カマレキシン
Based on 3 publication(s) in Google Scholar
Camalexin is a phytoalexin isolated from Camelina sativa (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production.
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- 純度: 99.70%
- CAS 番号: 135531-86-1
- 分子式: C11H8N2S
- 分子量:200.26
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Camalexin
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生物活性
Camalexin shows antiproliferative activity against a human breast cancer cell line[2].
For the oomycetes Phytophthora and Pythium Nep1-like proteins (necrosis and ethylene-inducing peptide 1-like proteins) are the initial triggers of Camalexin synthesis and formation of reactive oxygen species (ROS). ROS appear to be of general relevance for Camalexin formation. Chemical induction of ROS, such as by application of acifluorfen, coincided with Camalexin synthesis. In a screen for enhanced susceptibility to Alternaria brassicicola the esa1 mutant is identified, which shows delayed Camalexin induction. Particularly in response to ROS inducing agents reduced Camalexin levels are synthesized. This crucial role for ESA1 is confirmed by the inability of esa1 mutants to synthesize Camalexin in response to Leptosphaeria maculans. An additional mutant that exhibits greatly reduced Camalexin accumulation is ups1, which is isolated on the basis of diminished expression of a tryptophan biosynthetic enzyme[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 135531-86-1
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性状 Solid
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分子量 200.26
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分子式 C11H8N2S
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Color White to yellow
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SMILES
C12=C(C=CC=C2)NC=C1C3=NC=CS3
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別名
Camalexin
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Structure Classification
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
2026 Mar;13(16):e13310. PMID: 41589654 -
Sci China Life Sci
Promotion of Arabidopsis immune responses by a rhizosphere fungus via supply of pipecolic acid to plants and selective augment of phytoalexins. [Abstract]2023 May;66(5):1119-1133. PMID: 36449213 -
Cell Physiol Biochem
2017;41(2):731-741. PMID: 28222420
溶剤 & 溶解度
DMSO : 175 mg/mL (873.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.9935 mL | 24.9675 mL | 49.9351 mL | 124.8377 mL |
| 5 mM | 0.9987 mL | 4.9935 mL | 9.9870 mL | 24.9675 mL | |
| 10 mM | 0.4994 mL | 2.4968 mL | 4.9935 mL | 12.4838 mL | |
| 15 mM | 0.3329 mL | 1.6645 mL | 3.3290 mL | 8.3225 mL | |
| 20 mM | 0.2497 mL | 1.2484 mL | 2.4968 mL | 6.2419 mL | |
| 25 mM | 0.1997 mL | 0.9987 mL | 1.9974 mL | 4.9935 mL | |
| 30 mM | 0.1665 mL | 0.8323 mL | 1.6645 mL | 4.1613 mL | |
| 40 mM | 0.1248 mL | 0.6242 mL | 1.2484 mL | 3.1209 mL | |
| 50 mM | 0.0999 mL | 0.4994 mL | 0.9987 mL | 2.4968 mL | |
| 60 mM | 0.0832 mL | 0.4161 mL | 0.8323 mL | 2.0806 mL | |
| 80 mM | 0.0624 mL | 0.3121 mL | 0.6242 mL | 1.5605 mL | |
| 100 mM | 0.0499 mL | 0.2497 mL | 0.4994 mL | 1.2484 mL |
Camalexin 関連分類
HY-119502 関連分類
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