Alloxazine
Based on 1 Customer Validation
Alloxazine is a selective A2b antagonist. Alloxazine completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.46%
- CAS 番号: 490-59-5
- 分子式: C10H6N4O2
- 分子量:214.18
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Adenosine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
IC50: 2.9 μM (AMP)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
>50 μM
Compound: 62
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Inhibitory activity against platelet-derived growth factor receptor tyrosine kinase in Swiss 3T3 cells
Inhibitory activity against platelet-derived growth factor receptor tyrosine kinase in Swiss 3T3 cells
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[PMID: 8667360] |
Alloxazine (0-30 μM, 20 min) inhibits cyclic AMP production in PGT-β cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PGT-β cells
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Concentration:0-30 μM
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Incubation Time:20 min
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Result:Inhibited the cyclic AMP generation concentration-dependently with an IC50 of 2.9 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats[2]
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Dosage:1 µmol/L
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Administration:Cortical surface suffusion; 1 µmol/L once
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Result:Significantly suppressed vasodilation with increased EC25 value of 0.60 µmol/L.
化学情報
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CAS 番号 490-59-5
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性状 Solid
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分子量 214.18
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分子式 C10H6N4O2
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Color Light yellow to yellow
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SMILES
O=C(N1)N=C2NC3=CC=CC=C3N=C2C1=O
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別名
Isoalloxazine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 5 mg/mL (23.34 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
[1]. Brackett LE, Daly JW. Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts. Biochem Pharmacol. 1994 Mar 2;47(5):801-14. [Content Brief]
[2]. Shin HK, et al. Role of adenosine A(2B) receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation. Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H339-44. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.6690 mL | 23.3449 mL | 46.6897 mL | 116.7243 mL |
| 5 mM | 0.9338 mL | 4.6690 mL | 9.3379 mL | 23.3449 mL | |
| 10 mM | 0.4669 mL | 2.3345 mL | 4.6690 mL | 11.6724 mL | |
| 15 mM | 0.3113 mL | 1.5563 mL | 3.1126 mL | 7.7816 mL | |
| 20 mM | 0.2334 mL | 1.1672 mL | 2.3345 mL | 5.8362 mL |
Alloxazine 関連分類
HY-123085 関連分類
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