ADS032
Based on 4 publication(s) in Google Scholar
ADS032 is a sulfonylurea compound that is an NLRP1 and NLRP3 inflammasome inhibitor. ADS032 reduces the secretion of inflammatory factors and inhibits the oligomerization of ASC. ADS032 has anti-inflammatory effects in a variety of inflammatory models and can be used in the study of inflammatory diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.89%
- CAS 番号: 2757333-37-0
- 分子式: C22H29NO4S
- 分子量:403.53
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 ADS032
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生物活性
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NLRP1 |
NLRP3 |
ADS032 (20 mg/kg; nasal administration; 2-3 doses) protects mice from severe IAV disease and reduces lung inflammation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LPS (HY-D1056) treated C57BL/6 mice [1]
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Dosage:200 mg/kg
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Administration:Intraperitoneal injection (i.p.); single dose
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Result:Significantly reduced levels of circulating inflammatory cytokines IL-1β, TNF-α and IFN-γ, while IL-10 was not affected.
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Animal Model:HKx31 (an IAV relative to PR8) treated C57BL/6 mice[1]
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Dosage:20 mg/kg
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Administration:Nasal administration; 2-3 doses: days 1, 3 and 5 or days 3 and 5 post-IAV infection (day 0)
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Result:Reduced the weight loss and mortality of mice.
Did not induce any noticeable pulmonary inflammation itself.
Reduced IL-6, TNF-a and MCP-1 BALF concentrations.
Reduced total cellular infiltrates in the lungs, characterised by significantly reduced neutrophils, macrophages and dendritic cells.
化学情報
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CAS 番号 2757333-37-0
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性状 Solid
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分子量 403.53
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分子式 C22H29NO4S
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Color White to light yellow
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SMILES
O=C(CCCC1=CC=C(C2=CC=C(S(=O)(N(CCC)CCC)=O)C=C2)C=C1)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
DMSO : 100 mg/mL (247.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 12.5 mg/mL (30.98 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 2.4781 mL | 12.3907 mL | 24.7813 mL | 61.9533 mL |
| 5 mM | 0.4956 mL | 2.4781 mL | 4.9563 mL | 12.3907 mL | |
| 10 mM | 0.2478 mL | 1.2391 mL | 2.4781 mL | 6.1953 mL | |
| 15 mM | 0.1652 mL | 0.8260 mL | 1.6521 mL | 4.1302 mL | |
| 20 mM | 0.1239 mL | 0.6195 mL | 1.2391 mL | 3.0977 mL | |
| 25 mM | 0.0991 mL | 0.4956 mL | 0.9913 mL | 2.4781 mL | |
| 30 mM | 0.0826 mL | 0.4130 mL | 0.8260 mL | 2.0651 mL | |
| DMSO | 40 mM | 0.0620 mL | 0.3098 mL | 0.6195 mL | 1.5488 mL |
| 50 mM | 0.0496 mL | 0.2478 mL | 0.4956 mL | 1.2391 mL | |
| 60 mM | 0.0413 mL | 0.2065 mL | 0.4130 mL | 1.0326 mL | |
| 80 mM | 0.0310 mL | 0.1549 mL | 0.3098 mL | 0.7744 mL | |
| 100 mM | 0.0248 mL | 0.1239 mL | 0.2478 mL | 0.6195 mL |
ADS032 関連分類
HY-156798 関連分類
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