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Benzenesulphonamide (Compound 1) is a carbonic anhydrase inhibitor. Benzenesulphonamide exhibits CA II inhibitory activity. Benzenesulphonamide reduces ROS and improves the gene expression of amyloid-β40 and 42. Benzenesulphonamide is beneficial for Alzheimer's disease. Benzenesulphonamide derivatives have anticancer, anti-inflammatory, and anticonvulsant activities. Benzenesulphonamide can be used in the research of Alzheimer's disease, epilepsy, inflammatory diseases, leukemia, melanoma, lung cancer, and colon cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.75%
- CAS 番号: 98-10-2
- 分子式: C6H7NO2S
- 分子量:157.19
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保管条件:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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FDA Approved & Pharmacopeial Drug Library
HY-L066
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Anti-Alzheimer's Disease Compound Library
HY-L069
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
生物活性
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CA Ⅱ |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 98-10-2
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性状 Solid
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分子量 157.19
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分子式 C6H7NO2S
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Color White to off-white
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SMILES
O=S(C1=CC=CC=C1)(N)=O
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別名
Benzenesulphonamide
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
DMSO : 100 mg/mL (636.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Thakur A, et al. QSAR study on benzenesulphonamide carbonic anhydrase inhibitors: topological approach using Balaban index. Bioorg Med Chem. 2004 Feb 15;12(4):789-93. [Content Brief]
[2]. Hesar Shourkabi M, et al. Benzenesulfonamide as a novel, pharmaceutical small molecule inhibitor on Aβ gene expression and oxidative stress in Alzheimer's Wistar rats. Biochem Biophys Res Commun. 2023 Sep 24;674:154-161. [Content Brief]
[3]. Bashir R, et al. Synthesis of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide as anticancer and anti-inflammatory agents. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4301-5. [Content Brief]
[4]. Nissan YM, et al. New benzenesulfonamide scaffold-based cytotoxic agents: Design, synthesis, cell viability, apoptotic activity and radioactive tracing studies. Bioorg Chem. 2020 Mar;96:103577. [Content Brief]
[5]. Wang Z, et al. Synthesis and Pharmacological Evaluation of Novel Benzenesulfonamide Derivatives as Potential Anticonvulsant Agents. Molecules. 2015 Sep 23;20(9):17585-600. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.3617 mL | 31.8086 mL | 63.6173 mL | 159.0432 mL |
| 5 mM | 1.2723 mL | 6.3617 mL | 12.7235 mL | 31.8086 mL | |
| 10 mM | 0.6362 mL | 3.1809 mL | 6.3617 mL | 15.9043 mL | |
| 15 mM | 0.4241 mL | 2.1206 mL | 4.2412 mL | 10.6029 mL | |
| 20 mM | 0.3181 mL | 1.5904 mL | 3.1809 mL | 7.9522 mL | |
| 25 mM | 0.2545 mL | 1.2723 mL | 2.5447 mL | 6.3617 mL | |
| 30 mM | 0.2121 mL | 1.0603 mL | 2.1206 mL | 5.3014 mL | |
| 40 mM | 0.1590 mL | 0.7952 mL | 1.5904 mL | 3.9761 mL | |
| 50 mM | 0.1272 mL | 0.6362 mL | 1.2723 mL | 3.1809 mL | |
| 60 mM | 0.1060 mL | 0.5301 mL | 1.0603 mL | 2.6507 mL | |
| 80 mM | 0.0795 mL | 0.3976 mL | 0.7952 mL | 1.9880 mL | |
| 100 mM | 0.0636 mL | 0.3181 mL | 0.6362 mL | 1.5904 mL |
Benzenesulphonamide 関連分類
HY-101087 関連分類
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