Oxiracetam
Based on 1 publication(s) in Google Scholar
Oxiracetam (ISF2522) is an orally active and a BBB-penetrable cyclic derivative of γ-aminobutyric acid (GABA). Oxiracetam reaches the hippocampus and cerebral cortex in high concentrations. Oxiracetam can promote cognitive function and regulate inflammatory response, with powerful neuroprotective effects. Oxiracetam can be used in the study of central nervous system diseases .
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.86%
- CAS 番号: 62613-82-5
- 分子式: C6H10N2O3
- 分子量:158.16
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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MedChemExpress（MCE）の使用を引用している文献 Oxiracetam
More
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
57.48 μM
Compound: GNF-Pf-1005
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NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
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[PMID: 18579783] |
Oxiracetam (100 μM; 12-24 h) inhibits Aβ-induced cell activation, inflammatory molecules expression and NO production in BV2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Aβ treated BV2 microglial cells
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Concentration:100 μM
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Incubation Time:12 h
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Result:Reduced the level of iNOS mRNA.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male adult Sprague-Dawley rats (220-240 g) with chronic cerebral hypoperfusion (CCH) model[2]
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Dosage:30 mg/kg
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Administration:Intraperitoneal injection (i.p.)； 4 weeks
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Result:Prevented spatial learning and memory impairment induced by CCH.
Rescued the CCH-induced LTP decrease.
Prevented the white matter lesions of CA3 nerve fibres.
Maintained BDNF levels and CREB activity in rat brains.
Prevented CCH-induced deterioration of dendritic spines and synapses.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 62613-82-5
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性状 Solid
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分子量 158.16
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分子式 C6H10N2O3
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Color White to off-white
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SMILES
O=C(N)CN1C(CC(O)C1)=O
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別名
ISF2522
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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J Nanobiotechnology
Biosynthesized nanoparticles of Tibetan medicine mercuric sulfide preparation to promote endocytosis and realize drug crossing through blood brain barrier. [Abstract]2025 Jun 16;23(1):445. PMID: 40524151
溶剤 & 溶解度
H2O : ≥ 100 mg/mL (632.27 mM)
DMSO : 25 mg/mL (158.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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参考文献
[1]. Zhang H, et al. Oxiracetam Offers Neuroprotection by Reducing Amyloid β-Induced Microglial Activation and Inflammation in Alzheimer's Disease. Front Neurol. 2020 Jul 17;11:623 [Content Brief]
[2]. Yao XL, et al. Oxiracetam can improve cognitive impairment after chronic cerebral hypoperfusion in rats. Psychiatry Res. 2016 Dec 30;246:284-292. [Content Brief]
[3]. Li W, et al. (S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats. Sci Rep. 2017 Aug 30;7(1):10052. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 6.3227 mL | 31.6136 mL | 63.2271 mL | 158.0678 mL |
| 5 mM | 1.2645 mL | 6.3227 mL | 12.6454 mL | 31.6136 mL | |
| 10 mM | 0.6323 mL | 3.1614 mL | 6.3227 mL | 15.8068 mL | |
| 15 mM | 0.4215 mL | 2.1076 mL | 4.2151 mL | 10.5379 mL | |
| 20 mM | 0.3161 mL | 1.5807 mL | 3.1614 mL | 7.9034 mL | |
| 25 mM | 0.2529 mL | 1.2645 mL | 2.5291 mL | 6.3227 mL | |
| 30 mM | 0.2108 mL | 1.0538 mL | 2.1076 mL | 5.2689 mL | |
| 40 mM | 0.1581 mL | 0.7903 mL | 1.5807 mL | 3.9517 mL | |
| 50 mM | 0.1265 mL | 0.6323 mL | 1.2645 mL | 3.1614 mL | |
| 60 mM | 0.1054 mL | 0.5269 mL | 1.0538 mL | 2.6345 mL | |
| 80 mM | 0.0790 mL | 0.3952 mL | 0.7903 mL | 1.9758 mL | |
| 100 mM | 0.0632 mL | 0.3161 mL | 0.6323 mL | 1.5807 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Oxiracetam 関連分類
HY-B1715 関連分類
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