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Cinrebafusp alfa

(別名: PRS 343)
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Based on 1 Customer Validation

Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度: 98.53%
  • CAS 番号: 2218515-90-1
  • 分子量:187.87 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Cinrebafusp alfa
  • Experimental Validation Results for Cinrebafusp alfa
  • Experimental Validation Results for Cinrebafusp alfa
  • Cinrebafusp alfa Chemical Structure
    Cinrebafusp alfa 構造式
CAS 番号: 2218515-90-1
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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100 mg

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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized Cinrebafusp alfa can bind Human 4-1BB/CD137 Protein (ECD, His Tag). The EC50 for this effect is 1.33 ng/mL.

  • 1/16

    Immobilized Cinrebafusp alfa can bind Human Her2/ERBB2 Protein (ECD, His Tag). The EC50 for this effect is 1.66 ng/mL.

  • Cinrebafusp alfa Chemical Structure
    1/16
  • Cinrebafusp alfa
  • Immobilized Cinrebafusp alfa can bind Human 4-1BB/CD137 Protein (ECD, His Tag). The EC50 for this effect is 1.33 ng/mL.
  • Immobilized Cinrebafusp alfa can bind Human Her2/ERBB2 Protein (ECD, His Tag). The EC50 for this effect is 1.66 ng/mL.