BV6 TFA
Based on 22 publication(s) in Google Scholar
BV6 TFA is an antagonist of cIAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family. BV6 TFA shows an IC50 of 7.2 μM in MTS assays in HCC193 cells. BV6 TFA can be used in the research of endometrial cancer and endometriosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.61%
- 分子式: C70H96N10O8·xC2HF3O2
- 分子量:1205.57 (free base)
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 BV6 TFA
More- Cell Mol Immunol. 2023 Oct;20(10):1203-1215. [Abstract]
- Nat Commun. 2018 Mar 19;9(1):1136. [Abstract]
- Cell Death Differ. 2022 Oct;29(10):2034-2045. [Abstract]
- Cell Death Dis. 2025 Oct 6;16(1):683. [Abstract]
- Cell Death Dis. 2023 Oct 12;14(10):673. [Abstract]
- J Orthop Translat. 2024 Jun 7:47:15-28. [Abstract]
- J Med Chem. 2025 Oct 23;68(20):21766-21785. [Abstract]
- J Taiwan Inst Chem Eng. June 2022, 104394.
- Biomater Adv. 2025 May:170:214185. [Abstract]
- Neurobiol Dis. 2019 Jul:127:570-581. [Abstract]
- Mol Neurobiol. 2021 May;58(5):2435-2446. [Abstract]
- Chem Biol Interact. 2025 Sep 4:111724. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2019 Oct 1;1865(10):2618-2632. [Abstract]
- iScience. 2022 Sep 19;25(10):105166. [Abstract]
- J Cell Sci. 2019 May 20;132(10):jcs227777. [Abstract]
- Exp Cell Res. 2021 Jul 15;404(2):112638. [Abstract]
- Research Square Preprint. 2023 Aug 17.
- University of Portland. 2022.
- Research Square Preprint. 2021 Jul.
- Research Square Preprint. 2020 May.
- Aging (Albany NY). 2018 Oct 18;10(10):2783-2799. [Abstract]
- bioRxiv. May 2, 2018.
Customer Validation & Images
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生物活性
BV6 TFA (250 nM-30 μM, 24 h) induces apoptosis in HCC193 and H460 lung cancer cell lines in a concentration- and time-dependent manner. BV6 TFA (250 nM-30 μM, 24 h) can also enhance the sensitivity of HCC193 and H460 cell lines to radiation[1].
BV6 TFA (1μM 24 h; 5 μM, 48 h) significantly sensitizes the cell to radiation (HCC193-DER=1.38, at 1μM BV6; H460-DER=1.42, at 5μM BV6)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCC193 cells, H460 cells
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Concentration:250 nM, 500 nM, 1 μM, 3 μM, 5 μM, 10 μM, 20 μM, 30 μM
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Incubation Time:24 hours
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Result:Decreased cell survival percentage for HCC193 with an IC50 of 7.2μM.
Decreased the cell viability of H460 cells by about 60% at 30 μM.
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Cell Line:HCC193 cells, H460 cells
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Concentration:0.25 μM, 0.5 μM, 1 μM, 5 μM
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Incubation Time:1, 14, 24 hours
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Result:Reduced the expression of cIAP1 within one hour and gradually decreased XIAP with increased incubation time for both cell lines.
Reduced the expression of cIAP1 with 0.25μM and gradually decreased XIAP with increasing concentration for both cell lines.
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Cell Line:HCC193 cells, H460 cells
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Concentration:1 μM, 5 μM
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Incubation Time:12 hours
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Result:Induced enhancement of the secretion of TNFα in HCC193 cells.
Did not enhance the secretion of TNFα in H460 cells.
BV6 TFA (10 mg/kg, twice weekly for 4 weeks, i.p.) reduces the total number of lesions and the percentage of Ki67-positive cells compared to the control[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female endometriosis mice modeling by Estradiol valerate (HY-B0672) at the dosage 0.5 µg/mouse/week s.c injected (6 weeks of age, BALB/c).
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Dosage:10 mg/kg
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Administration:a single i.p. injection,twice weekly for 4 weeks
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Result:Attenuated the intensity of IAPs expression.
