275 KB)
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- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Fang J, et al. Creatinine promotes adipose tissue wasting in chronic kidney disease via creatine and futile creatine cycle. Mol Metab. 2025;98:102191. [Content Brief]

[2]. Allen PJ, et al. Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value?. Neurosci Biobehav Rev. 2012;36(5):1442-1462. [Content Brief]

[3]. Polacheck I, et al. Creatinine metabolism in Cryptococcus neoformans and Cryptococcus bacillisporus. J Bacteriol. 1980;142(1):15-20. [Content Brief]

[4]. Zhang H, et al. Boron nitride/gold nanocomposites for crystal violet and creatinine detection by surface-enhanced Raman spectroscopy[J]. Applied Surface Science, 2018, 457: 684-694.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	8.8402 mL	44.2008 mL	88.4017 mL	221.0042 mL
	5 mM	1.7680 mL	8.8402 mL	17.6803 mL	44.2008 mL
	10 mM	0.8840 mL	4.4201 mL	8.8402 mL	22.1004 mL
	15 mM	0.5893 mL	2.9467 mL	5.8934 mL	14.7336 mL
	20 mM	0.4420 mL	2.2100 mL	4.4201 mL	11.0502 mL
H₂O	25 mM	0.3536 mL	1.7680 mL	3.5361 mL	8.8402 mL
	30 mM	0.2947 mL	1.4734 mL	2.9467 mL	7.3668 mL
	40 mM	0.2210 mL	1.1050 mL	2.2100 mL	5.5251 mL
	50 mM	0.1768 mL	0.8840 mL	1.7680 mL	4.4201 mL
	60 mM	0.1473 mL	0.7367 mL	1.4734 mL	3.6834 mL
	80 mM	0.1105 mL	0.5525 mL	1.1050 mL	2.7626 mL
	100 mM	0.0884 mL	0.4420 mL	0.8840 mL	2.2100 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Creatinine

6 Cited Publications

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MedChemExpress（MCE）の使用を引用している文献 Creatinine

Endogenous Metabolite アイソフォーム固有の製品をすべて表示

iGluR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (6)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Creatinine 関連分類

HY-B0504 関連分類