Bethoxazin
Based on 1 Customer Validation
Bethoxazin is a yeast DNA topoisomerase II inhibitor with an IC50 of 5.3 μM, and also a broad-spectrum industrial microbicide and covalent adduct-forming agent. Bethoxazin inhibits the catalytic activity of yeast DNA topoisomerase II by reacting with the key free cysteine thiol group on the enzyme. Bethoxazin forms covalent adducts with molecules containing free thiol groups. Bethoxazin inhibits the growth of yeast cells. Bethoxazin can be used in studies related to the growth of fungi, molds and algae.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.45%
- CAS 番号: 163269-30-5
- 分子式: C11H9NO2S2
- 分子量:251.32
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Bethoxazin (30-100 μM) is highly reactive toward free sulfhydryl groups (GSH, cysteine, HSA) but does not react with amino, carboxylic, phenolic, amino oxo, alcoholic, or phosphate functional groups under tested conditions[1].
Bethoxazin (100 μM; 8 h) undergoes nucleophilic attack at C3 of its oxathiazine oxide ring by sulfhydryl groups, forming ring-opened intermediates that react with a second sulfhydryl molecule to produce disulfide adducts[1].
Bethoxazin (66 μM; 5 h) forms a covalent adduct with free human serum albumin at an equimolar ratio, reacting with the single free cysteine residue of HSA[1].
Bethoxazin (0.01-100 μM; 6 h) potently inhibits the growth of yeast BY4742 cells with an IC50 of 11 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:yeast BY4742 strain
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Concentration:0.01, 0.1, 1, 10 and 100 μM
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Incubation Time:6 h
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Result:Inhibited yeast cell growth in a concentration-dependent manner, with an IC50 of 11 μM.
化学情報
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CAS 番号 163269-30-5
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性状 Solid
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分子量 251.32
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分子式 C11H9NO2S2
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Color Light yellow to light brown
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SMILES
O=S1C(C2=CC3=CC=CC=C3S2)=NOCC1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 25 mg/mL (99.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9790 mL | 19.8950 mL | 39.7899 mL | 99.4748 mL |
| 5 mM | 0.7958 mL | 3.9790 mL | 7.9580 mL | 19.8950 mL | |
| 10 mM | 0.3979 mL | 1.9895 mL | 3.9790 mL | 9.9475 mL | |
| 15 mM | 0.2653 mL | 1.3263 mL | 2.6527 mL | 6.6317 mL | |
| 20 mM | 0.1989 mL | 0.9947 mL | 1.9895 mL | 4.9737 mL | |
| 25 mM | 0.1592 mL | 0.7958 mL | 1.5916 mL | 3.9790 mL | |
| 30 mM | 0.1326 mL | 0.6632 mL | 1.3263 mL | 3.3158 mL | |
| 40 mM | 0.0995 mL | 0.4974 mL | 0.9947 mL | 2.4869 mL | |
| 50 mM | 0.0796 mL | 0.3979 mL | 0.7958 mL | 1.9895 mL | |
| 60 mM | 0.0663 mL | 0.3316 mL | 0.6632 mL | 1.6579 mL | |
| 80 mM | 0.0497 mL | 0.2487 mL | 0.4974 mL | 1.2434 mL |
Bethoxazin 関連分類
HY-17525 関連分類
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