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製品番号: HY-183248

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BRDT-IN-2

BRDT-IN-2 is a BRDT-BD1-preferring inhibitor (K_i=10 μM) with higher affinity for BRDT-BD1 than BRD4-BD1. BRDT-IN-2 preferentially binds BRDT-BD1 without direct interaction with BRDT-BD1’s Arg54 residue. BRDT-IN-2 binds BRD4-BD1 with lower affinity via structured water molecule displacement in its binding pocket. BRDT-IN-2 can be used for the research of multiple myeloma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₃₃H₄₁FN₈O₈S
分子量:728.79

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

BRDT-IN-2 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

BRDT (BD1)

Epigenetic Reader Domain アイソフォーム固有の製品をすべて表示 :

体外実験

BRDT-IN-2 inhibits the growth of MM.1S multiple myeloma cells with an IC₅₀ of 6.8 μM^[1].
BRDT-IN-2 (0.039-10.000 μM; 6 h) dose-dependently downregulates the expression of c-Myc protein in MM.1S multiple myeloma cells in in vitro treatments^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MM.1S multiple myeloma cells
Concentration:

0.1% (final DMSO concentration)
Incubation Time:

72 hours (37 °C, 5% CO₂)
Result:

Inhibited MM.1S cell growth with an IC₅₀ value of 6.8 μM.
Was less potent than reference inhibitors JQ1 (IC₅₀ = 0.12 μM) and I-BET151 (IC₅₀ = 0.33 μM).

Western Blot Analysis^[1]

Cell Line:

MM.1S multiple myeloma cells
Concentration:

0.039-10.000 μM
Incubation Time:

6 hours (37 °C, 5% CO₂)
Result:

Dose-dependently suppressed c-Myc protein levels.
Caused measurable reduction of c-Myc protein levels at concentrations ≥0.630 μM relative to untreated control cells.

化学情報

分子量 728.79
分子式 C₃₃H₄₁FN₈O₈S
SMILES

CC1=C(NC2=CC(C(N[C@@H](CCC(O)=O)C(O)=O)=O)=CC(NS(=O)(C(C)(C)C)=O)=C2)N=C(NC3=CC(F)=C(C(NC4CCNCC4)=O)C=C3)N=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Liang T, et al. Structural Basis for BD1-Preferring 2,4-Disubstituted Pyrimidine BRDT Inhibitors. J Med Chem. Published online April 15, 2026. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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BRDT-IN-2

Epigenetic Reader Domain アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

BRDT-IN-2 関連分類

HY-183248 関連分類