Biflorin
Biflorin has antimicrobial, antitumor, antiinflammatory and antimutagenic activities. Biflorin is found in the roots of Capraria biflora L.
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- 純度: 99.54%
- CAS 番号: 89701-85-9
- 分子式: C16H18O9
- 分子量:354.31
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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STAT1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
140 μM
Compound: 1
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Cytotoxicity against mouse RAW264.7 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as decrease in cell viability after 24 hrs by MTT assay
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[PMID: 26977531] |
| RAW264.7 | IC50 |
37.1 μM
Compound: 1
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production preincubated for 1 hr followed by LPS challenge for 24 hrs by ELISA method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production preincubated for 1 hr followed by LPS challenge for 24 hrs by ELISA method
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[PMID: 26977531] |
| RAW264.7 | IC50 |
51.7 μM
Compound: 1
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 1 hr followed by LPS challenge for 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 1 hr followed by LPS challenge for 24 hrs by Griess assay
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[PMID: 26977531] |
Biflorin (72 h) inhibits tumor cell growth with IC50s ranging from 0.58 μg/mL (NCIH23 cell) to 14.61 μg/mL (MDA-MB-231 cell)[1].
Biflorin (3 and 6 μg/mL, 24 h) induces apoptosis, internucleosomal DNA fragmentation, mitochondrial depolarization in B16 melanoma cells[1].
Biflorin inhibits LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2) in RAW 264.7 macrophages via STAT1 Inactivation, with IC50 s of 51.7 and 37.1 μM, respectively[2].
Biflorin (5 and 10 μg/mL, 3 h) inhibits H2O2-induced oxidative damage by reducing lipid peroxidation and DNA damage in V79 mammalian cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 89701-85-9
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性状 Solid
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分子量 354.31
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分子式 C16H18O9
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Color White to off-white
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SMILES
O=C1C=C(C)OC2=CC(O)=C([C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C(O)=C12
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (282.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Vasconcellos MC, et al. The in-vitro and in-vivo inhibitory activity of biflorin in melanoma. Melanoma Res. 2011 Apr;21(2):106-14. [Content Brief]
[2]. Lee HH, et al. Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock. J Nat Prod. 2016 Apr 22;79(4):711-20. [Content Brief]
[3]. Vasconcellos MC,et al. Evaluation of the cytotoxic and antimutagenic effects of biflorin, an antitumor 1,4 o-naphthoquinone isolated from Capraria biflora L. Arch Toxicol. 2010 Oct;84(10):799-810. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8224 mL | 14.1119 mL | 28.2239 mL | 70.5597 mL |
| 5 mM | 0.5645 mL | 2.8224 mL | 5.6448 mL | 14.1119 mL | |
| 10 mM | 0.2822 mL | 1.4112 mL | 2.8224 mL | 7.0560 mL | |
| 15 mM | 0.1882 mL | 0.9408 mL | 1.8816 mL | 4.7040 mL | |
| 20 mM | 0.1411 mL | 0.7056 mL | 1.4112 mL | 3.5280 mL | |
| 25 mM | 0.1129 mL | 0.5645 mL | 1.1290 mL | 2.8224 mL | |
| 30 mM | 0.0941 mL | 0.4704 mL | 0.9408 mL | 2.3520 mL | |
| 40 mM | 0.0706 mL | 0.3528 mL | 0.7056 mL | 1.7640 mL | |
| 50 mM | 0.0564 mL | 0.2822 mL | 0.5645 mL | 1.4112 mL | |
| 60 mM | 0.0470 mL | 0.2352 mL | 0.4704 mL | 1.1760 mL | |
| 80 mM | 0.0353 mL | 0.1764 mL | 0.3528 mL | 0.8820 mL | |
| 100 mM | 0.0282 mL | 0.1411 mL | 0.2822 mL | 0.7056 mL |
Biflorin 関連分類
HY-119956 関連分類
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