Factor XI
Factor XI
Factor XI is an important protein in the blood coagulation cascade, and is part of the intrinsic coagulation pathway. As a zymogen, Factor XI circulates in an inactive form in the blood. When blood vessels are damaged, Factor XI is activated to Factor XIa, which then activates Factor IX, leading to the activation of Factor X. This cascade ultimately generates thrombin, promoting blood clotting, sealing the blood vessel damage, and stopping bleeding.
Factor XI is crucial for maintaining normal hemostatic function, but abnormal activity can lead to bleeding or thrombosis. Factor XI deficiency (Hemophilia C) is a genetic disorder that predisposes individuals to spontaneous or trauma-induced bleeding. On the other hand, excessive Factor XI activity is associated with thrombosis and may increase the risk of deep vein thrombosis, pulmonary embolism, and stroke[1].
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Factor XI 関連製品 (19)
関連製品 (19)
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Frunexian
0 Images製品番号: HY-156613CAS 番号: 1803270-60-1別名: EP-7041Frunexian (EP-7041) is a selective and potent inhibitor of coagulation factor XI/activated factor XI, targeting to factor XIa. Frunexian exhibits antithrombotic activity, with no bleeding liability in rat mesenteric arterial puncture model. Frunexian can be used in extracorporeal membrane oxygenation (ECMO) research.
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Pyr-Pro-Arg-pNA (hydrochloride)
0 Images別名: S-2366 (hydrochloride)Pyr-Pro-Arg-pNA (S-2366) hydrochloride is a chromogenic peptidyl substrate, and a noncompetitive inhibitor that occupies the active sites of FXIa and FXIa-LC to block factor IX activation. Pyr-Pro-Arg-pNA hydrochloride functions as a hydrolyzable substrate for FXIa’s catalytic domain, human APC, murine APC, and purified plasma kallikrein.
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ISIS 416858
0 Images製品番号: HY-134005CAS 番号: 1223657-78-0別名: FXI-ASO; BAY2306001; IONIS-FXIRxISIS 416858, a single-stranded antisense oligodeoxynucleotide, is a potent and selective inhibitor of FXI mRNA expression.
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Vortosiran
0 Images製品番号: HY-177669CAS 番号: 3061406-99-0Vortosiran, a siRNA, is a blood coagulation factor XI synthesis reducer with anticoagulant activity.
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Cenvacibart
0 Images別名: REGN-7508
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BMS-962212 hydrochloride
0 Images製品番号: HY-117290ACAS 番号: 1430115-97-1BMS-962212 hydrochloride is a selective coagulation factor XIa inhibitor and acute antithrombotic agent. BMS-962212 hydrochloride can be used in the research of thrombosis.
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Vortosiran sodium scrambled negative control
0 Images製品番号: HY-177669BVortosiran sodium scrambled negative control is the sequence scrambled negative control of Vortosiran sodium.
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Neutrophil elastase-IN-7
0 ImagesNeutrophil elastase-IN-7 (Compound 12) is an effective inhibitor of neutrophil elastase (HNE), with an IC50 value of 0.54 μM. Neutrophil elastase-IN-7 also exhibits significant inhibitory activity against various coagulation proteins, with the IC50 values for thrombin, FXa, FXIa, and FXIIIa being 8.2, 12.7, 1.2, and 5.7 μM, respectively. Neutrophil elastase-IN-7 can be used for research on inflammation, innate immune responses, and tissue remodeling.
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MK-2060
0 ImagesMK-2060 is a humanized monoclonal antibody inhibitor targeting FXI. MK-2060 can be used for atherothrombosis and venous thromboembolism research.
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Vortosiran sodium
0 Images製品番号: HY-177669AVortosiran sodium, a siRNA, is a blood coagulation factor XI synthesis reducer with anticoagulant activity.
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FXIa-IN-16
0 Images製品番号: HY-172400CAS 番号: 3046390-69-3FXIa-IN-16 (Compound 43) is an orally active and selective Factor XIa (FXIa) inhibitor with an IC50 of 0.19 nM. FXIa-IN-16 exhibits strong anticoagulant and antithrombotic activities and shows good safety in mice. FXIa-IN-16 can be used in the research related to the treatment of thrombosis.
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Bovine Factor XIa
0 Images製品番号: HY-E70393JBovine Factor XIa is an enzyme, which is involved in the intrinsic pathway of blood coagulation. Bovine Factor XIa is highly selective and exhibits a minimal extended substrate recognition site of at least five residues long. Bovine Factor XIa is reactive as Bovine Factor IXa (HY-E70393I) does, that it cleaves all the peptides bearing factor IX activation site sequences.
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Pyr-Pro-Arg-pNA
0 Images製品番号: HY-122142CAS 番号: 72194-57-1別名: S-2366Pyr-Pro-Arg-pNA (S-2366) is a chromogenic peptidyl substrate, and a noncompetitive inhibitor that occupies the active sites of FXIa and FXIa-LC to block factor IX activation. Pyr-Pro-Arg-pNA functions as a hydrolyzable substrate for FXIa’s catalytic domain, human APC, murine APC, and purified plasma kallikrein.
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Factor XI-IN-1
0 Images製品番号: HY-143477CAS 番号: 2720619-72-5Factor XI-IN-1 (Compound 27) is a factor XI activation inhibitor with an EC50 of 25.14 nM.
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FXIa/Plasma kallikrein-IN-1
0 Images製品番号: HY-150519CAS 番号: 1551460-43-5FXIa/Plasma kallikrein-IN-1 is an inhibitor of coagulation factor XIa (FXIa) and plasma kallikrein with Ki values of 187.70 nM and 151.6 nM, respectively. FXIa/Plasma kallikrein-IN-1 can be used in the research of thromboembolic diseases.
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Bemiltenase alfa
0 Images製品番号: HY-P991211CAS 番号: 2766038-73-5別名: STSP-0601Bemiltenase alfa is a hemostatic agent targeting coagulation factor X (FX). Bemiltenase alfa activates FX and promotes the conversion of prothrombin to thrombin, and thrombin can further transform fibrinogen into fibrin, forming a stable blood clot, thus exerting hemostatic activity. Bemiltenase alfa is promising for research of bleeding symptoms with hemophilia.
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Nonacog gamma
0 Images製品番号: HY-P991213別名: RixubisNonacog gamma is a coagulation factor IX (FIX) supplement. Nonacog gamma activates coagulation factor X (FX), promotes the generation of thrombin, and then converts fibrinogen into fibrin, forming a stable blood clot to exert hemostatic activity. Nonacog gamma is promising for research of hemophilia B.
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Factor XI-IN-2
0 Images製品番号: HY-175735CAS 番号: 2563884-39-7Factor XI-IN-2 is a Factor XI activation inhibitor with an IC50 of 20 nM. Factor XI-IN-2 does not directly inhibit the enzymatic activity of FXIa, but specifically binds to the FXI enzyme precursor and allosterically inhibits the process by which it is activated by FXIIa. Factor XI-IN-2 inhibits thrombosis in the rabbit arteriovenous (AV) shunt thrombosis model. Factor XI-IN-2 can be used for the study of antithrombus.
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