A-1211212
Based on 1 Customer Validation
A-1211212 (BCL2-IN-1), a chemical probe, is a potent Bcl-2 inhibitor. BCL2-IN-1 binds Bcl-2 with a Ki of <0.01 nM.
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- 純度: 98.43%
- CAS 番号: 1257044-75-9
- 分子式: C47H54ClN7O7S
- 分子量:896.49
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLT-4 | EC50 |
>5000 nM
Compound: A-1211212
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Antiproliferative activity against Bcl-xl dependent human MOLT-4 cells assessed as reduction in cell viability by measuring effect concentration by CellTiter-Glo reagent based assay
Antiproliferative activity against Bcl-xl dependent human MOLT-4 cells assessed as reduction in cell viability by measuring effect concentration by CellTiter-Glo reagent based assay
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[PMID: 25787766] |
| MOLT-4 | EC50 |
6 nM
Compound: A-1211212
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Antiproliferative activity against Bcl-2 dependent human MOLT-4 cells assessed as reduction in cell viability by measuring effect concentration by CellTiter-Glo reagent based assay
Antiproliferative activity against Bcl-2 dependent human MOLT-4 cells assessed as reduction in cell viability by measuring effect concentration by CellTiter-Glo reagent based assay
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[PMID: 25787766] |
| MOLT-4 | EC50 |
>5000 nM
Compound: 22
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Antiproliferative activity against human MOLT4 cells in presence of 10% human serum
Antiproliferative activity against human MOLT4 cells in presence of 10% human serum
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[PMID: 28926247] |
| RS4-11 | EC50 |
6 nM
Compound: 22
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Antiproliferative activity against human RS4:11 cells in presence of 10% human serum
Antiproliferative activity against human RS4:11 cells in presence of 10% human serum
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[PMID: 28926247] |
化学情報
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CAS 番号 1257044-75-9
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性状 Solid
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分子量 896.49
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分子式 C47H54ClN7O7S
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Color White to yellow
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SMILES
O=C(NS(=O)(C1=CC=C(NC[C@H]2CC[C@H](OC)CC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)CC4)C=C3OC7=CN=C(NC=C8)C8=C7
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別名
BCL2-IN-1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (111.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1155 mL | 5.5773 mL | 11.1546 mL | 27.8865 mL |
| 5 mM | 0.2231 mL | 1.1155 mL | 2.2309 mL | 5.5773 mL | |
| 10 mM | 0.1115 mL | 0.5577 mL | 1.1155 mL | 2.7887 mL | |
| 15 mM | 0.0744 mL | 0.3718 mL | 0.7436 mL | 1.8591 mL | |
| 20 mM | 0.0558 mL | 0.2789 mL | 0.5577 mL | 1.3943 mL | |
| 25 mM | 0.0446 mL | 0.2231 mL | 0.4462 mL | 1.1155 mL | |
| 30 mM | 0.0372 mL | 0.1859 mL | 0.3718 mL | 0.9296 mL | |
| 40 mM | 0.0279 mL | 0.1394 mL | 0.2789 mL | 0.6972 mL | |
| 50 mM | 0.0223 mL | 0.1115 mL | 0.2231 mL | 0.5577 mL | |
| 60 mM | 0.0186 mL | 0.0930 mL | 0.1859 mL | 0.4648 mL | |
| 80 mM | 0.0139 mL | 0.0697 mL | 0.1394 mL | 0.3486 mL | |
| 100 mM | 0.0112 mL | 0.0558 mL | 0.1115 mL | 0.2789 mL |
A-1211212 関連分類
HY-135273 関連分類
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