Heparin
Based on 15 publication(s) in Google Scholar
Heparin is a highly sulfated glycosaminoglycan,that is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. Heparin significantly inhibits exosome-cell interactions.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 9005-49-6
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
MedChemExpress(MCE)の使用を引用している文献 Heparin
More- Nat Immunol. 2025 Oct;26(10):1660-1672. [Abstract]
- Nat Commun. 2026 Sep 17;17(1):10907.
- Nat Commun. 2026 Feb 28;17(1):3324. [Abstract]
- Redox Biol. 2025 Sep 22:87:103877. [Abstract]
- Chem Eng J. 2026 Sep 25;549:182363.
- Small. 2026 Sep 21:e75914.
- Phytomedicine. 2026 Jul:156:158184. [Abstract]
- Mol Med. 2025 Aug 16;31(1):278. [Abstract]
- Pharmaceutics. 2025 Nov 27;17(12):1524. [Abstract]
- EMBO Rep. 2025 Sep 15. [Abstract]
- J Thromb Haemost. 2026 Sep;24(9):3213-3223.
- iScience. 2025 Oct 6;28(11):113718. [Abstract]
- Tissue Cell. 2025 Dec:97:103094. [Abstract]
- Anal Cell Pathol. 2026;2026(1):e2525721.
- J Thromb Thrombolysis. 2026 Jul 28.
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ELISA
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ELISA
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Bio/Physico-chemical Assay
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Cell Imaging/Staining
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Cell Imaging/Staining
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
More
生物活性
製品説明
IC50 & Target
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Human Endogenous Metabolite |
体外実験
Heparin (6 days) reduces the cytopathogenicity of HIV for MT-4 cells, with an IC50 of 7.5 μg/mL[2].
Heparin (0.5 U/mL, 48 h) inhibits HGF-induced trophoblast invasion in the SGHPL-4 cell line[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
化学情報
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CAS 番号 9005-49-6
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性状 Solid
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Color White to off-white
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SMILES
O[C@H]1[C@H](O[C@H]2[C@H](OS(O)(=O)=O)[C@@H](O)[C@H](OC)[C@H](C(O)=O)O2)[C@@H](COS(O)(=O)=O)O[C@H](OC)[C@@H]1NS(O)(=O)=O.[n]
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (15)
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Journal Impact Factor
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Most Recent
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Nat Immunol
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response. [Abstract]2025 Oct;26(10):1660-1672. PMID: 40954252 -
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Nat Commun
Targeting leucine-rich repeat kinase 2 overcomes resistance to oncolytic herpes simplex virus-based therapies in glioblastoma. [Abstract]2026 Feb 28;17(1):3324. PMID: 41764166 -
Redox Biol
Synthetic anticoagulant octaparin targets mitochondrial cardiolipin-GSDMD axis to rescue redox homeostasis in sepsis. [Abstract]2025 Sep 22:87:103877. PMID: 40992080
Heparin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep 22:87:103877. [Abstract]
ELISA analysis of TNF-α in culture supernatants from BMDMs stimulated with LPS (1 μg/mL) in the presence or absence of octaparin (5 μg/mL), heparin (5 μg/mL), enoxaparin (5 μg/mL) and fondaparinux (5 μg/mL) for 24 h.
Heparin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep 22:87:103877. [Abstract]
ELISA analysis of IL-6 in culture supernatants from BMDMs stimulated with LPS (1 μg/mL) in the presence or absence of octaparin (5 μg/mL), heparin (5 μg/mL), enoxaparin (5 μg/mL) and fondaparinux (5 μg/mL) for 24 h.
Heparin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep 22:87:103877. [Abstract]
Relative fluorescence intensity of TMRM in BMDMs treated with LPS (1 μg/mL) for 24 h in the presence or absence of octaparin (5 μg/mL), heparin (5 μg/mL), enoxaparin (5 μg/mL) and fondaparinux (5 μg/mL).
Heparin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep 22:87:103877. [Abstract]
Relative fluorescence intensity of MitoSOX in BMDMs treated with LPS (1 μg/mL) for 24 h in the presence or absence of octaparin (5 μg/mL), heparin (5 μg/mL), enoxaparin (5 μg/mL) and fondaparinux (5 μg/mL).
Heparin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep 22:87:103877. [Abstract]
Relative fluorescence intensity of H2DCFDA in BMDMs treated with LPS (1 μg/mL) for 24 h in the presence or absence of octaparin (5 μg/mL), heparin (5 μg/mL), enoxaparin (5 μg/mL) and fondaparinux (5 μg/mL).
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Phytomedicine
Deciphering the core antiviral mechanism of Yinqiao powder: Inhibition of dengue virus adsorption mediated by wogonin via host receptor HSP90AA1 blockade. [Abstract]2026 Jul:156:158184. PMID: 42061084 -
Mol Med
Targeting LINC02544/miR-497-5p/CAPRIN1 axis via exosome-based siRNA to overcome immunotherapy resistance in triple-negative breast cancer. [Abstract]2025 Aug 16;31(1):278. PMID: 40819077 -
Pharmaceutics
CC-90009, a Cereblon E3 Ligase Modulator, Exhibits Antiviral Efficacy Against JEV In Vitro and In Vivo via Targeted Degradation of GSPT1 and Viral NS5 Protein. [Abstract]2025 Nov 27;17(12):1524. PMID: 41471039 -
EMBO Rep
CDC42 supports HBV entry by NTCP translocation to the plasma membrane and macropinocytosis. [Abstract]2025 Sep 15. PMID: 40954218 -
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iScience
Development of the FGFR4-ADC bearing the ferroptosis inducer sulfasalazine for hepatocellular carcinoma. [Abstract]2025 Oct 6;28(11):113718. PMID: 41210985 -
Tissue Cell
ATF5 inhibits autophagy and the Wnt/β-catenin pathway by upregulating mTOR to suppress the stemness of liver cancer stem cells. [Abstract]2025 Dec:97:103094. PMID: 40857870 -
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溶剤 & 溶解度
体外:
H2O : ≥ 100 mg/mL
* "≥" means soluble, but saturation unknown.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
純度とドキュメンテーション
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データシート (286 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Capila I, et al. Heparin-protein interactions. Angew Chem Int Ed Engl. 2002 Feb 1;41(3):391-412. [Content Brief]
[2]. Ito M, et al. Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro. Antiviral Res. 1987 Jul;7(6):361-7. [Content Brief]
[3]. Ganapathy R, et al. Effect of heparin and fractionated heparin on trophoblast invasion. Hum Reprod. 2007 Sep;22(9):2523-7. [Content Brief]
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Topics Exosomes: A Critical Tool In Cancer Therapy & Beyond
Exosomes are a subset of extracellular vesicles with an average diameter of approximately 100 nm, originate through the endosomal pathway, and carry nucleic acids, proteins, lipids, amino acids, and metabolites that can reflect the state of their parental cells; exosome research has therefore moved from a reticulocyte-maturation secretion phenomenon to a major framework for studying intercellular communication, organ homeostasis, disease progression, and biomedical applications.
2026-06-18