Antimalarial agent 59
Antimalarial agent 59 is an antimalarial agent. Antimalarial agent 59 inhibits the growth of Chloroquine (HY-17589A)-resistant FcB1 strain of Plasmodium falciparum with an IC50 of 46 nM. Antimalarial agent 59 also shows cytotoxic activity against cancer cells. Antimalarial agent 59 can be used for the researches of malaria and ovarian cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3103602-12-3
- 分子式: C17H24O7
- 分子量:340.37
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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生物活性
Antimalarial agent 59 (Compound 5i) (48 h) potently inhibits the growth of Chloroquine (HY-17589A)-resistant FcB1 strain of Plasmodium falciparum with an IC50 of 46 nM and a selectivity index of 232[1].
Antimalarial agent 59 (72 h) inhibits the growth of HeLa cervical cancer cells with an LD50 of 10.85 μM[1].
Antimalarial agent 59 (1-10 μM; 24-72 h) reduces A2780 ovarian cancer cell viability in a concentration- and time-dependent manner, with near-complete inhibition at 10 μM after 48 and 72 h[1].
Antimalarial agent 59 (1-10 μM; 72 h) inhibits the growth of A2780 ovarian cancer cells with an IC50 of 3.82 ± 1.38 μM after 72 h of incubation[1].
Antimalarial agent 59 (1-10 μM; 24-72 h) reduces A549 lung adenocarcinoma cell viability in a concentration- and time-dependent manner, with the strongest inhibition (15.75% viability) observed at 10 μM after 72 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A2780 ovarian cancer cells
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Concentration:1, 10 μM
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Incubation Time:24, 48, 72 h
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Result:Reduced cell viability to 67.38% at 1 μM (24 h).
Reduced cell viability to 79.57% at 1 μM (48 h).
Reduced cell viability to 92.20% at 1 μM (72 h).
Reduced cell viability to 2.19% at 10 μM (24 h).
Reduced cell viability to 0.04% at 10 μM (48 h).
Reduced cell viability to 1.03% at 10 μM (72 h).
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Cell Line:A549 lung adenocarcinoma cells
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Concentration:1, 10 μM
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Incubation Time:24, 48, 72 h
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Result:Reduced cell viability to 99.03% at 1 μM (24 h).
Reduced cell viability to 92.09% at 1 μM (48 h).
Reduced cell viability to 97.16% at 1 μM (72 h).
Reduced cell viability to 32.81% at 10 μM (24 h).
Reduced cell viability to 19.87% at 10 μM (48 h).
Reduced cell viability to 15.75% at 10 μM (72 h).
化学情報
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CAS 番号 3103602-12-3
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分子量 340.37
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分子式 C17H24O7
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SMILES
COC1=CC=C(C2OOC3(CCC(C)CC3)OO2)C(OC)=C1OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antimalarial agent 59 関連分類
HY-181658 関連分類
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- Antimalarial agent 59
- 3103602-12-3
- Antimalarial agent59
- Antimalarial agent-59
- Parasite
- malaria
- A549 lung adenocarcinoma cells
- ovarian cancer cells
- Plasmodium falciparum
- HeLa cervical cancer cells
- A2780 ovarian cancer cells
- chloroquine-resistant FcB1 strain
- cervical cancer cells
- ovarian cancer
- Inhibitor
- inhibitor
- inhibit