BIEGi-1
BIEGi-1 is an EGFR inhibitor. BIEGi-1 effectively disrupts the EGFR-Rheb interaction in cells. BIEGi-1 robustly inhibits EGFR kinase activity (reduces p-Y1068-EGFR) as well as mTORC1 activation (reduces p-T389-S6K1) in EGFR-mutant cells. BIEGi-1 shows strong antiproliferative effects on EGFR-mutant PC9 and HCC827 cells with IC50 values of 17 nM and 20 nM, respectively. BIEGi-1 can be used for the study of cancers harboring EGFR mutations, such as non-small cell lung cancer (NSCLC).
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- CAS 番号: 1429497-30-2
- 分子式: C36H37N7O3
- 分子量:615.72
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
EGFR アイソフォーム固有の製品をすべて表示
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生物活性
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mTORC1 |
BIEGi-1 (25 nM, 12 h) effectively disrupts the interaction between EGFR and Rheb in PC9 cells (EGFR-mutant)[1].
BIEGi-1 (25 nM, 12 h) robustly inhibits EGFR kinase activity (reduces p-Y1068-EGFR) and mTORC1 activation (reduces p-T389-S6K1) in EGFR-mutant PC9 and HCC827 cells[1].
BIEGi-1 (0.01-10000 nM, 72 h) exerts strong antiproliferative effects on PC9 and HCC827 cells, with IC50 values of 17 nM and 20 nM, respectively[1].
BIEGi-1 (200 nM, 24 h) inhibits mTORC1 activation induced by lysosome-localized LAMP2-V5-EGFR-TKD (WT and KD) in serum-starved HEK-293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:EGFR-mutant PC9 and HCC827 cells
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Concentration:25 nM
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Incubation Time:12 h
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Result:Reduced p-Y1068-EGFR and p-T389-S6K1 in EGFR-mutant PC9 and HCC827 cells.
化学情報
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CAS 番号 1429497-30-2
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分子量 615.72
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分子式 C36H37N7O3
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SMILES
O=C1N(C2=CC(NC(/C=C/C)=O)=CC=C2)C3=NC(NC4=C(C=C(N5CCN(CC5)C)C=C4)OC)=NC=C3C=C1CC6=CC=CC=C6
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BIEGi-1 関連分類
HY-17654 関連分類
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