ABS-752
ABS-752 is a potent and orally active GSPT1 and NEK7 molecular glue degrader. ABS-752 shows cytotoxicity. ABS-752 decreases the protein expression of GSPT1 and SALL4, NEK7. ABS-752 is a prodrug activated by the monoamine oxidase, VAP-1, to an aldehyde intermediate and subsequently to the active molecule, ABT-002 (HY-175283). ABS-752 has the potential for the research of hepatocellular carcinoma.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2761170-84-5
- 分子式: C14H14FN3O3
- 分子量:291.28
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NSG mice (Hep3B cells)[1]
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Dosage:1, 3, 10 mg/kg
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Administration:Po; daily for 14 days
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Result:Showed anticancer activity in a dose-dependent manner.
化学情報
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CAS 番号 2761170-84-5
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分子量 291.28
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分子式 C14H14FN3O3
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SMILES
O=C(C(N(CC1=C2C=C(F)C(CN)=C1)C2=O)CC3)NC3=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ABS-752 関連分類
HY-W599279 関連分類
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