APG808
APG808 (PR001) is an anti-human IL-4Rα monoclonal antibody. APG808 binds to IL-4Rα, prevents IL-13Rα1/IL-4Rα heterodimer formation, and disrupts IL-13 and IL-4 mediated signaling. APG808 ablates Fc and complement effector functions. APG808 can be used for the research of chronic obstructive pulmonary disease, asthma, atopic dermatitis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Human IgG1 kappa
Human
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IL-4Rα/IL4R/CD124 |
APG808 has a high affinity for human FcRn at pH 6.0, reduced affinity for human FcγRI, FcγRIIIa (F158), and FcγRIIIa (V158), and no detectable binding to human FcγRIIa (H131), FcγRIIa (R131), FcγRIIIb, or C1q[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | AUC0-inf | CL | Vss | Bioavailability | T1/2 |
|---|---|---|---|---|---|---|---|
| Cynomolgus Monkey[1] | 25.9 mg/kg | s.c. | 9.77 × 106 ng·h/mL | 2.79 | 101.80 mL/kg | 97.51 % | 27.18 |
IL-4Ra/CD124
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
化学情報
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SMILES
[APG808]
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別名
PR001
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
APG808 関連分類
HY-P992034 関連分類
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