BDM91531
BDM91531 is a AcrB inhibitor with an EC50 of 0.16 μM against E. coli. BDM91531 acts as an antibiotic potentiator to restore the sensitivity of wild-type Escherichia coli to multiple AcrB substrate antibiotics. BDM91531 exhibits antibacterial activity. BDM91531 can be used in the research of bacterial infections.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2892824-73-4
- 分子式: C20H21ClN4
- 分子量:352.86
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Antibiotic アイソフォーム固有の製品をすべて表示
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生物活性
BDM91531 (Compound 6) (4.5 h) potently enhances the activity of AcrB substrate antibiotics in wild-type E. coli BW25113 by inhibiting the AcrAB-TolC efflux pump, with an EC90 of 0.24 μM against pyridomycin[1].
BDM91531 (20 min) binds tightly to purified wild-type E. coli AcrB, induces its thermal stability, with a half-effective concentration of approximately 156 nM[1].
BDM91531 (0-5 μM; 16 h) induces concentration-dependent growth inhibition in E. coli BW25113ΔacrB complementarily expressing wild-type AcrB in the presence of Erythromycin (HY-B0220), and its activity depends on the negatively charged residues (E947, D951) at the cytoplasmic rim of AcrB[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2892824-73-4
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分子量 352.86
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分子式 C20H21ClN4
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SMILES
NCC1=CC(C(C=C2)=CC3=C2N=C(N4CCNCC4)C(Cl)=C3)=CC=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BDM91531 関連分類
HY-183702 関連分類
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