化学情報
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性状 Solid
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分子量 1205.57 (free base)
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分子式 C70H96N10O8·xC2HF3O2
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SMILES
O=C(NCCCCCCNC([C@@H](NC([C@H](CCC1)N1C([C@H](C2CCCCC2)NC([C@H](C)NC)=O)=O)=O)C(C3=CC=CC=C3)C4=CC=CC=C4)=O)[C@@H](NC([C@H](CCC5)N5C([C@H](C6CCCCC6)NC([C@H](C)NC)=O)=O)=O)C(C7=CC=CC=C7)C8=CC=CC=C8.OC(C(F)(F)F)=O.[x]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (22)
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Journal Impact Factor
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Most Recent
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Cell Mol Immunol
2023 Oct;20(10):1203-1215. PMID: 37591930 -
Nat Commun
Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus. [Abstract]2018 Mar 19;9(1):1136. PMID: 29555915
BV6 TFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2018 Mar 19;9(1):1136. [Abstract]
Western Blot analysis of p52, p100, NIK, c-IAP2, Peli1, and HSP60 in total lysis of control and Peli1-knockdown M12 cells that pretreated with DMSO or smac mimetic BV6 for 4 h, and then stimulated with anti-CD40 (αCD40) at the indicated time points.
BV6 TFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2018 Mar 19;9(1):1136. [Abstract]
Western Blot analysis of p52, p100, NIK, c-IAP2, Peli1, and HSP60 in total lysis of control and Peli1-knockdown M12 cells that pretreated with DMSO or smac mimetic BV6 for 4 h, and then stimulated with BAFF at the indicated time points.
BV6 TFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2018 Mar 19;9(1):1136. [Abstract]
Analysis of Lys48 ubiquitination of NIK in control and Peli1-knockdown M12 cells that pretreated with DMSO or smac mimetic BV6 for 4 h, then left unstimulated or stimulated with anti-CD40 (αCD40) for 4 h in the presence of MG132.
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Cell Death Differ
Ubiquitin-binding domain in ABIN1 is critical for regulating cell death and inflammation during development. [Abstract]2022 Oct;29(10):2034-2045. PMID: 35430614 -
Cell Death Dis
Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions. [Abstract]2025 Oct 6;16(1):683. PMID: 41053093 -
Cell Death Dis
Polarity protein AF6 functions as a modulator of necroptosis by regulating ubiquitination of RIPK1 in liver diseases. [Abstract]2023 Oct 12;14(10):673. PMID: 37828052 -
J Orthop Translat
2024 Jun 7:47:15-28. PMID: 38957269 -
J Med Chem
Discovery of a 1 H-Pyrazol-3-Amine Derivative as a Novel, Selective, and Orally Available RIPK1 Inhibitor for the Treatment of Inflammatory Disease. [Abstract]2025 Oct 23;68(20):21766-21785. PMID: 41077763 -
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Biomater Adv
Etoposide-loaded lipopolymer nanoparticles promote Smac minetic activity against inhibitor of apoptosis protein for glioblastoma treatment. [Abstract]2025 May:170:214185. PMID: 39879864 -
Neurobiol Dis
2019 Jul:127:570-581. PMID: 30981830 -
Mol Neurobiol
Myeloid TBK1 Deficiency Induces Motor Deficits and Axon Degeneration Through Inflammatory Cell Infiltration. [Abstract]2021 May;58(5):2435-2446. PMID: 33439438 -
Chem Biol Interact
Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury. [Abstract]2025 Sep 4:111724. PMID: 40914538 -
Biochim Biophys Acta Mol Basis Dis
Directed elimination of senescent cells attenuates development of osteoarthritis by inhibition of c-IAP and XIAP. [Abstract]2019 Oct 1;1865(10):2618-2632. PMID: 31251987 -
iScience
The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes. [Abstract]2022 Sep 19;25(10):105166. PMID: 36204273 -
J Cell Sci
FKBP12 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation. [Abstract]2019 May 20;132(10):jcs227777. PMID: 31028177 -
Exp Cell Res
Indole-3-carbinol ameliorates necroptosis and inflammation of intestinal epithelial cells in mice with ulcerative colitis by activating aryl hydrocarbon receptor. [Abstract]2021 Jul 15;404(2):112638. PMID: 34015312 -
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Aging (Albany NY)
Ubiquitin-specific protease 4 promotes metastasis of hepatocellular carcinoma by increasing TGF-β signaling-induced epithelial-mesenchymal transition. [Abstract]2018 Oct 18;10(10):2783-2799. PMID: 30335615 -
純度とドキュメンテーション
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データシート (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Li W, et al. BV6, an IAP antagonist, activates apoptosis and enhances radiosensitization of non-small cell lung carcinoma in vitro. J Thorac Oncol. 2011 Nov;6(11):1801-9. [Content Brief]
[2]. Uegaki T, et al. Inhibitor of apoptosis proteins (IAPs) may be effective therapeutic targets for treating endometriosis. Hum Reprod. 2015 Jan;30(1):149-58. [Content Brief]
Calculators
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BV6 TFA 関連分類
HY-16701A 関連分類
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