Bulaquine
Bulaquine (CDRI 80/53) is a potent antimalarial agent which is an analogue of Primaquine (HY-12651A). Bulaquine affects multiple metabolism pathways and shows inhibition effect on Plasmodium cynomolgi infection. Bulaquine can be used for the research of malaria.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 79781-00-3
- 分子式: C21H27N3O3
- 分子量:369.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
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Plasmodium |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | IC50 |
10 μM
Compound: 2
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Antiplasmodial activity against liver stage Plasmodium berghei infected in Huh7 cells assessed as inhibition of parasite infection incubated for 1 hr prior to infection measured at 24 hrs by luciferase reporter gene assay
Antiplasmodial activity against liver stage Plasmodium berghei infected in Huh7 cells assessed as inhibition of parasite infection incubated for 1 hr prior to infection measured at 24 hrs by luciferase reporter gene assay
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[PMID: 26968650] |
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:25-30 g male Swiss albino mice[1]
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Dosage:40 mg/kg
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Administration:Oral gavage; 40 mg/kg once
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Result:Affected oxidative stress and fatty acid synthesis pathway, apoptosis, cell cycle, inflammatory response, glycogen metabolism, Kreb’s cycle, electron transport chain, fatty acid β-oxidation, MAPK signalling, signalling of hepatocyte growth factor receptor, matrix metalloproteinases, steroid biosynthesis, TGF-β signalling, translation factors, Wnt signalling, regulation of actin cytoskeleton, ribosomal proteins, RNA transcription reactome, proteasome degradation and nuclear receptors in lipid metabolism according to GO results.
化学情報
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CAS 番号 79781-00-3
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分子量 369.46
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分子式 C21H27N3O3
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SMILES
C/C(NCCCC(NC1=CC(OC)=CC2=C1N=CC=C2)C)=C3C(OCC/3)=O
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別名
CDRI 80/53; Elubaquine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
純度とドキュメンテーション
参考文献
[1]. Noel S, et al. Identification of differentially expressed genes after acute exposure to bulaquine (CDRI 80/53) in mice liver. Basic Clin Pharmacol Toxicol. 2008 Dec;103(6):522-9. [Content Brief]
[2]. Dutta GP, et al. Radical curative activity of a new 8-aminoquinoline derivative (CDRI 80/53) against Plasmodium cynomolgi B in monkeys. Am J Trop Med Hyg. 1989 Dec;41(6):635-7. [Content Brief]
[3]. Wells TN, et al. Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination. Trends Parasitol. 2010 Mar;26(3):145-51.Wells TN, et al. Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination. Trends Parasitol. 2010 Mar;26(3):145-51. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Bulaquine 関連分類
HY-106866 関連分類
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