BRP
Based on 1 Customer Validation
BRP is a 12-peptide derived from BRINP2 that can cross the blood-brain barrier. BRP induces the central activation of FOS in neuronal cells via the cAMP-PKA-CREB signaling pathway. BRP exerts anorectic and anti-obesity effects without triggering nausea or aversive responses. The action of BRP is independent of the leptin, GLP-1 receptor and melanocortin 4 receptor pathways. BRP is applicable to obesity-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.62%
- 分子式: C68H117N25O14S
- 分子量:1540.88
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
BRP (50-100 μg/mL; 0-24 h) induces potent, sustained, and non-desensitizing Fos expression in NS-1 rat neuronal cells, with EC50 values of 33.7 μM at 24 h and 37 μM at 1 h[1].
BRP (50-100 μg/ml; 0-24 h) induces potent, sustained and non-desensitizing Fos expression in mouse Neuro2a neuronal cells, with EC50 values of 33 μM at 24 h and 27 μM at 1 h, and activates the CREB and ERK1/2 signaling pathways[1].
BRP (100 μg/mL; 0-40 min) increases intracellular cAMP levels in Neuro2a mouse neuronal cells[1].
BRP (100 μg/mL; 15 min) induces phosphorylation of CREB at Ser133, phosphorylation of ERK1/2, and phosphorylation of PKA substrates in Neuro2a neuronal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
BRP (5 mg/kg; i.p.; daily; 14 days) reverses obesity and improves glucose homeostasis in diet-induced obese male C57BL/6J mice by reducing food intake and fat mass[1].
BRP (2 mg/kg; i.m.; single dose) suppresses feeding behavior in male Yucatan miniature pigs without inducing anxiety-like behavior[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (8-week-old male; 8-week-old female)[1]
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Dosage:0.5-20 mg/kg (i.p., single dose); 10 mg/kg (i.n., single dose); 0.5 mg/kg (i.c.v., single dose)
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Administration:i.p. (single dose); i.n. (single dose); i.c.v. (single dose, infused into lateral ventricle over ~30s)
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Result:Potently and immediately suppressed food intake for up to 3 hours in lean male mice at 5 mg/kg i.p..
Almost completely suppressed food intake over 3 hours in lean male mice at 20 mg/kg i.p..
Did not lower food intake in lean male mice at 0.5 mg/kg i.p..
Suppressed food intake over 3 hours in lean female mice at 5 mg/kg i.p..
Suppressed food intake over 3 hours in lean male mice at 10 mg/kg i.p..
Suppressed food intake over 3 hours in lean male mice at 10 mg/kg i.n..
Suppressed food intake over 3 hours in lean male mice at 0.5 mg/kg i.c.v..
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Animal Model:C57BL/6J (6-week diet-induced obese male)[1]
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Dosage:1-5 mg/kg
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Administration:i.p. (daily; 14 days)
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Result:Reduced accumulated food intake and body weight.
Improved glucose tolerance and insulin tolerance.
Reduced inguinal white adipose tissue mass, reduced brown adipose tissue mass, reduced liver mass, reduced adipocyte size in inguinal white adipose tissue, reduced ectopic hepatic lipid accumulation, and reduced fat mass without affecting lean mass.
化学情報
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性状 Solid
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分子量 1540.88
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分子式 C68H117N25O14S
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Color White to off-white
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別名
BRINP2-related peptide
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配列
Thr-His-Arg-Ile-Leu-Arg-Arg-Leu-Phe-Asn-Leu-Cys-NH2
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シーケンスの短縮
THRILRRLFNLC-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
H2O : ≥ 100 mg/mL (64.90 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
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- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.6490 mL | 3.2449 mL | 6.4898 mL | 16.2245 mL |
| 5 mM | 0.1298 mL | 0.6490 mL | 1.2980 mL | 3.2449 mL | |
| 10 mM | 0.0649 mL | 0.3245 mL | 0.6490 mL | 1.6224 mL | |
| 15 mM | 0.0433 mL | 0.2163 mL | 0.4327 mL | 1.0816 mL | |
| 20 mM | 0.0324 mL | 0.1622 mL | 0.3245 mL | 0.8112 mL | |
| 25 mM | 0.0260 mL | 0.1298 mL | 0.2596 mL | 0.6490 mL | |
| 30 mM | 0.0216 mL | 0.1082 mL | 0.2163 mL | 0.5408 mL | |
| 40 mM | 0.0162 mL | 0.0811 mL | 0.1622 mL | 0.4056 mL | |
| 50 mM | 0.0130 mL | 0.0649 mL | 0.1298 mL | 0.3245 mL | |
| 60 mM | 0.0108 mL | 0.0541 mL | 0.1082 mL | 0.2704 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
BRP 関連分類
HY-P10927 関連分類
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