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製品番号: HY-11010A

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AS601245 TFA

Name: AS601245 TFA
Brand: MedChemExpress
SKU: HY-11010A
Availability: PreOrder

9 Cited Publications

カスタマーレビュー

Based on 9 publication(s) in Google Scholar

AS601245 TFA is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC₅₀s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 TFA exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 345987-16-8
分子式: C₂₄H₁₈F₆N₆O₄S
分子量:600.49

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

AS601245 TFA 構造式

CAS 番号: 345987-16-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

JNK アイソフォーム固有の製品をすべて表示 :

体外実験

AS601245, an anti-Inflammatory JNK inhibitor, and Clofibrate have a synergistic effect in inducing cell responses and in affecting the gene expression profile in CaCo-2 colon cancer cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

AS601245 (40, 60, and 80 mg/kg; i.p.) provides significant protection against the delayed loss of hippocampal CA1 neurons in a gerbil model of transient global ischemia^[1].
AS601245 (0.3-10 mg/kg; p.o.) is a potent inhibitor of LPS-induced TNF-α release in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C3H/HEN mice^[1]
Dosage:

0.3, 1, 3, or 10 mg/kg
Administration:

P.o.
Result:

Decreased the TNF-α release in a dose-dependent manner.

化学情報

CAS 番号 345987-16-8
分子量 600.49
分子式 C₂₄H₁₈F₆N₆O₄S
SMILES

N#CC(C1=CC=NC(NCCC2=CC=CN=C2)=N1)C3=NC4=CC=CC=C4S3.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (9)

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Nat Commun

Myocardial mitochondrial antiviral signaling protein promotes heart Ischemia-reperfusion injury via RIG-I signaling in mice. [Abstract]

2025 Jun 2;16(1):5101. PMID: 40456736
Nat Commun

Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation. [Abstract]

2021 Nov 16;12(1):6607. PMID: 34785661
EMBO Mol Med

Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice. [Abstract]

2025 Nov 26. PMID: 41299101
Cell Rep

circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells. [Abstract]

2022 Nov 22;41(8):111707. PMID: 36417875
J Ethnopharmacol

Shenqisherong pill ameliorates neuronal apoptosis by inhibiting the JNK/caspase-3 signaling pathway in a rat model of cervical cord compression. [Abstract]

2024 Jan 10;318(Pt A):116901. PMID: 37437792
Cell Biol Toxicol

Shikonin inhibits neuronal apoptosis via regulating endoplasmic reticulum stress in the rat model of double-level chronic cervical cord compression. [Abstract]

2023 Jun;39(3):907-928. PMID: 35028790
ACS Omega

The Role and Efficacy of JNK Inhibition in Inducing Lung Cancer Cell Death Depend on the Concentration of Cisplatin. [Abstract]

2024 Jun 18;9(26):28311-28322. PMID: 38973918
Npj Viruses

JNK kinase regulates phosphorylation of HCoV-229E nucleocapsid protein. [Abstract]

2025 Sep 18;3(1):69. PMID: 40968155
Theriogenology

Signaling pathways of Periplaneta americana peptide resist H2O2-induced apoptosis in pig-ovary granulosa cells through FoxO1. [Abstract]

2022 Apr 15:183:108-119. PMID: 35247848

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Carboni S, et al. AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties. J Pharmacol Exp Ther. 2004;310(1):25-32. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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AS601245 TFA

9 Cited Publications

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生物活性
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化学情報
Publications (9)
純度とドキュメンテーション
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AS601245 TFA

MedChemExpress（MCE）の使用を引用している文献 AS601245 TFA

JNK アイソフォーム固有の製品をすべて表示

生物活性

製品説明

体外実験

体内実験

化学情報

Publications (9)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bioz

Keywords

最近チェックした製品

AS601245 TFA

MedChemExpress（MCE）の使用を引用している文献 AS601245 TFA

JNK アイソフォーム固有の製品をすべて表示

生物活性

製品説明

体外実験

体内実験

化学情報

Publications (9)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

AS601245 TFA 関連分類

HY-11010A 関連分類

Bioz

Keywords

最近チェックした製品