ARN24139
ARN24139(compound 3f) is a topoisomerase II (topoII) inhibitor with the IC50 of 7.3 μM. ARN24139 can inhibit cancer cell proliferation and is well tolerated in vivo.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2699768-78-8
- 分子式: C24H16F3N3O4S
- 分子量:499.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Topoisomerase アイソフォーム固有の製品をすべて表示
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生物活性
ARN24139(compound 3f) has antiproliferative activity on DU145, HeLa and A549 cells with the IC50 values of 4.7, 3.8 and 3.1μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Parameter | IV (3 mg/kg) | PO (10 mg/kg) |
| Cmax(ng/mL) | 7366 | 428 |
| Tmax(min) | 5 | 120 |
| AUCplasma(min*ng/mL) | 295528 | 77385 |
| t1/2(min) | 30 | 190 |
| Vd(L/kg) | 3 | 18 |
| CL(L/min/kg) | 0.004 | - |
| F(%) | 8 | 8 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2699768-78-8
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分子量 499.46
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分子式 C24H16F3N3O4S
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SMILES
O=C(C1C(N(C(N(C2=CC=CC=C2)C1=O)=S)C3=CC=CC=C3)=O)NC4=CC(OC(F)(F)F)=CC=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ARN24139 関連分類
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