KB SRC 4
Based on 1 Customer Validation
KB SRC 4 is a potent, and highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM; KB SRC 4 has antitumor activity.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.22%
- CAS 番号: 1380088-03-8
- 分子式: C32H23ClN8
- 分子量:555.03
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
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| HMEC | GI50 |
4.3 μM
Compound: 1
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Cytotoxicity against human HMEC after 72 hrs by WST1 assay
Cytotoxicity against human HMEC after 72 hrs by WST1 assay
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[PMID: 24015327] |
| SK-BR-3 | GI50 |
4.8 μM
Compound: 1
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Cytotoxicity against human SK-BR-3 cells after 72 hrs by WST1 assay
Cytotoxicity against human SK-BR-3 cells after 72 hrs by WST1 assay
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[PMID: 24015327] |
KB SRC 4 (Compound 4) is a potent, highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM. KB SRC 4 is selective between Src family members, with >2-fold selectivity over both Lck (Kd, 160 nM) and Fgr (Kd, 240 nM), 8-fold selectivity over c-Yes (Kd, 720 nM), and >40-fold selectivity over Lyn (Kd, 3200 nM), Hck (Kd, 4400 nM), and Fyn (Kd, >40000 nM). KB SRC 4 inhibits the growth of cancer cell lines, with GI50s of 11 μM, 12 μM, 11 μM, 6.0 μM against HT-29, SK-BR-3, MCF7, MDA-MB-453, and NIH-3T3, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1380088-03-8
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性状 Solid
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分子量 555.03
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分子式 C32H23ClN8
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Color Light brown to brown
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SMILES
NC1=C2C(N(C3=CC=CC(C4=CN=NN4CC5=CC(C6=CC=CC=C6)=CC=C5)=C3)N=C2C7=CC=C(Cl)C=C7)=NC=N1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (180.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (251 KB)
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- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8017 mL | 9.0085 mL | 18.0170 mL | 45.0426 mL |
| 5 mM | 0.3603 mL | 1.8017 mL | 3.6034 mL | 9.0085 mL | |
| 10 mM | 0.1802 mL | 0.9009 mL | 1.8017 mL | 4.5043 mL | |
| 15 mM | 0.1201 mL | 0.6006 mL | 1.2011 mL | 3.0028 mL | |
| 20 mM | 0.0901 mL | 0.4504 mL | 0.9009 mL | 2.2521 mL | |
| 25 mM | 0.0721 mL | 0.3603 mL | 0.7207 mL | 1.8017 mL | |
| 30 mM | 0.0601 mL | 0.3003 mL | 0.6006 mL | 1.5014 mL | |
| 40 mM | 0.0450 mL | 0.2252 mL | 0.4504 mL | 1.1261 mL | |
| 50 mM | 0.0360 mL | 0.1802 mL | 0.3603 mL | 0.9009 mL | |
| 60 mM | 0.0300 mL | 0.1501 mL | 0.3003 mL | 0.7507 mL | |
| 80 mM | 0.0225 mL | 0.1126 mL | 0.2252 mL | 0.5630 mL | |
| 100 mM | 0.0180 mL | 0.0901 mL | 0.1802 mL | 0.4504 mL |
KB SRC 4 関連分類
HY-108488 関連分類
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